Diminished Corticosterone Levels in Nude Mice Implanted with MCF-7 or ZR-75-1 Human Breast Tumor Cells
Corticosteroid levels were studied in the plasma of athymic mice implanted with human breast tumor cells, either from MCF-7 or ZR-75-1 cell lines. There was a highly significant decrease in plasma corticosterone levels in the mice implanted with these tumor cells. There was no significant effect on corticosterone of GW 39 colon cancer cells, LS 174 T colon cancer cells, or Calu-3 lung cancer cells.
There have been multiple studies of Cortisol levels in women with breast cancer. Both significant [1, 2] and non-significant [3, 4] increases have been reported. However, the cause of the fluctuations is unknown. They might be due to the tumor, or they might reflect the anxiety of preoperative. Indeed, in one report, postoperative patients had normal plasma cortisol levels .
We have studied corticosteroids in athymic mice bearing human breast tumors derived from MCF-7 or ZR-75-1, two well established human breast cancer cell lines [6, 7].
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