Diagnosis of Endometrial Carcinoma



Endometrial carcinoma is primarily a disease of postmenopausal women. The peak incidence between 55 and 59 years of age is later than for cervical cancer. Only 2%–5% of all cases are diagnosed before the age of 40 and there is a sharp drop in the incidence after 70 years of age. Only 20%–25% of cases occur in premenopausal women (Silverberg 1975; Mattingly 1985; Aalders et al. 1980; Malkasian et al. 1980).


Obstet Gynecol Fallopian Tube Endometrial Carcinoma Vaginal Bleeding Uterine Cavity 
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  1. Aalders JG, Abeler V, Kolstad P et al. (1980) Post-operative external irradiation and prognostic parameters in stage I endometrial carcinoma: clinical and histopathologic study of 540 patients. Obstet Gynecol 56:419–427PubMedGoogle Scholar
  2. Aalders JG, Abeler V, Kolstad P (1984) Recurrent adenocarcinoma of the endometrium: a clinical and histopathological study of 379 patients. Gynecol Oncol 17:85–103PubMedGoogle Scholar
  3. Alenghat E, Talerman A (1982) Case report adenocarcinoma of the vermiform appendix presenting as a uterine tumor. Gynecol Oncol 13:265–268PubMedGoogle Scholar
  4. Ansah-Boateng Y, Wells M, Poole DR (1985) Coexistent immature teratoma of the uterus and endometrial adenocarcinoma complicated by gliomatosis peritonei. Gynecol Oncol 21:106–110PubMedGoogle Scholar
  5. Anderson B, Louis F, Watring WG, Edinger DD Jr (1980) Growth patterns in endometrial carcinoma. Gynecol Oncol 10:134–145PubMedGoogle Scholar
  6. Axelrod JH, Fruchter R, Boyce JG (1984) Multiple primaries among gynecologic malignancies. Gynecol Oncol 18:359–372PubMedGoogle Scholar
  7. Ayre JE (1955) Rotating endometrial brush: new technic for the diagnosis of fundal carcinoma. Obstet Gynecol 5:137PubMedGoogle Scholar
  8. Ayre SE, Narvaez R (1973) Carcinoma in situ: behavior patterns and cytoimmunology. Oncology 27:294–304PubMedGoogle Scholar
  9. Baggish MS (1980) Evaluation and staging of endometrial and endocervical adenocarcinoma by contact hysteroscopy. Gynecol Oncol 9:182–192PubMedGoogle Scholar
  10. Baggish MS, Barbot J (1983) Contact hysteroscopy. Clin Obstet Gynaecol 26:219–241Google Scholar
  11. Bailar JG III (1963) The incidence of independent tumors among uterine cancer patients. Cancer 16:842–853PubMedGoogle Scholar
  12. Barbaro CA, Fortune DW, Bodey AS et al. (1982) Uterine-lavage in the diagnosis of endometrial malignancy and its precursors. Acta Cytol 26:135–140PubMedGoogle Scholar
  13. Bardot J, Parent B, Dubuisson J (1980) Contact hysteroscopy: another method of endoscopic examination of the uterine cavity. Am J Obstet Gynecol 136:721–726Google Scholar
  14. Beller V, Beckman EM, Twombly GH (1984) Spontaneous regression of advanced endometrial carcinoma. Gynecol Oncol 17:381–385PubMedGoogle Scholar
  15. Berman ML, Barlow SC, Lagasse LD et al. (1980) Prognosis and treatment of endometrial cancer. Am J Obstet Gynecol 136:679–688PubMedGoogle Scholar
  16. Bibbo M, Reale FR, Reale JC et al. (1979) Assessment of three sampling technics to detect endometrial cancer and its precusors. Acta Cytol 23:353–359PubMedGoogle Scholar
  17. Bies JR, Ellis JH, Kopecky KK et al. (1984) Assessment of primary gynecologic malignancies of 0.15T resistive MRI with CT. Am J Roentgenol 143:-1249Google Scholar
  18. Billroth T (1879) Chirurgische Klinik in Wien 1871–1876 mit einem Gesamt-Bericht über die chirurgischen Kliniken in Zürich und Wien während der Jahre 1860–1876 Erfahrungen auf dem Gebiete der praktischen Chirurgie. Hirschwald, Berlin p258Google Scholar
