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Platelet-Derived Growth Factor: Formation and Biological Activities

  • Chapter
Growth Factors, Differentiation Factors, and Cytokines

Abstract

Platelet-derived growth factor (PDGF) consists of several closely related glycoproteins of approximately 30 kDa (Deuel et al. 1981; Raines and Ross 1982) made up of three combinations of two disulfide-bonded chains, denoted the A and B chains. PDGF binds to two distinct but closely related PDGF receptors, termed a- and β-receptors (Yarden et al. 1986; Gronwald et al. 1988; Matsui et al. 1989). The predominant biological role of PDGF is to stimulate proliferation of mesenchymal cells (reviewed by Ross et al. 1986), but other biological effects have been reported. PDGF is a potent vasoconstrictor (Berk et al. 1986); it exerts strong chemotactic activities towards mesenchymal and several hematopoetic cells (Grotendorst et al. 1981; Williams et al. 1983); and it promotes polymorphonuclear leukocyte and monocyte activation (Tzeng et al. 1985). PDGF-like molecules are synthesized by cells as diverse as megakaryocytes, macrophages, mesangial cells, arterial smooth muscle cells, type I astrocytes, endothelial cells, cytotrophoblast cells of the placenta, blastocyst cells, and numerous cell lines and transformed cells (references in Table 1). The widespread occurrence and tightly controlled expression of PDGF and its receptors in vivo have been taken as evidence that PDGF-like molecules play a role in many fundamental biological processes such as embryogenesis, the development of the central nervous system, and wound healing.

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Authors
  1. A. J. R. Habenicht
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  2. P. Salbach
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  3. C. Blattner
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  4. U. Janßen-Timmen
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Editors and Affiliations

  1. Department of Internal Medicine Division of Endocrinology and Metabolism, University of Heidelberg, Bergheimer Straße 58, D-6900, Heidelberg, Germany

    Andreas Habenicht

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Habenicht, A.J.R., Salbach, P., Blattner, C., Janßen-Timmen, U. (1990). Platelet-Derived Growth Factor: Formation and Biological Activities. In: Habenicht, A. (eds) Growth Factors, Differentiation Factors, and Cytokines. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74856-1_3

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  • DOI: https://doi.org/10.1007/978-3-642-74856-1_3

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