Effects of Snake Venoms on Tissue-Type Plasminogen Activator Release

  • H.-P. Klöcking
  • A. Hoffmann
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 14)


Proteins from snake venoms may act on all parts of the haemostatic system in mammal organisms, i.e. also on the fibrinolytic system (Stocker and Meier 1989).


Serine Protease Snake Venom Fibrinolytic System Perfusion Solution Mammal Organism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Furie BC, Furie B (1976) Coagulant protein Russell’s viper venom. Meth Enzymol 45:191–205PubMedCrossRefGoogle Scholar
  2. Kirby EP, Niewiarowski S, Stocker K, Kettner Ch, Shaw E, Brudzynski M (1979) Thrombocytin, a serine protease from Bothrops atrox venom. 1. Purification and characterization of the enzyme. Biochemistry 18:3564–3570PubMedCrossRefGoogle Scholar
  3. Klöcking HP, Bock G, Drawert J, Hinsenbrock KP, Kaiser B, Sedlarik U (1976) Über die Freisetzung von Plasminogenaktivatoren. Folia Haematol 103:404–424Google Scholar
  4. Klöcking HP, Hoffmann A, Markwardt F (1987) Release of plasminogen activator by batroxobin. Haemostasis 17:235–237PubMedGoogle Scholar
  5. Klöcking HP, Hoffmann A, Markwardt F (1988) Influence of hirudin on the thrombininduced release of tissue plasminogen activator from isolated perfused pig ear. Folia Haematol 115: 110–112Google Scholar
  6. Klöcking HP, Markwardt F, Güttner J (1989) On the mechanism of batroxobin-induced fibrinolysis. Pharmazie 44:504–505PubMedGoogle Scholar
  7. Kornalik F, Blombeack B (1975) Prothrombin activation induced by ecarin – a prothrombin converting enzyme from Echis carinatus venom. Thromb Res 6:53–63CrossRefGoogle Scholar
  8. Morita T, Iwanaga S (1981) Prothrombin activator from Echis carinatus venom. Meth Enzymol 80:303–311CrossRefGoogle Scholar
  9. Shimizu A, Jimenez EC, Takagi J, Inada Y, Saito Y (1987) Venom from southern copperhead snake (Agkistrodon controtrix contortrix). I. Characterization of a protease that preferentially releases fibrinopeptide B. Toxicon 25: 751–757PubMedCrossRefGoogle Scholar
  10. Stocker K, Meier J (1989) Schlangengiftproteine in der Hamostaseologie: Neuere Erkenntnisse. Folia Haematol 116:935–953Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • H.-P. Klöcking
    • 1
  • A. Hoffmann
    • 1
  1. 1.Institute of Pharmacology and ToxicologyMedical Academy ErfurtErfurtGDR

Personalised recommendations