Nifedipine Retard as Monotherapy for Essential Hypertension: A Randomized Controlled Cross-over Study
Over the past couple of decades diuretics, methyldopa, and β-blockers have been the common drugs used as first-line regimen for treating hypertension [1–3]. Some large-scale long-term studies, however, have unmasked certain side effects of the diuretics and β-blockers, and they were seen not to be well tolerated in certain patients [4–9]. These findings have stimulated interest in the search for alternative regimens. Calcium antagonists have been found to be safe and effective in treating hypertensive crisis as well as resistant hypertension, although experience is still limited regarding its application as a firststep monotherapy regimen in hypertension [10–11]. With the availability of a long-acting preparation of nifedipine that is more convenient for users, the application of nifedipine as a first-line drug for treating mild to moderate hypertension may prove desirable and appealing [12–13].
KeywordsPlacebo Cholesterol Urea Creatinine Titration
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