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Prognosis of Endometrial Carcinoma

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Endometrial Carcinoma

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Abstract

In the FIGO Annual Report (1985), 5-year survival was 67.7% in 13 581 cases of endo-metrial carcinoma (Table 5.1). The reported figures of survival have been consistent, ranging from 66% to 77% (Frick et al. 1973; Morrow et al. 1973; Berman et al. 1980; Connelly et al. 1982; Kauppila et al. 1982). Li (1988), reviewing 418 cases of endometrial carcinoma, found 5-year survival to be 77.6% for stage I, 59.6% for stage II, and 61.9% for stages I–IV respectively. The low mortality is probably related to the fact that over 80% of the cases were confined to the uterus (FIGO stages I, II) at initial diagnosis and approximately 75% of cases could be treated by surgery and/or radiotherapy.

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References

  • Aalders JG, Abeier V, Kolstad P et al. (1980) Post-operative external irradiation and prognostic parameters in stage I endometrial carcinoma: clinical and histopathologic study of 540 patients. Obstet Gynecol 56:419–427

    PubMed  CAS  Google Scholar 

  • Aalders JG, Abeler V, Kolstad P (1984a) Recurrent adenocarcinoma of the endometrium: a clinical and histopathological study of 379 patients. Gynecol Oncol 17:85–103

    Article  PubMed  CAS  Google Scholar 

  • Aalders JG, Abeler V, Kolstad P (1984b) Stage IV endometrial carcinoma: a clinical and histopathological study of 83 patients. Gynecol Oncol 17:75–84

    Article  PubMed  CAS  Google Scholar 

  • Alberhasky RC, Connelly PJ, Christopherson WM (1982) Carcinoma of the endometrium. IV. Mixed adenosquamous carcinoma. Am J Clin Pathol 77:655–664

    PubMed  CAS  Google Scholar 

  • Austin JH, MacMahon B (1969) Indicators of prognosis in carcinoma of the corpus uteri. Surg Gynecol Obstet 128:1247–1252

    PubMed  CAS  Google Scholar 

  • Baram A, Figer A, Inbar M et al. (1985) Endometrial carcinoma stage I - comparison of two different treatment regimes — evaluation of risk factors and its influence on prognosis; suggested step by step treatment protocol. Gynecol Oncol 22:294–301

    Article  PubMed  CAS  Google Scholar 

  • Berman ML, Barlow SC, Lagasse LD et al. (1980) Prognosis and treatment of endometrial cancer. Am J Obstet Gynecol 136:679–688

    PubMed  CAS  Google Scholar 

  • Boronow RC (1977) Endometrial cancer: staging, pre-treatment evaluation and factors in outcome. In: Gray LA Sr (ed) Endometrial carcinoma and its treatment: the role of irradiation, extent of surgery, and approach to chemotherapy, vol III. Thomas, Springfield, p 38–57

    Google Scholar 

  • Boronow RC, Morrow CP, Creasman WT et al. (1984) Surgical staging of endometrial cancer: clinical-pathologic findings of a prospective study. Obstet Gynecol 63:825–838

    PubMed  CAS  Google Scholar 

  • Boutselis JG (1978) Endometrial carcinoma: prognostic factors and treatment. Surg Clin North Am 58:109–119

    PubMed  CAS  Google Scholar 

  • Bruckman JE, Goodman RL, Murthy A, Marck A (1978) Combined irradiation and surgery in the treatment of stage II carcinoma of the endometrium. Cancer 42:1146–1151

    Article  PubMed  CAS  Google Scholar 

  • Chen SS (1985) Extrauterine spread in endometrial carcinoma clinically confined to the uterus. Gynecol Oncol 21:23–31

    Article  PubMed  Google Scholar 

  • Cheon H (1969) Prognosis of endometrial carcinoma. Obstet Gynecol 34:680–684

    PubMed  CAS  Google Scholar 

  • Climie ARW, Rachmaninoff N (1965) A ten year experience with endometrial carcinoma. Surg Gynecol Obstet 120:73–78

    PubMed  CAS  Google Scholar 

  • Connelly PJ, Alberhasky RC, Christopherson WM (1982) Carcinoma of the endometrium III. Analysis of 865 cases of adenocarcinoma and adeno-canthoma. Obstet Gynecol 59:569

    PubMed  CAS  Google Scholar 

  • Corscaden JA, Tovell HMM (1954) The management of carcinoma of the corpus. Am J Obstet Gynecol 68:737–760

