Abstract
The prognosis of localized osteosarcoma of the extremities (LOE) treated by surgery alone is very poor. In our experience, in spite of amputation, the disease-free survival rate for these patients is only 10%. This percentage seems unchanged in the last 20 years, at least at the Rizzoli Institute (Table 1).
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References
Rosen G, Marcove RC, Caparros B et al. (1979) Primary osteogenic sarcoma: the rationale for preoperative chemotherapy and delayed surgery. Cancer 43:2163–2177
Morgan E, Baum E, Bleyer WA et al. (1984) Treatment of patients with metastatic osteogenic sarcoma: a report from the Children’s Cancer Study Group. Cancer Treat Rep 68:661–664
Crom WR, Pratt CB, Gree AA et al. (1984) The effect of prior cisplatin therapy on the pharmakinetics of high-dose methotrexate. J Clin Oncol 6:655–661
Gasparini M, Fossati-Bellani F, Rottoli L et al. (1983) Remission induction by chemotherapy (VCR, HDMTX, CDP) in osteosarcoma. Proc ASCO 2:239
Bacci G, Springfield DS, Capanna R et al. (1987) Neoadjuvant chemotherapy for osteosarcoma of the extremity. Clin Orthop 221:268–276
Jaffe N, Knapp J, Chuang W et al. (1983) Osteosarcoma: intra-arterial treatment of the primary tumor with cisdiammine-dichloroplatinum (CDP). Cancer 51:402–408
Benjamin RS, Chawla SP, Carrasco CH et al. (1987) Primary chemotherapy of patients with osteosarcoma of an extremity. Proc ASCO 6:139
Krailo M, Ertel I, Makley J et al. (1987) A randomized study comparing high dose methotrexate with moderate dose methotrexate as component of adjuvant chemotherapy in childhood nonmetastatic osteosarcoma: a report from the Children’s Cancer Study Group. Med Pediatr Oncol 15:69–77
Bacci G, Gherlinzoni F, Picci P et al. (1986) adriamycin-methotrexate high dose versus adriamycin-methotrexate moderate dose as adjuvant chemotherapy for osteosarcoma of the extremities: a randomized study. Eur J Cancer Clin Oncol 22:1337–1344
Winkler K, Beron G, Kotz R et al. (1984) Neoadjuvant chemotherapy for osteosarcoma: results of a cooperative German/Austrian study. J Clin Oncol 2:617–624
Winkler K, Beron G, Delling G et al. (1988) Neoadjuvant chemotherapy of osteosarcoma: results of a randomized cooperative trial (COSS-82) with salvage chemotherapy based on histological tumor response. J Clin Oncol 6:329–337
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© 1990 Springer-Verlag Berlin Heidelberg
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Bacci, G. et al. (1990). Neo-adjuvant Chemotherapy for Osteosarcoma of the Extremities: The Experience at the Rizzoli Institute in 210 Patients Treated with Two Successively Activated Preoperative Protocols Using High-Dose or Moderate-Dose Methotrexate + Cisplatin or High-Dose Methotrexate + Cisplatin + Doxorubicin. In: Jakesz, R., Rainer, H. (eds) Progress in Regional Cancer Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74818-9_28
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DOI: https://doi.org/10.1007/978-3-642-74818-9_28
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