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A Comparison of the Thrombogenic Activity of Prothrombin Complex Concentrates Using Stasis and Non-stasis Models

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Recent Developments in Toxicology: Trends, Methods and Problems

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 14))

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Abstract

Patients treated with prothrombin complex concentrates (PCC) have frequently been found to develop thrombotic events (Kaspar 1975; Cederbaum 1976). Therefore, PCC must be regarded as potentially thrombogenic substances (Elödi 1977). In order to reduce the risk of thromboembolic complications the addition of heparin was recommended (Ménaché and Roberts 1975).

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References

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Author information

Authors and Affiliations

  1. Institute of Pharmacology and Toxicology, Medical Academy, Erfurt, Germany

    M. Richter, H.-P. Klöcking & R. Wulkow

  2. District Institute of Blood Transfusion, Suhl, Germany

    G. Dornheim

  3. Institute of Microbiology and Experimental Therapy, Jena, Germany

    J. Güttner

Authors
  1. M. Richter
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  2. H.-P. Klöcking
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  3. G. Dornheim
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  4. J. Güttner
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  5. R. Wulkow
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Editor information

Editors and Affiliations

  1. Department of Pharmacology and Therapeutics, Trinity College, University of Dublin, Dublin 2, Ireland

    Philip L. Chambers  & Claire M. Chambers  & 

  2. Institut für Pharmakologie und Toxikologie, Universität Leipzig, Universitätsbereich Medizin, Härtelstraße 16-18, O-7010, Leipzig, Germany

    Wolf Diether Wiezorek

  3. Veterinärmedizinische Fakultät, Institut für Pharmakologie, Pharmazie und Toxikologie, Universität Leipzig, Zwickauer Straße 55, O-7010, Leipzig, Germany

    Siegfried Golbs

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© 1991 Springer-Verlag Berlin Heidelberg

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Richter, M., Klöcking, HP., Dornheim, G., Güttner, J., Wulkow, R. (1991). A Comparison of the Thrombogenic Activity of Prothrombin Complex Concentrates Using Stasis and Non-stasis Models. In: Chambers, P.L., Chambers, C.M., Wiezorek, W.D., Golbs, S. (eds) Recent Developments in Toxicology: Trends, Methods and Problems. Archives of Toxicology, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74936-0_34

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  • DOI: https://doi.org/10.1007/978-3-642-74936-0_34

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-51422-0

  • Online ISBN: 978-3-642-74936-0

  • eBook Packages: Springer Book Archive

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