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Treatment of Endometrial Carcinoma

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Endometrial Carcinoma

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Abstract

Nearly one century has passed since Thomas Cullen, in his book Cancer of the Uterus published in 1900, described the treatment of endometrial carcinoma with abdominal hysterectomy and bilateral salpingo-oophorectomy and recommended vaginal hysterectomy only in the very obese or medically indigent patients. In the 1920s, Healy was one of the first to study the effects of radiation alone and in combination with surgery in the treatment of endometrial carcinoma. It confirmed that poorly differentiated carcinoma was more difficult to be treated successfully. In 1936, Arneson compared radiation plus surgery with surgery and radiation alone and found that the combination of radiation, followed 3–6 weeks later by hysterectomy was the best method to treat cancer of the corpus uteri and yielded improved 5-year survival. In 1941 Heyman developed a technique of packing the uterus with multiple capsules of radium prior to hysterectomy and showed approximately 60% 5-year survivals in stage I patients.

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References

  • Aalders JG, Abeler V, Kolstad P (1984) Recurrent adenocarcinoma of the endometrium: a clinical and histopathological study of 379 patients. Gynecol Oncol 17:85–103

    PubMed  CAS  Google Scholar 

  • Anderson DG (1965) Management of advanced endometrial adenocarcinoma with medroxyprogesterone acetate. Am J Obstet Gynecol 92:87–97

    PubMed  CAS  Google Scholar 

  • Anderson DG (1972) The possible mechanisms of action of progestins on endometrial adenocarcinoma. Am J Obstet Gynecol 113:195–211

    PubMed  CAS  Google Scholar 

  • Annegers J, Malkasian G (1981) Patterns of other neoplasia in patients with endometrial carcinoma. Cancer 48:856–859

    PubMed  CAS  Google Scholar 

  • Arneson A (1936) Clinical results and histologic changes following the radiation treatment of cancer of the corpus uteri. Am J Roentgenol 36:461

    Google Scholar 

  • Ayoub J, Audet-Lapointe P, Methot Y et al. (1986) Randomized trial of the addition of cyclical hormonal therapy to combination chemotherapy for advanced endometrial cancer. Gynecol Oncol 23:255

    Google Scholar 

  • Badib AO, Kurohara SS, Vongtama VY, Webster JH (1969) Evaluation of primary radiation therapy in stage I, group 2 endometrial carcinoma. Radiology 93:417–421

    PubMed  CAS  Google Scholar 

  • Barni S, Novelli GC, Zanoio L et al. (1981) Chromatin analysis in human endometrial adenocarcinoma before and after treatment with MPA. Virchows Arch (Cell Pathol) 37:167–177

    CAS  Google Scholar 

  • Beck RP, Latour JPA (1963) Necropsy reports on 36 cases of endometrial carcinoma. Am J Obstet Gynecol 85:307–311

    PubMed  CAS  Google Scholar 

  • Beiler DD, Schmutz DA, O’Rourke TL (1972) Carcinoma of the endometrium: radiation and surgery versus surgery alone. Radiology 102:159–164

    PubMed  CAS  Google Scholar 

  • Berman ML, Barlow SC, Lagasse LD et al. (1980) Prognosis and treatment of endometrial cancer. Am J Obstet Gynecol 136:679–688

    PubMed  CAS  Google Scholar 

  • Berman ML, Afridi MA, Kanbour AL, Ball HG (1982) Risk factors and prognosis in stage II endometrial cancer. Gynecol Oncol 14:49–61

    PubMed  CAS  Google Scholar 

  • Binart N, Mester J, Baulier EE, Catelli MG (1982) Combined effects of progesterone and Tamoxifen in the chick oviduct. Endocrinology 111:7–16

    PubMed  CAS  Google Scholar 

  • Bojar H, Stusckhe M, Staib W (1983) Effects of high-dose medroxyprogesterone acetate (MPA) on plasma membrane lipid mobility. J Steroid Biochem [Suppl] 19:107

    Google Scholar 

  • Bokhman JV, Chepick OF, Volkova AT, Vishnevsky AS (1981) Adjuvant hormone therapy of primary endometrial carcinoma with oxyprogesterone caproate. Gynecol Oncol 11:371–378

    PubMed  CAS  Google Scholar 

  • Bokhman JV, Chepick OF, Volkova AT, Vishnevsky AS (1985) Can primary endometrial carcinoma stage I be cured without surgery and radiation therapy? Gynecol Oncol 20:139–155

    PubMed  CAS  Google Scholar 

  • Bonte J, Kohorn I (1978) The response of hyperplastic, dysplastic and neoplastic endometrium to progestational therapy. In: Richardson GS, MacLaughlin DT (eds) Hormone biology of endometrial cancer. UICC, Geneva, p 155–184

    Google Scholar 

  • Bonte J (1979) Developments in endocrine therapy of endometrial and ovarian cancer. Rev Endocrin Relat Cancer 3:11–17

