Bombesin and Gastrin-Releasing Peptide: Neuropeptides, Secretogogues, and Growth Factors

  • A.-M. Lebacq-Verheyden
  • J. Trepel
  • E. A. Sausville
  • J. F. Battey
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 95 / 2)


In the early 1960s, V. Erspamer and colleagues observed that crude methanol extracts of amphibian skin exerted a wide range of pharmacological actions on vascular and extravascular smooth muscle, on external and internal secretions, and on renal circulation and function. This observation prompted the isolation of numerous bioactive peptides that were remarkably abundant in amphibian skin. The knowledge gained from their structure and function often helped to identify homologous peptides in mammalian tissues, where they existed only in minute amounts. Structurally related peptides had the same pharmacological profile and were grouped into families. The major families included the tachykinins, the caeruleins, and the bombesins (Erspamer and Melchiorri 1973). Peptides of these families were originally identified as digestive hormones and as central modulators of metabolism and behavior; more recently, they became also known as growth factors. The present review deals with bombesin and with its mammalian homolog, the gastrin-releasing peptide (GRP).


Ethylene Glycol Tetraacetic Acid Ethylene Glycol Tetraacetic Acid Gastrin Release Peptide Small Cell Lung Cancer Cell Amylase Release 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • A.-M. Lebacq-Verheyden
  • J. Trepel
  • E. A. Sausville
  • J. F. Battey

There are no affiliations available

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