Abstract
A number of studies have been carried out on the toxic effect of aluminium on bone mineralization and its relation to calcium and parathroid-hormone metabolism. Exposure to aluminium by the means of either diasylate or ingestion of aluminium hydroxide or both leads to its deposition in tissues, particularly in bone. This deposition blocks incorporation of calcium into osteoids, leading to the osteomalacia characteristic of aluminium-induced bone disease (Drucke 1980; Alfrey 1980; Cournot-Witmer et al 1981; Walker et al 1982; Mayor et al 1980; Cann et al 1979; Cannata et al 1983; Boyce et al 1982). Therefore, the effects of aluminium hydroxide loading on bone of mice were examined. Besides aluminium, the calcium level of the same bone samples were determined and aluminium/calcium ratios were evaluated in this study. The aluminium and calcium measurements have been performed by graphite furnace and flame atomic absorption spectrometry respectively.
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© 1991 Springer-Verlag Berlin Heidelberg
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Sahin, G., Isimer, A., Temizer, A., Sayal, A., Sunal, R., Duru, S. (1991). The Effect of Aluminium Loading on Bones of Mice. In: Chambers, P.L., Chambers, C.M., Wiezorek, W.D., Golbs, S. (eds) Recent Developments in Toxicology: Trends, Methods and Problems. Archives of Toxicology, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74936-0_18
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DOI: https://doi.org/10.1007/978-3-642-74936-0_18
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