    Google Scholar 

  • Bonte J (1980) Hormonal dependence of endometrial adenocarcinoma and its hormonal sensitivity to progesterone and antiestrogens. Prog Cancer Res Ther 14:443–455

    Google Scholar 

  • Bonte J, Ide P, Billiet G, Wynants P (1981) Tamoxifen as a possible chemotherapeutic agent in endometrial adenocarcinoma. Gynecol Oncol 11:140–161

    PubMed  CAS  Google Scholar 

  • Bonte J (1983) Hormone dependency and hormone responsiveness of endometrial adenocarcinoma to estrogens, progesterone and antiestrogens. In: Campio L, Robustelli G, Cuna D, Taylor RW (eds) Role of medroxyprogesterone in endocrine-related tumors, vol II. Raven, New York, p 141–156

    Google Scholar 

  • Bonte J (1984) The endometrial adenocarcinoma as a model for hormone-dependency and hormone-responsiveness of gynaecological cancers. Eur J Obstet Gynecol Reprod Biol 18:335–341

    PubMed  CAS  Google Scholar 

  • Bonte J (1985) Hormone treatment of gynecological tumors. In: Williams CJ, White-house JMA (eds) Cancer investigation and management, vol 3: cancer of the female reproductive system. Wiley, New York, p 141

    Google Scholar 

  • Boronow RC (1969) Carcinoma of the corpus: treatment at MD Anderson Hospital, in cancer of the uterus and ovary (Anderson Hospital). Year Book Medical Publishers, Chicago, p 35–61

    Google Scholar 

  • Boronow RC, Morrow CP, Creasman WT et al. (1984) Surgical staging of endometrial cancer: 1. Clinical-pathologic findings of a prospective study. Obstet Gynecol 63:825–838

    PubMed  CAS  Google Scholar 

  • Broens J, Mouridsen HT, Soerensen HM (1980) Tamoxifen in advanced endometrial carcinoma. Cancer Chemother Pharmacol 4:213

    PubMed  CAS  Google Scholar 

  • Bruckner HW, Deppe G (1977) Combination chemotherapy of advanced endometrial carcinoma with adriamycin, cyclophosphamide, 5-fluorouracil, and medroxyprogesterone acetate. Obstet Gynecol 50:10–125

    Google Scholar 

  • Brunschwig A, Murphy AI (1954) The rationale for radical panhysterectomy and pelvic node excision in carcinoma of the corpus uteri. Am J Obstet Gynecol 68:1482–1488

    PubMed  CAS  Google Scholar 

  • Caffier H, Horner G, Baum RJ (1982) Treatment of advanced or recurrent endometrial adenocarcinoma with progestins, including medroxyprogesterone acetate. In: Proceedings of the international symposium on medroxyprogesterone acetate. Excerpta Medica, Geneva, 389–396

    Google Scholar 

  • Chau PM (1962) Technic and evaluation of preoperative radium therapy in adenocarcinoma of the uterine corpus. In: Carcinoma of the uterine cervix, endometrium and ovary. Year Book Medical Publishers, Chicago, p 235

    Google Scholar 

  • Christensen C, Malviya V, Deppe G et al. (1985) RL-95: a model for chemotherapeutic agents in endometrial adenocarcinoma. Gynecol Oncol 20:266

    Google Scholar 

  • Cohen CJ, Bruckner HW, Deppe G et al. (1984) Multidrug treatment of advanced and recurrent endometrial carcinoma: a gynecologic oncology group study. Obstet Gynecol 63:719–726

    PubMed  CAS  Google Scholar 

  • Connelly PJ, Alberhasky RC, Christopherson WM (1982) Carcinoma of the endometrium III. Analysis of 865 cases of adenocarcinoma and adenoacanthoma. Obstet Gynecol 59:569–575

    PubMed  CAS  Google Scholar 

  • Creasman WT, Rutledge FN (1971) The prognostic value of peritoneal cytology in gynecologic malignant disease. Am J Obstet Gynecol 110:773–781

    PubMed  CAS  Google Scholar 

  • Creasman WT, Weed JC Jr (1981) Carcinoma of endometrium (FIGO Stage I and II): clinical features and management. In: Coppleson M (ed) Gynecologic oncology, fundamental principles and clinical practice. Churchill Livingstone, Edinbourgh, p 571–577

    Google Scholar 

  • Creasman WT, Boronow RC, Morrow CP et al. (1976) Adenocarcinoma of the endometrium: its metastatic, lymph node potential. Gynecol Oncol 4:239–243

    PubMed  CAS  Google Scholar 

  • Creasman WT, DiSaia PJ, Blessing T et al. (1981) Prognostic significance of peritoneal cytology in patients with endometrial cancer and preliminary data concerning therapy with intraperitoneal radiopharmaceuticals. Am J Obstet Gynecol 141:921–929

    PubMed  CAS  Google Scholar 

  • Creasman WT, Henderson D, Clarke-Pearson DL (1984) Use of estrogen after treatment for adenocarcinoma of the endometrium. Gynecol Oncol 17:255

    Google Scholar 

  • Cullen TH (1900) Cancer of the uterus. Philadelphia, Saunders.

