Inflammation and Repair

  • H. L. Wong
  • S. M. Wahl
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 95 / 2)


Injuries to tissue, whether due to mechanical, chemical, immunological, or thermal insults, initiate an orderly but complex series of cellular and biochemical interactions that lead to the formation of new tissue and the eventual repair of the wound. The cellular components of this pathway include hematopoietic cells such as platelets, polymorphonuclear leukocytes, lymphocytes, and monocytes, and mesenchymal cells such as fibroblasts and endothelial cells. These cells migrate to the site of tissue damage in a sequence determined by soluble factors that are released at the site of injury through a wide variety of mechanisms. Among these are tissue breakdown, blood coagulation, and cellular release. Each cell type has a specific function to perform such as degradation and resorption of damaged tissue, protection against infection, or deposition of new extracellular matrix.


Arachidonic Acid Metabolite Hepatic Granuloma Streptococcal Cell Wall Fibroblast Population Cell BioI 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • H. L. Wong
  • S. M. Wahl

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