  19. Butler H, Bryan PJ, Lipuma Jr et al. (1984) Magnetic resonance imaging of the abnormal female pelvis. Am J Roentgenol 143:1259–1266Google Scholar
  20. Cahan WG (1977) International workshop on multiple primary cancer. Introductory remarks. Cancer 40:1785Google Scholar
  21. Campbell JS, Magner D, Fournier P (1961) Adenoacanthomas of ovary and uterus occurring as coexistent or sequential primary neoplasms. Cancer 14:817–826PubMedGoogle Scholar
  22. Carenza L, DiGregorio R, Mocci C et al. (1980) Ectopic human chorionic gonadotropin: gynecologic tumors and non-malignant conditions. Gynecol Oncol 10:32–38PubMedGoogle Scholar
  23. Cary WHA (1943) A method of obtaining endometrial smear for study of their cellular content. Am J Obstet Gynecol 46:422–424Google Scholar
  24. Civantos F, Rywlin AD (1972) Carcinomas with trophoblastic differentiation and secretion of chorionic gonadotropins. Cancer 29:789–797PubMedGoogle Scholar
  25. Conference on spontaneous regression of cancer (1966) NCI Monogr:44Google Scholar
  26. Cook GBA (1966) A comparison of single and multiple primary cancers. Cancer 19:959–966PubMedGoogle Scholar
  27. Creasman WT, Boronow RC, Morrow CP et al. (1976) Adenocarcinoma of the endometrium: its metastatic, lymph node potential. Gynecol Oncol 4:239–243PubMedGoogle Scholar
  28. Creasman WT, Weed JC Jr (1981) Carcinoma of endometrium (FIGO Stage I and II): clinical features and management. In: Coppleson M (ed) Gynecologic oncology: fundamental principles and clinical practice. Churchill Livingstone Edinbourgh, 571–577Google Scholar
  29. Czernobilsky B, Silverman BB, Mikuta JJ (1972) Endometrial carcinoma of the ovary. Cancer 26: 1142–1152Google Scholar
  30. Day JC (1958) The second primary malignant tumor in gynecology: review of the literature and series presentation. Am J Obstet Gynecol 75:976–982PubMedGoogle Scholar
  31. Deligdisch L, Szulman EE (1975) Multiple and multifocal carcinomas in female genital organs and breast. Gynecol Oncol 3:181–190PubMedGoogle Scholar
  32. Dockerty MB (1954) Primary and secondary ovarian adenocanthoma. Surg Gynecol Obstet 99: 392PubMedGoogle Scholar
  33. Du Toit JP (1985) Carcinoma of the uterine body. In: Shepherd JH, Monaghan JM (eds) Clinical gynaecological oncology. Blackwell, Oxford, 97–132Google Scholar
  34. Eifel P, Hendrickson M, Ross J et al. (1982) Simultaneous presentation of carcinoma involving the ovary and uterine corpus. Cancer 50:163–170PubMedGoogle Scholar
  35. Everson TC, Cole WH (1966) Spontaneous regression of cancer. Saunders, PhiladelphiaGoogle Scholar
  36. FIGO (1970) Classification and staging of malignant tumors in the female pelvis. Am Coll obstet Gynecol Tech Bull 47:1–4Google Scholar
  37. Fisher MS (1976) Metastasis to the esophagus. Gastrointest Radiol 1:249–251PubMedGoogle Scholar
  38. Fox H, Langley FA (1976) Tumors of the ovary. Heinemann, London, ch 12Google Scholar
  39. Gaulayev B, Sherman Y, Diamant Y (1984) A case of triple primary gynecological malignancy. Gynecol Oncol 18:257–260PubMedGoogle Scholar
  40. Gravlee LC (1969) Jet-irrigation method for the diagnosis of endometrial adenocarcinoma. Obstet Gynecol 34:168PubMedGoogle Scholar
  41. Hricak H, Lacey C, Schrick E et al. (1985) Gynecologic masses: value of magnetic resonance imaging. Am J Obstet gynecol 153:31–37PubMedGoogle Scholar