    Google Scholar 

  • Dahle R (1956) Transtubal spread of tumor cells in carcinoma of the body of the uterus. Surg Gynecol Obstet 102:332

    Google Scholar 

  • Delclos L, Braun EJ, Herrera JR et al. (1963) Whole abdominal irradiation by cobalt-60 moving-step technic. Radiology 81:632–641

    PubMed  CAS  Google Scholar 

  • Delclos L, Fletcher GH (1969) Malignant tumors of the endometrium: evaluation of some aspects of radiotherapy, M. D. Anderson Hospital. In: Cancer of the uterus and ovary 11th clinical conference on cancer, M. D. Anderson Hospital and Tumor Institute, Houston, 1966. Year Book Medical Publishers, Chicago, p 62–72

    Google Scholar 

  • Dembo AJ, Van Dyk J, Japp B et al. (1979) Whole abdominal irradiation by a moving-strip technique for patients with ovarian cancer. Int J Radiat Oncol Biol Phys 5:1933–1942

    PubMed  CAS  Google Scholar 

  • Deppe G (1982) Chemotherapeutic treatment of endometrial carcinoma. Clin Obstet Gynaecol 25:93–99

    CAS  Google Scholar 

  • Devita VT, Wasserman TH, Young RC, Carter SK (1976) Perspectives on research in gynecologic oncology. Cancer 38:509–525

    PubMed  Google Scholar 

  • Dobbie BMW (1953) Vaginal recurrences in carcinoma of the body of the uterus and their prevention by radium therapy. J Obstet Gynecol Br Commonw 60:702–705

    CAS  Google Scholar 

  • Du Toit JP (1985) Carcinoma of the uterine body. In: Shepherd JH, Monaghan JM (eds) Clinical gynecological oncology. Blackwell, Oxford, p 97–132

    Google Scholar 

  • Enk L, Crona N, Friberg LG et al. (1985) High-dose depot-medroxyprogesterone acetate - effects on the fatty acid composition of serum lecithin and cholesterol ester. Gynecol Oncol 22:317–323

    PubMed  CAS  Google Scholar 

  • Ferenczy A (1977) Surface ultrastructural response of the human uterine lining epithelium to homonal environment. A scanning electron microscopic study. Acta Cytol 21:566–572

    PubMed  CAS  Google Scholar 

  • Ferrazzi E, Cartei G, Mattazazzo R, Fiorentino M (1977) Oestrogen-like effect of tamoxifen on vaginal epithelium (letter). Br Med J 1:1351–1352

    PubMed  CAS  Google Scholar 

  • FIGO (1985) Annual report on the results of the treatment in gynecological cancer, vol 18. Statements of results obtained in 1973–1975. Radium hemmet, Stockholm

    Google Scholar 

  • Frick HC, Munnell EW, Richart RM et al. (1973) Carcinoma of endometrium. Am J Obstet Gynecol 115:663–676

    PubMed  Google Scholar 

  • Gagnon JD, Moss WT, Gabourel LS, Stevens KR (1979) External irradiation in the management of stage II endometrial carcinoma. Cancer 44:1247–1251

    PubMed  CAS  Google Scholar 

  • Geisler HE (1973) The use of megestrol acetate in the treatment of advanced malignant lesions of the endometrium. Gynecol Oncol 1:340

    Google Scholar 

  • Graham J (1971) The value of preoperative or postoperative treatment by radium for carcinoma of the uterine body. Surg Gynecol Obstet 132:855–860

    PubMed  CAS  Google Scholar 

  • Gravanis A, Binart P, Robel P et al. (1984) Estrogen-like effects of combined dexametha-sone and tamoxifen in the chick oviduct. Biochem Biophys Res Commun 124:57–62

    PubMed  CAS  Google Scholar 

  • Groom GV, Griffiths K (1976) Effect of the anti-oestrogen tamoxifen on plasma levels of luteinizing hormone, follicle-stimulating hormone, prolactin, oestradiol and progesterone in normal pre-menopausal women. J Endocrinol 70:421–428

    PubMed  CAS  Google Scholar 

  • Gurpide E, Tseng L (1977) Estrogen metabolism in normal and neoplastic endometrium. Am J Obstet Gynecol 129:809–816

    PubMed  CAS  Google Scholar 

  • Gurpide E (1979) Hormonal aspects of carcinoma of the endometrium. Gynecol Cancer 8:191–198