    PubMed  CAS  Google Scholar 

  • Creasman WT, Rutledge FN (1971) The prognostic value of peritoneal cytology in gynecologic malignant disease. Am J Obstet Gynecol 110:773–781

    PubMed  CAS  Google Scholar 

  • Creasman WT, Borrow RC, Morrow CP et al. (1976) Adenocarcinoma of the endometrium: its metastatic lymph node potential. A preliminary report. Gynecol Oncol 4:239–243

    Article  PubMed  CAS  Google Scholar 

  • Creasman WT, McCarty KS, Sr, Barton TK et al. (1980) Clinical correlates of estrogen and progesterone-binding proteins in human endometrial adenocarcinoma. Obstet Gynecol 55:363–370

    PubMed  CAS  Google Scholar 

  • Creasman WT, DiSaia PJ, Blessing J et al. (1981) Prognostic significance of peritoneal cytology in patients with endometrial cancer and preliminary data concerning therapy with intraperitoneal radiopharmaceuticals. Am J Obstet Gynecol 141:921–929

    PubMed  CAS  Google Scholar 

  • DeMuelenaere GF (1975) Prognostic factors in endometrial carcinoma. S Afr Med J 49:1695–1698

    CAS  Google Scholar 

  • DiSaia PJ, Creasman WT (1981) Adenocarcinoma of the uterus. In: DiSaia PJ, Creasman WT (eds) Clinical gynecologic oncology. Mosby, St Louis, p 128–151

    Google Scholar 

  • DeSombre ER, Greene GL, King WT, Jensen EV (1984) Estrogen receptors, antibodies and hormone dependent cancer. In: Gurpide E, Calandra, Levy C, Soto RJ (eds) Hormones and Cancer. Liss, New York, Vol 142 1–21

    Google Scholar 

  • Ehrlich CE, Young PCM, Cleary RE (1981) Cytoplasmic progesterone and estradiol receptors in normal, hyperplastic, and carcinomatous endometria: therapeutic implications. Am J Obstet Gynecol 141:539–546

    PubMed  CAS  Google Scholar 

  • Emge LA (1962) The elusive adenomyosis of the uterus. Am J Obstet Gynecol 83:1541–1563

    PubMed  CAS  Google Scholar 

  • FIGO (1985) Annual report 19:126

    Google Scholar 

  • Friberg LG, Kullander S, Persijn JP, Korsten CB (1978) On receptors for estrogen (E2) and androgens (DHT) in human endometrial carcinoma and ovarian tumours. Acat Obstet Gynecol Scand 57:265–271

    Article  Google Scholar 

  • Frick HC, Munnell EW, Richart RM et al. (1973) Carcinoma of endometrium. Am J Obstet Gynecol 115:663–676

    PubMed  Google Scholar 

  • Gagnon JD, Moss WT, Gabourel LS, Stevens KR (1979) External irradiation in the management of stage II endometrial carcinoma. Cancer 44:1247–1251

    Article  PubMed  CAS  Google Scholar 

  • Giammalvo JT, Kaplan K (1958) The incidence of endometriosis interna in 120 cases of carcinoma of the endometrium. Am J Obstet Gynecol 75:161–166

    PubMed  CAS  Google Scholar 

  • Greenwood SM (1976) The relation of adenomyosis uteri to coexistent endometrial carcinoma and endometrial hyperplasia. Obstet Gynecol 48:68–72

    PubMed  CAS  Google Scholar 

  • Grilli S, Ferrari AM, Gola G et al. (1977) Cytoplasmic receptors for 17β-estradiol, 5α-dihydrotestosterone and progesterone in normal and abnormal human uterine tissue. Cancer Lett 2:247–258

    Article  PubMed  CAS  Google Scholar 

  • Gusberg SB, Yannopoulos D (1964) Therapeutic decision in corpus cancer. Am J Obstet Gynecol 88:157–162

    PubMed  CAS  Google Scholar 

  • Gusberg SB (1978) Cancer of the endometrium: diagnosis and histogenesis. Corscaden’s gynecologic cancer, 5th edn. Williams and Wilkins, Baltimore, p 265–300

    Google Scholar 

  • Hall JB, Young RH, Nelson JH (1984) The prognostic significance of adenomyosis in endometrial carcinoma. Gynecol Oncol 17:32–40

    Article  PubMed  CAS  Google Scholar 

  • Hawksworth W (1964) The treatment of carcinoma of the body of the uterus. Proc R Soc Med 57:467–478

