Study on the Clinical Effectiveness of Adalat L Tablet for Angina Pectoris: A Double-blind Study with Adalat as a Reference Drug

  • Y. Nakamura
  • H. Miyashita
  • O. Iimura
  • K. Ueda
  • T. Sugimoto
  • Y. Toyama
Conference paper


Nifedipine is a potent Ca2+antagonist and is effective not only for vasospastic angina but also for stable-effort angina [1]. Nifedipine was initially supplied as a liquid-filled capsule formulation with rapid- but short-acting characteristics. The nifedipine capsule is generally administered every 8 h, however the administration of nifedipine t. i. d. cannot control episodes of the variant form of angina pectoris which occur early in the morning [2]. Adalat L (Bayer) was therefore developed for the purpose of producing a long-acting effect. It has been reported that 12 h after oral administration of 20 mg Adalat L, its plasma concentration was still higher than the minimal effective level[3].


Subjective Improvement Isosorbide Dinitrate Anginal Attack Placebo Period Variant Angina 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • Y. Nakamura
    • 1
  • H. Miyashita
    • 2
  • O. Iimura
    • 3
  • K. Ueda
    • 4
  • T. Sugimoto
    • 5
  • Y. Toyama
    • 6
  1. 1.Department of MedicineKeio University School of MedicineJapan
  2. 2.Second Department of MedicineTeikyo University School of MedicineJapan
  3. 3.Second Department of MedicineSapporo Medical CollegeJapan
  4. 4.Department of Internal MedicineTokyo Metropolitan Geriatric HospitalJapan
  5. 5.Second Department of MedicineToyama Medical and Pharmaceutical University Faculty of MedicineJapan
  6. 6.Department of CardiologyThe Center for Adult DiseasesOsakaJapan

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