    CAS  Google Scholar 

  • Gurpide E (1981) Hormone receptors in endometrial cancer. Cancer 48:638–641

    PubMed  CAS  Google Scholar 

  • Gusberg SB, Yannopoulos D (1964) Therapeutic decision in corpus cancer. Am J Obstet Gynecol 88:157–162

    PubMed  CAS  Google Scholar 

  • Hald I (1981) The use of tamoxifen (‘Novadex’) in endometrial cancer. Rev Endocrin Relat Cancer [Suppl] 8:9–15

    Google Scholar 

  • Healy WP (1939) Experience with surgical radiation therapy in carcinoma of the corpus uteri. Am J Obstet Gynecol 38:1

    Google Scholar 

  • Henriksen E (1949) The lymphatic spread of carcinoma of the cervix and of the body of the uterus; a study of 420 necropsies. Am J Obstet Gynecol 58:924–940

    PubMed  CAS  Google Scholar 

  • Heyman J (1947) Improvement of results in the treatment of uterine cancer. J Am Hosp Ass 135:412–416

    CAS  Google Scholar 

  • Heyman J, Reuterwall O, Beuner S (1941) The Radiumhemmet experience with radiotherapy in cancer of the corpus of the uterus: classification, method of treatment and results. Acta Radiol 22:11–98

    Google Scholar 

  • Holincka CF, Gurpide E (1980) Peroxidase activity in glands and stroma of human endometrium. Am J Obstet Gynecol 138:599–603

    Google Scholar 

  • Horton J, Bezz CB, Arsenean J et al. (1978) Comparison of adriamycin with cyclophosphamide in patients with advanced endometrial cancer. Cancer Treat Rep 62:154–161

    Google Scholar 

  • Iacobelli S, Sica G, Natoli C, Gatti D (1983) Inhibitory effects of medroxyprogesterone acetate on the proliferation of human breast cancer cells. In: Campio L, Robustelli G, Cuna D, Taylor RW (eds) Role of medroxyprogesterone in endocrine-related tumors, vol 2. Raven, New York, p 1–6

    Google Scholar 

  • Ishiwata I, Nozawa S, Okumura H (1977) Effects of 17β-estradiol and progesterone on growth and morphology of human endometrial carcinoma cells in vitro. Cancer Res 37:4246–4249

    PubMed  CAS  Google Scholar 

  • Janne O (1979) Female sex steroid receptors in normal hyperplastic and carcinomatous endometrium. The relationship to serum steroid hormones and gonadotropins and changes during medroxyprogesterone acetate administration. Int J Cancer 24:545–554

    PubMed  CAS  Google Scholar 

  • Jones HW (1975) Treatment of adenocarcinoma of the endometrium. Obstet Gynecol Surv 30:147–169

    PubMed  Google Scholar 

  • Jordan VC, Dix CJ (1978) Effect of estradiol benzoate, tamoxifen and monohydroxy-tamoxifen on immature rat uterine progesterone receptor synthesis and endometrial cell division. J Steroid Biochem 11:285–291

    Google Scholar 

  • Joslin CAF (1985) The place for radiotherapy in endometrial cancer. Proceedings of International Meeting of Gynaecological Oncology, Venice-Lido (Italy) Apr 1985, p21–24

    Google Scholar 

  • Joslin CAF, Vaishampayan GV, Mallik T (1977) The treatment of early cancer of the corpus uteri. Radiology 50:38–45

    CAS  Google Scholar 

  • Kadar NRD, Kohom EI, LiVolsi VA, Kapp DS (1982) Histologic variants of cervical involvement by endometrial carcinoma. Obstet Gynecol 59:85–92

    PubMed  CAS  Google Scholar 

  • Kauppila A, Fribert LG (1981) Hormone and cytotoxic chemotherapy for endometrial carcinoma. Acta Obstet Gynecol Scand [Suppl] 101:59–64

    CAS  Google Scholar 

  • Kauppila A, Gronroos M, Niemineu U (1982) Clinical outcome of endometrial cancer. Obstet Gynecol 60:473–480

    PubMed  CAS  Google Scholar 

  • Keettel WC, Pixley EE, Buchsbaum HJ (1974) Experience with peritoneal cytology in the management of gynecological malignancies. Am J Obstet Gynecol 120:174–182

    PubMed  CAS  Google Scholar 

  • Kelley RM (1951) Proceedings of the second conference on steroids and cancer, Council on Pharmacy and Chemistry, American Medical Association Chicago, 116

    Google Scholar 

  • Kelley RM, Baker WH (1961) Progestational agents in the treatment of carcinoma of the endometrium. N Engl J Med 264:216–222

    PubMed  CAS  Google Scholar 

  • Kennedy A, Peterson G, Becker S, Webster K (1986) Experience with pelvic washings in stage I and II endometrial adenocarcinoma. Gynecol Oncol 23:256

    Google Scholar 

  • Kinsella TJ, Bloomer WD, Lavin PT et al. (1980) Stage II endometrial carcinoma: ten year follow up combined radiation and surgical treatment. Gynecol Oncol 11:290–297