  42. Joelsson I, Levine RU, Moberger G (1971) Hysteroscopy as an adjunct in determining the extent of carcinoma of the endometrium. Am J Obstet Gynecol 111:696–702PubMedGoogle Scholar
  43. Jones HW (1975) Treatment of adenocarcinoma of the endometrium. Obstet Gynecol Surv 30:147–169PubMedGoogle Scholar
  44. Karlen JR, Sternberg LB, Abbott JN (1972) Carcinoma of the endometrium co-existing Pregnancy. Obstet Gynecol 40:334–339PubMedGoogle Scholar
  45. Kawada CY, An-Foraker SH (1979) Screening for endometrial carcinoma. Clin Obstet Gynecol 22:713–728PubMedGoogle Scholar
  46. Kempson RL, Pokorny GE (1968) Adenocarcinoma of the endometrium in women aged forty and younger. Cancer 21:650–662PubMedGoogle Scholar
  47. Knapp RH, Fritz SR, Reiman HM (1982) Primary embryonal carcinoma and choriocarcinoma of the mediastinum. Arch Pathol Lab Med 106:507–509PubMedGoogle Scholar
  48. Koss LG, Schreiber K, Moussouris M et al. (1982) Endometrial carcinoma and its precursors: detection and screening. Clin Obstet Gynecol 25:49–61PubMedGoogle Scholar
  49. Kottmeier HL (1953) Carcinoma of the female genitalia. Williams and Wilkins, BaltimoreGoogle Scholar
  50. Kurman RJ, Craig JM (1972) Endometrioid and clear cell carcinoma of the ovary. Cancer 29: 1653–1664PubMedGoogle Scholar
  51. Lang JH, Wu BZ, Tang MY (1978) Endometrial carcinoma, a clinico-pathologic analysis of 108 cases, J Chin Obstet Gynecol 13:6–12Google Scholar
  52. Latrop JC, Wachtel TJ, Meissner CF (1978) Uterine choriocarcinoma fourteen years following bilateral tubal ligation. Obstet Gynecol 51:477–482Google Scholar
  53. Lawrence DW (1984) Gynecologic pathology specialty conference. International Academy of Pathology, San FranciscoGoogle Scholar
  54. Lewis BV, Stallworthy JA, Cordell R (1970) Adenocarcinoma of the body of the uterus. J Obstet Gynecol Br Commonw 77:343–348Google Scholar
  55. Linden M, Roger V (1982) Diagnosis of endometrial carcinoma using the Mi-Mark(R) Helix Sampling Technique. Acta Obstet Gynecol Scand 61:227PubMedGoogle Scholar
  56. Lindermann HJ (1972) The use of C02 in the uterine cavity for hysteroscopy. Int J Fertil 7221–224Google Scholar
  57. Lindemann HJ (1974) CO2 hysteroscopy, diagnosis and treatment. In: Phillips JM, Keith L (eds) Gynecological laparoscopy. Symposia specialists, Miami, p 299Google Scholar
  58. Li SY (1988) Prognosis of endometrial carcinoma. In: Li SY (ed) Endometrial carcinoma. People’s Medical Publishing House, Beijing, 169–189Google Scholar
  59. MacMahon B, Austin JH (1969) Association of carcinoma of the breast and corpus uteri. Cancer 23:275–280PubMedGoogle Scholar
  60. Malkasian GD, Annegers JF, Fountain KS (1980) Carcinoma of the endometrium: stage I. Am J Obstet Gynecol 136:872–888PubMedGoogle Scholar
  61. Marinaccio L, Mazzarella L (1967) Gravindansa con parto a termine in soggetto affetto da adenoacanthoma dell ‘endometrio’. Cancro (Italy) 20:582–601Google Scholar
  62. Matlock DL, Salem FA, Charles EH, Savage EW (1982) Synchronous multiple neoplasms of the upper female genital tract. Gynecol Oncol 13:271–277PubMedGoogle Scholar
  63. Mattingly RF (1985) Malignant tumors of the uterus. In: Mattingly RF, Thompson JD (eds) Telinde’s operative gynecology, 6th edn. Lippincott, Philadelphia, 845–876Google Scholar
  64. McKechnie C, Fechner RE (1971) Choriocarcinoma and adenocarcinoma of the esophagus with gonadotropin secretion. Cancer 27:694–702PubMedGoogle Scholar
  65. Moertel CG, Dockerty MB, Baggenstass AH (1961) Multiple primary malignant neoplasms. II. Tumors of different tissue or organs. Cancer 14:231–237PubMedGoogle Scholar