    Google Scholar 

  • Healy WR, Brown RL (1939) Experience with surgical and radiation therapy in carcinoma of the corpus uteri. Am J. Obstet Gynecol 38:1

    Google Scholar 

  • Hernandez E, Woodruff JD (1980) Endometrial adenocarcinoma arising in adenomyosis. Am J Obstet Gynecol 138:827–832

    PubMed  CAS  Google Scholar 

  • Homesley HD, Boronow RC, Lewis JL (1976) Treatment of adenocarcinoma of the endometrium at Memorial-James Ewing Hospital 1949–1965. Obstet Gynecol 47:100–105

    PubMed  CAS  Google Scholar 

  • Homesley HD, Boronow RC, Lewis JL Jr. (1977) Stage II endometrial adenocarcinoma: Memorial Hospital for cancer, 1949–1965. Obstet Gynecol 49:604–608

    PubMed  CAS  Google Scholar 

  • Hunter RE, Longcope C, Jordon VC (1980) Steroid hormone receptors in adenocarcinoma of the endometrium. Gynecol Oncol 10:152–161

    Article  PubMed  CAS  Google Scholar 

  • Joelsson I, Levine RV, Moberger G (1971) Hysteroscopy as an adjunct in determining the extent of carcinoma of the endometrium. Am J Obstet Gynecol 111:696–702

    PubMed  CAS  Google Scholar 

  • Johnsson JE (1979) Recurrences and metastasis in carcinoma of the uterine body correlated to the size and localization of the primary tumor. Acta Obstet Gynecol Scand 58:405–408

    Article  PubMed  CAS  Google Scholar 

  • Jones HW (1975) Treatment of adenocarcinoma of the endometrium. Obstet Gynecol Surv 30:147–169

    Article  PubMed  Google Scholar 

  • Kauppila A, Grönroos M, Niemineu U (1982) Clinical outcome of endometrial cancer. Obstet Gynecol 60:473–480

    PubMed  CAS  Google Scholar 

  • Keller D, Kempson RL, Levine G, McLennan C (1974) Management of the patient with early endometrial carcinoma. Cancer 33:1108–1116

    Article  PubMed  CAS  Google Scholar 

  • Lewis BV, Stallworthy JA, Cowdell R (1970) Adenocarcinoma of the body of the uterus. J Obstet Gynecol Br Commonw 77:343–348

    Article  CAS  Google Scholar 

  • Li SY (1988) Prognosis of endometrial carcinoma. In: Li SY (ed) Endometrial carcinoma. People’s Medical Publishing House, Beijing, p 169–198

    Google Scholar 

  • Li SY, Liu ZM (1984) Estrogen and progesterone receptor in endometrial carcinoma and treatment with 17a-hydroxyprogesterone caproate. J Chin Oncol 6:429–431

    CAS  Google Scholar 

  • Li SY, Wang EY, Li JX et al. (1988) Estrogen receptor and progesterone receptor assay as an index of response to hormone therapy in endometrial cancer. J Practical Oncol 2(4):28–32

    Google Scholar 

  • Lutz MH, Underwood PB Jr, Kreutner A Jr, Miller MC (1978) Endometrial carcinoma: a new method of classification of therapeutic and prognostic significance. Gynecol Oncol 6:83–94

    Article  PubMed  CAS  Google Scholar 

  • MacLaughlin DT, Richardson GS (1976) Progesterone binding by normal and abnormal human endometrium. J Clin Endocrinol Metab 42:667–678

    Article  PubMed  CAS  Google Scholar 

  • Malkasian GD, Annegers JF, Fountain KS (1980) Carcinoma of the endometrium: stage I. Am J Obstet Gynecol 136:872–888

    PubMed  Google Scholar 

  • Manetta A, Delgado G, Petrilli E et al. (1986) The significance of paraaortic node status in carcinoma of the cervix and endometrium. Gynecol Oncol 23:284–290

    Article  PubMed  CAS  Google Scholar 

  • Marcus CC (1962) Relationship of adenomyosis uteri to endometrial hyperplasia and endometrial carcinoma. Am J Obstet Gynecol 82:408–416

    Google Scholar 

  • Martin PM, Rolland PH, Gammerre M et al. (1979) Estradiol and progesterone receptors, histopathological examinations and clinical responses under progestin therapy. Int J Cancer 23:321–329

    Article  PubMed  CAS  Google Scholar 

  • Mattingly RF (1977) Malignant tumors of the uterus. Mattingly RF, Thompson JD (eds) In: Telinde’s Operative Gynecology, 5th edn. Lippincott, Philadelphia, p 845–876