    Google Scholar 

  • Kistner RW, Griffiths CT, Craig JM (1965) Use of progestational agents in the management of endometrial cancer. Cancer 18:1563–1579

    PubMed  CAS  Google Scholar 

  • Kjellgren O, Magnusson SS (1970) Efficacy of primary radiation in carcinoma of the endometrium. Acta Radiol 9:102–104

    CAS  Google Scholar 

  • Kohorn El (1976) Gestagens and endometrial carcinoma. Gynecol Oncol 4:398–411

    PubMed  CAS  Google Scholar 

  • Lampe I (1963) Endometrial carcinoma. Am J Roentgenol 90:1011–1015

    CAS  Google Scholar 

  • Laatikainen T, Nieminea U, Adlercreutz H (1979) Plasma medroxyprogesterone acetate levels following intramuscular or oral administration in patients with endometrial adenocarcinoma. Acta Obstet Gynecol Scand 58:85–99

    Google Scholar 

  • Lewis B, Stallworthy JA, Cowdell R (1970) Adenocarcinoma of the body of the uterus. J Obstet Gynecol Br Commonw 77:343–348

    CAS  Google Scholar 

  • Lewis GC, Slack NH et al. (1974) Adjuvant progestogen therapy in the primary definitive treatment of endometrial cancer. Gynecol Oncol 2:368–376

    PubMed  Google Scholar 

  • Li SY (1988) Treatment. In: Li SY (ed) Endometrial carcinoma. People’s Medical Publishing House, Beijing, p 94–168

    Google Scholar 

  • Lloyd RE, Jones SE, Sammon SE (1975) Southwest oncology group members: “Phase II trial of adriamycin and cyclophosphamide: a southwest oncology group pilot study”. Proc Am Assoc Cancer Res 16:265

    Google Scholar 

  • Lovecchio JL, Averette HE, Lichtinger M et al. (1984) Treatment of advanced or recurrent endometrial adenocarcinoma with cyclophosphamide, doxorubicin, cis-platinum and megestrol acetate. Obstet Gynecol 63:557–560

    PubMed  CAS  Google Scholar 

  • Malkasian GD, Decker DG, Mussey E, Johnson CG (1971) Progestin treatment of recurrent endometrial carcinoma. Am J Obstet Gynecol 110:15–23

    PubMed  CAS  Google Scholar 

  • Marchesoni D, Mozzanega B, Gangemi M, Enrichi H (1980) Tamoxifen in the therapy of post-menopausal endometrial cancer: variations in some hormonal parameters. Eur J Gynaecol Oncol 1:116–121

    PubMed  CAS  Google Scholar 

  • Marcial VA, Tome JM, Ubinas J (1969) The combination of external irradiation and curietherapy used preoperatively in adenocarcinoma of the endometrium. Am J Roentgenol Nucl Med 105:586–595

    CAS  Google Scholar 

  • Martin PM, Rolland PH, Jacquemier J et al. (1979) Multiple steroid receptors in human breast cancer. II. Estrogen and progesterone receptors in 672 primary tumors. III. Relationship between steroid receptors and the state of differentiation and the activity of carcinomas throughout the pathologic feature. Cancer Chemother Pharmacol 2:107–120

    PubMed  CAS  Google Scholar 

  • Masson JC, Gregg RD (1940) Carcinoma of the body of the uterus: experience of the Mayo Clinic for 24 years. Surg Gynecol Obstet 70:1083

    Google Scholar 

  • McCabe JG, Sagerman RH (1979) Treatment of endometrial cancer in a regional radiation therapy center. Cancer 43:1052–1057

    PubMed  CAS  Google Scholar 

  • McGrew EA, Laws JF, Coles WH (1954) Free malignant cells in relation to recurrence of carcinoma of the colon. JAMA 154:1251

    CAS  Google Scholar 

  • Milton PJD, Metters JS (1972) Endometrial carcinoma - an analysis of 355 patients treated at St. Thomas’ Hospital, 1945–1969. J Obstet Gynecol Br Commonw 79:455–464

    CAS  Google Scholar 

  • Moazzami B, Van der Walt JD, Boyd NR (1983) Use of progestogens as an adjuvant to surgery in the treatment of stage I adenocarcinoma of the uterine corpus. Br J Obstet Gynaecol 90:178–181

    PubMed  CAS  Google Scholar 

  • Morrow CP, DiSaia PJ, Townsend DE (1973) Current management of endometrial carcinoma. Obstet Gynecol 42:399–406

    PubMed  CAS  Google Scholar 

  • Morrow CP, Townsend DE (1981) Cancer of the uterine corpus. In: Synopsis of gynecologic oncology. Wiley, New York, p 133

    Google Scholar 

  • Morrow CP, Schlaerth JB (1982) Surgical management of endometrial carcinoma. Clin Obstet Gynecol 25:81–92