  66. Mold JW (1969) Benign solid teratoma of uterus. J Pathol 99:173–175PubMedGoogle Scholar
  67. Morris M, Noumoff J, Beckman EM, Bigelow B (1985) Endometrial carcinoma presenting with ascites. Gynecol Oncol 21:186–195PubMedGoogle Scholar
  68. Munnell EW, Taylor HC (1949) Ovarian carcinoma. Am J Obstet Gynecol 58:943–959PubMedGoogle Scholar
  69. Musumeci R, DePalo G, Couti V et al. (1980) Are retroperitoneal lymph node metastases a major problem in endometrial adenocarcinoma? Cancer 46:1887–1892PubMedGoogle Scholar
  70. Nicholson GW (1956) Studies on tumor formation. XXI. A polypoid teratoma of the uterus. Guy’s Hosp Rep 105:157–189Google Scholar
  71. Obe JA, Rosen N, Koss LG (1983) Primary choriocarcinoma of the urinary bladder: report of a case with probable epithelial origin. Cancer 52:1405–1409PubMedGoogle Scholar
  72. Pacifico E, Miraglia M, Miraglia F (1982) Diagnosis of endometrial carcinoma and its precusors by means of cytologic examination of jet-washing material. Acta Cytol 26:630–632PubMedGoogle Scholar
  73. Park CH, Reid JD (1980) Adenocarcinoma of the colon with choriocarcinoma in its metastasis. Cancer 46:570–575PubMedGoogle Scholar
  74. Pyrah RD, Redman TF (1968) Teratoma of the uterus with an associated congenital anomaly. J Pathol Bacteriol 95:291–295PubMedGoogle Scholar
  75. Requard CK, Wicks JD, Mettler FA Jr (1981) Ultrasonography in the staging of endometrial adenocarcinoma. Radiology 140:781–785PubMedGoogle Scholar
  76. Richard RM, Barron BAA (1969) Follow-up study of cervical dysplasia. Am J Obstet Gynecol 105:386–393Google Scholar
  77. Rutledge FN (1974) The role of radical hysterectomy in adenocarcinoma of the endometrium. Gynecol Oncol 2:331–347PubMedGoogle Scholar
  78. Saigo PE, Rosen PP (1981) Mammary carcinoma with “choriocarcinomatous” features. Am J Surg Pathol 5:773–778PubMedGoogle Scholar
  79. Saigo PE, Rosen PP, Brigati DJ et al. (1981) Primary gastric choriocarcinoma: an immunohistological study. Am J Surg Pathol 5:333–342PubMedGoogle Scholar
  80. Sandstrom RE, Welch WR, Green TH Jr (1978) Adenocarcinoma of the endometrium in pregnancy. Obstet Gynecol 53:73S–76SGoogle Scholar
  81. Savage J, Subby W, Okagaki T (1987) Adenocarcinoma of the endometrium with trophoblastic differentiation and metastases as choriocarcinoma: a case report. Gynecol Oncol 26:257–262PubMedGoogle Scholar
  82. Schoenberg BS, Greenberg RA, Eisenberg H (1969) Occurrence of certain multiple primary cancer in females. JNCI 43:15–32PubMedGoogle Scholar
  83. Schoenberg BS (1977) Multiple primary malignant neoplasms: the Connecticut experience 1935–1964. Springer, Vienna New YorkGoogle Scholar
  84. Schottenfeld D, Berg J (1971) Incidence of multiple primary cancer. IV. Cancer of the female breast and genital organs. JNCI 46:161–170PubMedGoogle Scholar
  85. Schueller EF, Kirol PM (1966) Prognosis in endometrial carcinoma of the ovary. Obstet Gynecol 27:850–858PubMedGoogle Scholar
  86. Schumann EA (1927) Observation upon the coexistence of carcinoma fundus uteri and pregnancy. Trans Amer Gynecol Soc 52:245–256Google Scholar
  87. Schwartz Z, Ohel G, Birkenfeld A et al. (1985) Second primary malignancy in endometrial carcinoma patients. Gynecol Oncol 22:40–45PubMedGoogle Scholar
  88. Scully RE, Richardson GS, Barlow JF (1966) The development of malignancy in endometriosis. Clin Obstet Gynecol 9:384–411PubMedGoogle Scholar
  89. Sedagal E, Iversen OE (1983) Endoscann, a new endometrial cell sampler. Br J Obstet Gynaecol 90:266–271Google Scholar
