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Relationships Between Oncogenes and Growth Control

  • A. Leutz
  • T. Graf
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 95 / 2)

Abstract

In recent years we have witnessed a revolution in the understanding of the mechanisms which regulate mammalian cell growth. This applies both to normal cells, in which growth is tightly controlled, as well as to cancer cells, which divide in an uncontrolled fashion. With the advent of molecular biology a number of genes have been identified whose products are involved in regulating normal cell growth. In parallel research 40–60 genes that are capable of inducing a transformed phenotype and that have been termed “on-cogenes” have been identified. It is now clear that growth control genes on the one hand and oncogenes on the other are largely one and the same. Although unequivocal evidence for this notion was obtained only recently, the concept itself emerged gradually beginning with the discovery of viral oncogenes (v-onc genes) and the fact that these genes represent cell-derived sequences (termed protooncogenes, cellular oncogenes, or c-onc genes).

Keywords

Mouse Mammary Tumor Virus Avian Sarcoma Virus Epidermal Growth Factor Recep Simian Sarcoma Virus Avian Erythroblastosis Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • A. Leutz
  • T. Graf

There are no affiliations available

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