    PubMed  CAS  Google Scholar 

  • Morrow CP, Creasman WT, Homesley H et al. (1986) Recurrence in endometrial carcinoma as a function of extended surgical staging data (a gynecological oncology group study). In: Morrow CP, Smart Ge (eds) Gynecological oncology. Springer Berlin Heidelberg New York, p 147–153

    Google Scholar 

  • Mortel R, Levy C, Welff JP et al. (1981) Female sex steroid receptors in postmenopausal endometrial carcinoma and biochemical response to an antiestrogen. Cancer 41:1140–1147

    CAS  Google Scholar 

  • Mortel R, Zaino R, Satyaswaroop PG (1984) Response of endometrial carcinoma to sequential treatment with tamoxifen and progestin in the Nude Mouse Model. Gynecol Oncol 17:253–254

    Google Scholar 

  • Mortel R, Zaino RJ, Satyaswaroop PG (1985) Response of human endometrial carcinoma to various doses of estradiol and tamoxifen in the nude mouse model. Gynecol Oncol 20:257

    Google Scholar 

  • Muggia FM, Chia GA, Reed LJ, Romney SL (1977) Doxorubicin-cyclophosphamide: effective therapy for advanced endometrial cancer. Am J Obstet Gynecol 128:314–319

    PubMed  CAS  Google Scholar 

  • Nahhas WA, Whitney CW, Stryker JA et al. (1980) Stage II endometrial carcinoma. Gynecol Oncol 10:303–311

    PubMed  CAS  Google Scholar 

  • Nahhas WA, Zaino R, Mortel R (1984) Residual carcinoma in the surgical specimen of patients with endometrial adenocarcinoma undergoing preoperative radiation therapy. A study of 80 patients and a literature review. Gynecol Oncol 18:165–176

    PubMed  CAS  Google Scholar 

  • Onsrud M, Kolstad P, Normann T (1976) Postoperative external pelvic irradiation in carcinoma of the corpus stage I: a controlled clinical trial. Gynecol Oncol 4:222–231

    PubMed  CAS  Google Scholar 

  • Pannutti F (1981) High doses of medroxyprogesterone acetate in advanced cancer treatment. Plasma levels and bioavailability after single and multiple dose administration, preliminary results. In symposium: role of medroxyprogesterone acetate in endocrine-related tumors, 1981 Rome.

    Google Scholar 

  • Park R, Patow W, Petty W, Zimmermann E (1974) Treatment of adenocarcinoma of the endometrium. Gynecol Oncol 2:60–70

    PubMed  CAS  Google Scholar 

  • Paterson R (1948) The treatment of malignant disease by radium and X-rays: being a practice of radiotherapy. Arnold, London p 249–432

    Google Scholar 

  • Piver MS, Yazigi R, Blumenson LE, Tsukada Y (1979) A prospective trial comparing hysterectomy, hysterectomy plus vaginal radium, and uterine radium plus hysterectomy in stage I endometrial carcinoma. Obstet Gynecol 54:85–89

    PubMed  CAS  Google Scholar 

  • Piver MS (1980) Stage I endometrial carcinoma: the role of adjunctive radiation therapy. Int J Radiat Oncol Biol Phys 6:367–368

    PubMed  CAS  Google Scholar 

  • Piver MS, Barlow JJ, Lurain JR, Blumenson LE (1980) Medroxyprogesterone acetate (Depo-provera) Vs hydroxyprogesterone caproate (Delalutin) in women with metastatic endometrial adenocarcinoma. Cancer 45:268–272

    PubMed  CAS  Google Scholar 

  • Piver MS, Lele SB, Barlow JJ et al. (1982) Para-aortic lymph node evaluation in stage I endometrial carcinoma. Obstet Gynecol 59:97–100

    PubMed  CAS  Google Scholar 

  • Prodi G, Nicoletti G, DeGiovanni C et al. (1980) Multiple steroid hormone receptors in normal and abnormal human endometrium. J Cancer Res Clin Oncol 98:173–183

    PubMed  CAS  Google Scholar 

  • Quinn MA, Campbell JJ, Murray R, Pepperell RJ (1981) Tamoxi fen and aminoglutethimide in the management of patients with advanced endometrial carcinoma not responsive to medroxyprogesterone. Aust NZ J Obstet Gynaecol 21:226–227

    CAS  Google Scholar 

  • Randall JH, Goddard WBA (1956) A study of 531 cases of endometrial carcinoma. Surg Gynecol Obstet 103:221–226

    PubMed  CAS  Google Scholar 

  • Reel JR (1976) The mode of action of progestagens on endometrial carcinoma. In: Steroid hormone action and cancer, vol 4, W 1 CU 82M. Plenum, New York, p 85–94

    Google Scholar 

  • Reifenstein EC (1974) The treatment of advanced endometrial cancer with hydroxyprogesterone caproate. Gynecol Oncol 2:377–414

