• M. Klagsbrun
  • J. Folkman
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 95 / 2)


“Angiogenesis” is currently used to describe the growth of new capillary blood vessels by sprouting from established vessels to produce “neovascularization.” “Vasculogenesis” denotes the development of blood vessels in the embryo (Risau and Lemmon 1988; Feinberg and Beebe 1983). There is as yet no adequate term to describe the growth of larger vessels such as coronary artery collaterals where actual proliferation of vascular endothelium and smooth muscle lead to enlargement of the lumenal diameter (Schaper 1981; Pasyk et al. 1982; D’amore and Thompson 1987). Nor is there a description of endothelial proliferation in the capillaries of hypertrophic heart muscle in the apparent absence of sprouting (Hudlicka and Tyler 1986). However, the term “non- sprouting angiogenesis” is useful (Folkman 1987).


Mast Cell Fibroblast Growth Factor Angiogenic Factor Basic Fibroblast Growth Factor Capillary Endothelial Cell 
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© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • M. Klagsbrun
  • J. Folkman

There are no affiliations available

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