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Colony Stimulating Factor-1

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Growth Factors, Differentiation Factors, and Cytokines

Abstract

The macrophage colony stimulating factor, colony stimulating factor-1 (CSF-1), selectively stimulates the survival, proliferation, and differentiation of mononuclear phagocytes from the determined, undifferentiated progenitor cell, through the various intermediate stages of differentiation (monoblast - promonocyte - monocyte), to the mature macrophage (Stanley et al. 1983). In addition, the endocrine-regulated uterine synthesis of large amounts of CSF-1 during pregnancy (Bartocci et al. 1986; Pollard et al. 1987) indicates that the growth factor also has a role in placental development via its action on CSF-1 receptor-bearing decidual and trophoblastic cells. CSF-1 is produced by fibroblast-like cells in the bone marrow and in the peritoneal cavity (Tushinski et al. 1982), stimulated normal human monocytes (Horiguchi et al. 1988), endothelial cells (Sieff et al. 1988; P. Roth, A. Bartocci, E. R. Stanley, unpublished observation), and, during pregnancy, by the cell of the mouse uterine epithelium (Bartocci et al. 1986; Pollard et al. 1987). Biologically active concentrations of CSF-1 are detected in serum (1 nM) and in various mouse tissues (Bartocci et al. 1986).

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Authors
  1. M. Baccarini
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  2. E. R. Stanley
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Editors and Affiliations

  1. Department of Internal Medicine Division of Endocrinology and Metabolism, University of Heidelberg, Bergheimer Straße 58, D-6900, Heidelberg, Germany

    Andreas Habenicht

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Baccarini, M., Stanley, E.R. (1990). Colony Stimulating Factor-1. In: Habenicht, A. (eds) Growth Factors, Differentiation Factors, and Cytokines. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74856-1_14

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  • DOI: https://doi.org/10.1007/978-3-642-74856-1_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74858-5

  • Online ISBN: 978-3-642-74856-1

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