  90. Silverberg E (1975) Gynecologic cancer: statistical and epidemiological information. American Cancer SocietyGoogle Scholar
  91. Sugimoto O (1975) Hysteroscopic diagnosis of endometrial carcinoma. Am J Obstet Gynecol 121:105–113PubMedGoogle Scholar
  92. Sugimoto O (1981) Diagnostic hysteroscopy in gynecologic oncology. In: Coppleson M, (ed) Fundamental principles and clinical practice. Churchill Livingstone, Edinbourgh p 229–239Google Scholar
  93. Surwit EA, Fowler WC Jr, Rogoff EE (1978) Stage II carcinoma of the endometrium: an analysis of treatment. Obstet Gynecol 52:97–99PubMedGoogle Scholar
  94. Suzuki A, Konishi I, Okamura H, Nanashima N (1984) Adenocarcinoma of the endometrium associated with intrauterine pregnancy. Gynecol Oncol 18:261–269PubMedGoogle Scholar
  95. Tak WK, Anderson B, Vardi JR et al. (1977) Myometrial invasion and hysterography in endometrial carcinoma. Obstet Gynecol 50:159–165PubMedGoogle Scholar
  96. Thickman I, Kressel H, Gussman D et al. (1984) Nuclear magnetic resonance imaging in gynecology. Am J Roentgenol 141:835–840Google Scholar
  97. Tyagi SP, Saxena K, Rivi R, Langley FA (1979) Foetal remnants in the uterus and their relation to other uterine heterotopia. Histopathology 3:339PubMedGoogle Scholar
  98. Valle RF, Sciarra JJ (1979) Current status of hysteroscopy in gynecologic practice. Fertil Steril 32:619–632PubMedGoogle Scholar
  99. Vongtama V, Kurohara SS, Badib AO, Webster JH (1970) Second primary cancers of endometrial carcinoma. Cancer 26:842–846PubMedGoogle Scholar
  100. Wall JA, Lucci JA Jr (1953) Adenocarcinoma of the corpus uteri and pelvic tuberculosis complicating pregnancy. Obstet Gynecol 2:629–635PubMedGoogle Scholar
  101. Wallin TE, Malkasian GD, Gaffey TA et al. (1984) Stage II cancer of the endometrium: pathologic and clinical study. Gynecol Oncol 18:1–17PubMedGoogle Scholar
  102. Wallingford AJ (1934) Cancer of the body of the uterus complicating pregnancy. Amer J Obstet Gynecol 27:224–231Google Scholar
  103. Walsh JW, Brewer WH, Schneider V (1980) Ultrasound diagnosis in diseases of the uterine corpus and cervix. Semin Ultrasound 1:30–40Google Scholar
  104. Warren S, Gates O (1932) Multiple primary tumors: a survey of the literature and a statistical study. Am J Cancer 16:1358–1414Google Scholar
  105. Westmann AA (1934) Case of simultaneous pregnancy and cancer of the corpus uteri. Acta Obstet Gynecol Scand 14:191–194Google Scholar
  106. White AJ, Buchsbaum HJ, Rodman NF (1973) Accuracy of the Gravlee Jet washer in detecting endometrial adenocarcinoma. Am J Obstet Gynecol 116:1169–1170PubMedGoogle Scholar
  107. White TGEA (1955) Chorion-epithelioma of the uterus in a postmenopausal woman. J Obstet Gynecol Br Emp 62:372Google Scholar
  108. Wurzel J, Brooks JJ (1981) Primary gastric choriocarcinoma. Cancer 48:2756–2761PubMedGoogle Scholar
  109. Wu BZ, Tang MY, Lang JH (1982) Endometrial carcinoma. In: Lin QZ (ed) Gynecologic oncology. People’s Medical Publishing House, Beijing, 85–104Google Scholar
  110. Zarian LP, Berliner L, Redmond P (1983) Metastatic endometrial carcinoma to the esophagus. Am J Gastroenterol 78:9–11PubMedGoogle Scholar

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© The People’s Medical Publishing House Beijing and Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  1. 1.Gynecologic Oncology DepartmentCancer Institute (Hospital) Chinese Academy of Medical SciencesBeijingP.R.China

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