Study on the Clinical Effectiveness of Adalat L Tablet for Angina Pectoris: A Double-blind Study with Adalat as a Reference Drug
Nifedipine is a potent Ca2+antagonist and is effective not only for vasospastic angina but also for stable-effort angina . Nifedipine was initially supplied as a liquid-filled capsule formulation with rapid- but short-acting characteristics. The nifedipine capsule is generally administered every 8 h, however the administration of nifedipine t. i. d. cannot control episodes of the variant form of angina pectoris which occur early in the morning . Adalat L (Bayer) was therefore developed for the purpose of producing a long-acting effect. It has been reported that 12 h after oral administration of 20 mg Adalat L, its plasma concentration was still higher than the minimal effective level.
KeywordsPlacebo Depression Ischemia Anemia Cardiol
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