    PubMed  Google Scholar 

  • Ritcher N, Lucas WE, Yon JL, Sanford GD (1981) Preoperative whole pelvic external irradiation in stage I endometrial cancer. Cancer 48:58–62

    PubMed  CAS  Google Scholar 

  • Robel P, Levy C, Bayard F et al. (1979) Estradiol and progesterone receptors in normal and abnormal human endometrium. In: Klopper et al. (eds) Research on steroids, vol VIII. Academic, London, p 77–85

    Google Scholar 

  • Robel P, Gravanis A, Roger-Jallais L et al. (1986) Receptors, hormones and antihormones in postmenopausal endometrial carcinoma. In: Bolla M, Racinet C, Vrousos C (eds) Endometrial cancers. 5th Cancer Research Workshop, Grenoble 1985. Karger, Basel, p 119–125

    Google Scholar 

  • Rutledge FN (1974) The role of radical hysterectomy in adenocarcinoma of the endometrium. Gynecol Oncol 2:331–347

    PubMed  CAS  Google Scholar 

  • Rutledge FN, Tan SK, Fletcher GM (1958) Vaginal metastasis from adenocarcinoma of the corpus uteri. Am J Obstet Gynecol 75:167–174

    PubMed  CAS  Google Scholar 

  • Sala JM, Del Regato JA (1961) Treatment of carcinoma of the endometrium. Radiology 79:12–17

    Google Scholar 

  • Salazar OM, Feldstein ML, DePapp EW et al. (1978) The management of clinical stage I endometrial carcinoma. Cancer 41:1016–1026

    PubMed  CAS  Google Scholar 

  • Salimtschik M, Mouridsen HT, Loeber J, Johansson E (1980) Comparative pharmacokinetics of MPA administered by oral and i.m. route. Cancer Chemother Pharmacol 4:267–269

    PubMed  CAS  Google Scholar 

  • Sall S, Sonnenblick B, Stone ML (1970) Factors affecting survival of patients with endometrial adenocarcinoma. Am J Obstet Gynecol 107:116–123

    PubMed  CAS  Google Scholar 

  • Sall S, DiSaia P, Morrow CP et al. (1979) A comparison of medroxyprogesterone serum concentrations by the oral or intramuscular route in patients with persistent or recurrent endometrial carcinoma. Am J Obstet Gynecol 135:647–650

    PubMed  CAS  Google Scholar 

  • Satyaswaroop PG, Frost A, Gurpide E (1980) Metabolism and effects of progesterone in the human endometrial adenocarcinoma cell line HEC-1. Steroids 35:21–37

    PubMed  CAS  Google Scholar 

  • Seski JC, Edwards CL, Herson J et al. (1982) Cisplatin chemotherapy in disseminated endometrial cancer. Obstet Gynecol 59:225–228

    PubMed  CAS  Google Scholar 

  • Shimm DS, Wang CC, Fuller AF et al. (1986) Management of high-grade stage I adenocarcinoma of the endometrium: hysterectomy following low dose external beam pelvic irradiation. Gynecol Oncol 23:183–191

    PubMed  CAS  Google Scholar 

  • Silverberg SG, DeGiorgi LS (1974) Histopathologic analysis of preoperative radiation therapy in endometrial carcinoma. Am J Obstet Gynecol 119:698–704

    PubMed  CAS  Google Scholar 

  • Smith JP, Rutledge F, Soffar SW (1966) Progestins in the treatment of patients with endometrial adenocarcinoma. Am J Obstet Gynecol 94:977–984

    PubMed  CAS  Google Scholar 

  • Strickland P (1965) Carcinoma corporis uteri: a radical intracavitary treatment. Clin Radiol 16:112–118

    PubMed  CAS  Google Scholar 

  • Suit HD, Shalek RJ (1963) Response of anoxic C3H mouse mammary carcinoma isotransplants (1–25 mm3) to X irradiation. JNCI 31:479–495

    PubMed  CAS  Google Scholar 

  • Suit HD, Gallager HS (1964) Intact tumor cells in irradiated tissue. Arch Pathol 78:648–651

    PubMed  CAS  Google Scholar 

  • Surwit EA, Joelsson I, Einhorn N (1981) Adjunctive radiation therapy in the management of stage I cancer of the endometrium. Obstet Gynecol 58:590–595

    PubMed  CAS  Google Scholar 

  • Sutherland RL, Mester J, Baulieu EE (1977) Tamoxifen is a potent pure antiestrogen in chick oviduct. Nature 267:434–435

    PubMed  CAS  Google Scholar 

  • Swenerton KD, Shaw D, White GW, Boyes DA (1979) Treatment of advanced endometrial carcinoma with tamoxifen. N Engl J Med 301:105