    Google Scholar 

  • McCarty KS Jr, Barton TK, Fetter BF et al. (1979) Correlation of estrogen and progesterone receptors with histological differentiation in endometrial adenocarcinoma. Am J pathol 96:171–182

    PubMed  Google Scholar 

  • Milton PJD, Metters JS (1972) Endometrial carcinoma — an analysis of 355 patients treated at St Thomas Hospital, 1945–1969. J Obstet Gynecol Br Commonw 79:455

    Article  CAS  Google Scholar 

  • Molitor JJ (1971) Adenomyosis: a clinical and pathological appraisal. Am J Obstet Gynecol 110:275–282

    PubMed  CAS  Google Scholar 

  • Mori T, Silverberg SG (1984) Endometrial carcinoma: nontumor factors in prognosis. Gynecol Oncol 17:259

    Article  Google Scholar 

  • Morrow CP, DiSaia PJ, Townsend DE (1973) Current management of endometrial carcinoma. Obstet Gynecol 42:399–408

    PubMed  CAS  Google Scholar 

  • Morrow CP, Creasman WT, Homesley H et al. (1986) Recurrence in endometrial carcinoma as a function of extended surgical staging data. In: Morrow CP, Smart GE (eds) Gynecological oncology. Springer, Berlin Heidelberg New York, p 147–153

    Chapter  Google Scholar 

  • Nahhas WA, Lund CJ, Rudolph JH (1971) Carcinoma of the corpus uterine: a 10-year review of 225 patients. Obstet Gynecol 38:564–570

    Article  PubMed  CAS  Google Scholar 

  • Ng ABP, Reagan JW (1970) Incidence and prognosis of endometrial carcinoma by histologic grade and extent. Obstet Gynecol 35:437–443

    PubMed  CAS  Google Scholar 

  • Nilson PA, Koller O (1969) Carcinoma of the endometrium in Norway, 1957–1960, with special reference to treatment results. Am J Obstet Gynecol 105:1099–1109

    Google Scholar 

  • Nolan JF, Huen A (1976) Prognosis in endometrial cancer. Gynecol Oncol 4:384–390

    Article  PubMed  CAS  Google Scholar 

  • Ostor AG, Adam R, Gutteridge BH et al. (1982) Endometrial carcinoma in young women. Aust NZ J Obstet Gynecol 22:38–42

    Article  CAS  Google Scholar 

  • Owelabi TO, Stickler RC (1977) Adenomyosis - a neglected diagnosis. Obstet Gynecol 50:424–427

    Google Scholar 

  • Piver MS, Lele SB, Barlow JJ et al. (1982) Paraaortic lymph node evaluation in stage I endometrial carcinoma. Obstet Gynecol 59:97–100

    PubMed  CAS  Google Scholar 

  • Plentl AA, Friedman AE (1971) Lymphatic system of the female genitalia. Saunders, Philadelphia, p 135

    Google Scholar 

  • Prem KA, Adcock LL, Okagaki T, Jones TK (1979) The evolution of a treatment program for adenocarcinoma of the endometrium. Am J Obstet Gynecol 133:803

    PubMed  CAS  Google Scholar 

  • Prodi G, DeGiovanni C, Galli MC et al. (1979) 17β-Estradiol, 5α-dihydrotestosterone, progesterone and cortisol receptors in normal and neoplastic human endometrium. Tumori 65:241–253

    PubMed  CAS  Google Scholar 

  • Reagan JW, Fu YS (1981) Pathology of endometrial carcinoma. In: Coppleson M (ed) Gynecologic oncology. Churchill Livingstone, Edinburgh, p. 546–570

    Google Scholar 

  • Rutledge FN (1974) The role of radical hysterectomy in adenocarcinoma of the endometrium. Gynecol Oncol. 2:331–347

    Article  PubMed  CAS  Google Scholar 

  • Sall S, Sonnenblick B, Stone ML (1970) Factors affecting survival of patients with endometrial adenocarcinoma. Am J Obstet Gynecol 107:116–123

    PubMed  CAS  Google Scholar 

  • Silverberg SG, Bolin MG, DeGiorgi LS (1972) Adenoacanthoma and mixed adenosquamous carcinoma of the endometrium: a clinico-pathological study. Cancer 30:1307–1314

    Article  PubMed  CAS  Google Scholar 

  • Silverberg SG, Makowski EL (1975) Endometrial carcinoma in young women taking oral contraceptive agents. Obstet Gynecol 46:503–506