    PubMed  CAS  Google Scholar 

  • Swenerton KD (1980) Treatment of advanced endometrial adenocarcinoma with tamoxifen. Cancer Treat Rep 64:805–811

    PubMed  CAS  Google Scholar 

  • Tamassia V, Battaglia A, Ganzina F et al. (1982) Pharmacokinetic approach to selection of dose schedules for MPA in clinical oncology. Cancer Chemother Pharmacol 8:151–156

    PubMed  CAS  Google Scholar 

  • Tamassia V (1986) Clinical pharmacokinetics of medroxyprogesterone acetate: relevance for the treatment of breast and endometrial cancer. In: Bolla M, Racinet C, Vrousos C (eds) Endometrial cancers. 5th Cancer Research Workshop, Grenoble 1985. Karger, Basel, p 168–176

    Google Scholar 

  • Taylor HC Jr, Becker WF (1947) Carcinoma of the corpus uteri: end-results of treatment in 531 cases from 1926–1940. Surg Gynecol Obstet 84:129–139

    PubMed  Google Scholar 

  • Thigpen JT, Buchsbaum HJ, Mangan C, Blessing JA (1979) Phase II trial of adriamycin in the treatment of advanced or recurrent endometrial carcinoma: a gynecologic oncology group study. Cancer Treat Rep 63:21–27

    PubMed  CAS  Google Scholar 

  • Thigpen JT, Blessing JA, DiSaia P, Ehrlich C (1985) Treatment of advanced or recurrent endometrial carcinoma with medroxyprogesterone acetate (MPA): a gynecologic oncology group study. Gynecol Oncol 20:250

    Google Scholar 

  • Truskett ID, Constable WC (1968) Management of carcinoma of the corpus uteri. Am J Obstet Gynecol 101:689–694

    Google Scholar 

  • Tseng L, Gusberg S, Gurpide E (1977) Estradiol receptor and 17-beta-dehydrogenase in normal and abnormal human endometrium. Ann NY Acad Sci 286:190–198

    PubMed  CAS  Google Scholar 

  • Varga A, Henriksen E. (1965) Histologic observations on the effect of 17-alpha- hydroxyprogesterone-17-N-caproate on endometrial carcinoma. Obstet Gynecol 26:656–664

    PubMed  CAS  Google Scholar 

  • Vesterinen E, Backas NE, Pesonen K et al. (1981) Effect of medroxyprogesterone acetate on serum levels of LH, FSH, cortisol and estrone in patients with endometrial carcinoma. Arch Gynecol 230:205–211

    PubMed  CAS  Google Scholar 

  • Vihko R, Jänne O, Kauppila A (1980) Steroid receptors in normal hyperplastic and malignant human endometria. Ann Clin Res 12:208–215

    PubMed  CAS  Google Scholar 

  • Vongtama V, Kurohara SS, Badib AO, Webster JH (1970) Second primary cancer of endometrial carcinoma. Cancer 26:842–846

    PubMed  CAS  Google Scholar 

  • Wait RB (1973) Megestrol acetate in the management of advanced endometrial carcinoma. Obstet Gynecol 41:129–136

    PubMed  CAS  Google Scholar 

  • Wentz WB (1964) Effect of a progestational agent on endometrial hyperplasia and endometrial cancer. Obstet Gynecol 24:370–375

    PubMed  CAS  Google Scholar 

  • Wentz WB (1974) Progestin therapy in endometrial hyperplasia. Gynecol Oncol 2:362–367

    PubMed  CAS  Google Scholar 

  • Wharam MD, Phillips TL, Bagshaw MA (1976) Role of radiation therapy in clinical stage I carcinoma of the endometrium. Int J Radiat Oncol Biol Phys 1:1081–1089

    PubMed  CAS  Google Scholar 

  • Wintz H (1941) Ergebnisse der Behandlug von Unterleibkrebsen mit Rontgenstrahlen, Strahlentherapie 69:3

    Google Scholar 

  • Yasizi R, Piver MS, Blumenson L (1983) Malignant peritoneal cytology as prognostic indicator in stage I endometrial cancer. Obstet Gynecol 62:359–362

    Google Scholar 

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Authors and Affiliations

  1. Gynecologic Oncology Department, Cancer Institute (Hospital) Chinese Academy of Medical Sciences, Beijing, 100021, P.R.China

    Dr. Shen-yi Li (Associate Professor, Chief of Medical Affairs Branch) & Dr. En-yu Wang (Associate Professor)

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  1. Dr. Shen-yi Li
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  2. Dr. En-yu Wang
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© 1990 The People’s Medical Publishing House Beijing and Springer-Verlag Berlin Heidelberg

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Li, Sy., Wang, Ey. (1990). Treatment of Endometrial Carcinoma. In: Endometrial Carcinoma. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74821-9_4

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  • DOI: https://doi.org/10.1007/978-3-642-74821-9_4

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  • Print ISBN: 978-3-540-51273-8

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