    PubMed  CAS  Google Scholar 

  • Sommers SC (1973) Carcinoma of endometrium. In: Norris JH, Hertig AT, Abell MR (eds) The uterus. Williams and Wilkins, Baltimore, p 276–298

    Google Scholar 

  • Soutter WP, Hamilton K, Leake RE (1979) High affinity binding of estradiol-17β in the nuclei of human endometrial cells. J Steroid Biochem 10:529–534

    Article  PubMed  CAS  Google Scholar 

  • Spona J, Ulm R, Bieglmayer C, Husslein P (1979) Hormone serum levels and hormone receptor contents of endometria in women with normal menstrual cycles and patients bearing endometrial carcinoma. Gynecol Obstet Invest 10:71–80

    Article  PubMed  CAS  Google Scholar 

  • Surwit EA, Fowler WC Jr, Rogoff EE (1978) Stage II carcinoma of the endometrium: an analysis of treatment. Obstet Gynecol 52:97–99

    PubMed  CAS  Google Scholar 

  • Surwit EA, Joelsson I, Einhorn N (1981) Adjunctive radiation therapy in the management of stage I cancer of the endometrium. Obstet Gynecol 58:590–595

    PubMed  CAS  Google Scholar 

  • Trotnow S, Becker H, Paterok EM (1978) Tumour volume of endometrial cancer. In: Brush M, Taylor RW (eds) Endometrial cancer. Baillière Tindall, Eastbourne

    Google Scholar 

  • Vongtama V, Kurohara SS, Badib AO, Webster JH (1970) The value of adjuvant irradiation in the treatment of endometrial carcinoma stage I group 1. Cancer 25:45–49

    Article  PubMed  CAS  Google Scholar 

  • Wade ME, Kohorn EI, Morris JM (1967) Adenocarcinoma of the endometrium: evaluation of preoperative irradiation and factors influencing prognosis. Am J Obstet Gynecol 99:869–876

    PubMed  CAS  Google Scholar 

  • Wallin TE, Malkasian GD, Gaffey TA et al. (1984) Stage II cancer of the endometrium: a pathologic and clinical study. Gynecol Oncol 18:1–17

    Article  PubMed  CAS  Google Scholar 

  • Weed JC, Greary WL, Holland JB (1966) Adenomyosis of the uterus. Clin Obstet Gynecol 9:412–421

    Article  PubMed  CAS  Google Scholar 

  • Weiser EB, Hoskins WJ, Bibro MC et al. (1985) Papillary adenocarcinoma of the endometrium. Gynecol Oncol 20:249

    Article  Google Scholar 

  • Welander CA, Griem ML, Newton M, Marks JE (1972) Staging and treatment of endometrial carcinoma. J Reprod Med 8:41–46

    PubMed  CAS  Google Scholar 

  • Wu BZ, Tang MY, Lang JH (1982) Endometrial carcinoma. In: Lin QZ (ed) Gynecologic oncology. People’s Medical Publishing House, Beijing, p 85–104

    Google Scholar 

  • Yazigi R, Piver MS, Blumenson L (1983) Malignant peritoneal cytology as prognostic indicator in stage I endometrial cancer. Obstet Gynecol 62:359–362

    Article  PubMed  CAS  Google Scholar 

  • Yoonessi M, Anderson DG, Morley GW (1979) Endometrial carcinoma: causes of death and sites of treatment failure. Cancer 43:1944–1950

    Article  PubMed  CAS  Google Scholar 

  • Young PCM, Ehrlich CE (1979) Progesterone receptors in human endometrial cancer. In: Thompson EB, Lippman ME (eds) Steroid receptors and the management of cancer, Vol I. CRC Press, Boca Raton, p 135–160

    Google Scholar 

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  1. Gynecologic Oncology Department, Cancer Institute (Hospital) Chinese Academy of Medical Sciences, Beijing, 100021, P.R.China

    Dr. Shen-yi Li (Associate Professor, Chief of Medical Affairs Branch) & Dr. En-yu Wang (Associate Professor)

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  1. Dr. Shen-yi Li
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  2. Dr. En-yu Wang
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© 1990 The People’s Medical Publishing House Beijing and Springer-Verlag Berlin Heidelberg

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Li, Sy., Wang, Ey. (1990). Prognosis of Endometrial Carcinoma. In: Endometrial Carcinoma. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74821-9_5

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  • DOI: https://doi.org/10.1007/978-3-642-74821-9_5

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