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Extracellular Matrices, Cells, and Growth Factors

  • G. R. Martin
  • A. C. Sank
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 95 / 2)

Abstract

The importance of cell-matrix interactions in development has been long recognized. The major functions of the matrix are to provide physical support to the tissues and to maintain cellular viability. Stability and homeostasis are achieved in this way. Extracellular matrices are structurally diverse but they vary in a tissue-specific fashion. Thus cartilage, tendon, bone, basement membranes, etc., contain different matrix proteins optimized for their individual functions and for their particular cells. Current concepts indicate that cells form a continuum with their matrix (Hay 1981), having specific receptors that bind to the various proteins that comprise the matrix. These contacts are instructive for the cells and influence their migration, morphology, growth, and differentiation. Such receptors also permit the cells to monitor the composition of the matrix and allow an autocrine regulation of matrix production.

Keywords

Basement Membrane Phorbol Ester Matrix Molecule Extracellular Matrice Laminin Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Angel P, Baumann I, Stein B, Delius H, Rahmsdorf HJ, Herrlich P (1987 a) 12-O-Tetra decanoyl-phorbol-13-acetate (TPA) induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5’ flanking region. Mol Cell Biol 7: 2256–2266PubMedGoogle Scholar
  2. Angel P, Imagawa M, Chiu R, Stein B, Inbra RJ, Rahmsdorf HJ, Jonat C, Herrlich P, Karin MB (1987 b) Phorbol ester-inducible genes contain a common cis element recognized by a TPA modulated trans-acting factor. Cell 49: 729–739PubMedCrossRefGoogle Scholar
  3. Aumailley M, Timpl R (1986) Attachment of cells to basement membrane collagen type IV. J Cell Biol 103: 1569–1575PubMedCrossRefGoogle Scholar
  4. Aumailley M, Nurcombe V, Edgar D, Paulsson M, Timpl R (1987) The cellular interactions of laminin fragments. Cell adhesion correlates with two fragment-specific high affinity binding sites. J Biol Chem 262:11 532–11 538Google Scholar
  5. Bauer EA, Cooper TW, Huang JS, Altman J, Deuel TF (1985) Stimulation of in vitro human skin collagenase expression by platelet-derived growth factor. Proc Natl Acad Sci USA 82: 4132–136PubMedCrossRefGoogle Scholar
  6. Bell E, Ivarsson B, Merrill C (1979) Production of a tissue-like structure by contracture of collagen lattices by human fibroblasts of different proliferative potential in vitro. Proc Natl Acad Sci USA 76: 1274–1278PubMedCrossRefGoogle Scholar
  7. Bitterman PB, Rennard SI, Adelberg S, Crystal RG (1983) Role of fibronectin as a growth factor for fibroblasts. J Cell Biol 97: 1925–1932PubMedCrossRefGoogle Scholar
  8. Brinckerhoff CE, Plucrnska M, Sheldon ZA, O’Connor GT (1986) Half-life of synovial cell collagenase mRNA is modulated by phorbol myristic acetate but not by all- transretmoic acid or dexamethasone. Biochemistry 25: 6378–6384PubMedCrossRefGoogle Scholar
  9. Charonis AS, Skubitz APN, Koliakos GG, Reger L, Dege J, Vogel AM, Wohlueter R, Furcht LT (1988) A novel synthetic peptide of the B1 chain of laminin with heparin- binding and cell-adhesion promoting activities. J Cell Biol 107: 1253–1260PubMedCrossRefGoogle Scholar
  10. Chiu R, Boyle WJ, Meek J, Smeal T, Hunter T, Karin M (1988) The C-fos protein interacts with c-y’jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell 54: 541–552PubMedCrossRefGoogle Scholar
  11. Chua CC, Geiman DE, Keller GH, Ladda RL (1985) Induction of collagenase secretion in human fibroblast cultures by growth promoting factors. J Biol Chem 260: 5213–5216PubMedGoogle Scholar
  12. Dedhar S, Ruoslahti E, Pierschbacher MD (1987) A cell surface receptor complex for collagen type I recognizes the Arg-Gly-Asp sequence. J Cell Biol 104: 585–592PubMedCrossRefGoogle Scholar
  13. De Petro G, Barlali S, Vartio T, Vaheri A (1981) Transformation-enhancing activity of gelatin-binding fragments of fibronectin. Proc Natl Acad Sci USA 78: 4965–4969PubMedCrossRefGoogle Scholar
  14. Dike LE, Farmer SR (1988) Cell adhesion induces expression of growth-associated genes in suspension-arrested fibroblasts. Proc Natl Acad Sei USA 85: 6792–6796CrossRefGoogle Scholar
  15. Edgar D, Timpl R, Thoenen H (1984) The heparin-binding domain of laminin is responsible for its effects on neunte out growth and neuronal survival. EMBO J 3: 1463–1468PubMedGoogle Scholar
  16. Edwards DR, Murphy G, Reynolds JJ, Whitham SE, Docherty AJB, Angel P, Heath JK (1987) Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor. EMBO J 6: 1899–1904PubMedGoogle Scholar
  17. Ehrlich HP (1988) The role of connective tissue matrix in wound and fracture healing. In: Barbul A, Pines E, Caldwell M, Hunt TK (eds) Growth factors and other aspects of wound healing. Liss, New York, pp 243–258Google Scholar
  18. Evered D, Whelan J (eds) (1986) Function of the proteoglycans. Ciba Found Symp 124Google Scholar
  19. Gehlsen KR, Dillmer L, Engvall E, Ruoslahti E (1988) The human laminin receptor. Science 241: 1228–1229Google Scholar
  20. Goldberg B (1979) Binding of soluble type I collagen molecules to the fibroblast plasma membrane. Cell 16: 265–275PubMedCrossRefGoogle Scholar
  21. Goldberg Gl, Wilhelm SM, Kronberger A, Bauer EA, Grant GA, Eisen AZ (1986) Human fibroblast collagenase. Complete primary structure and homology to an oncogeny transformation-induced rat protein. J Biol Chem 261. 6600–6605Google Scholar
  22. Goodman SL, Deutzmann R, von der Mark K (1987) Two distinct cell binding domains in laminin can independently promote non-neuronal cell adhesion and spreading. J Cell Biol 105: 589–598PubMedCrossRefGoogle Scholar
  23. Gospodarowicz D, Greenburg G, Birdwell CR (1978) Determination of cell shape by the extracellular matrix and its correlation with the control of cellular growth. Cancer Res 38: 4155–4171PubMedGoogle Scholar
  24. Graf J, Iwamoto Y, Sasaki M, Martin GR, Kleinman HK, Robey FA, Yamada Y (1987) Identification of an amino acid sequence in laminin mediating cell attachment, Chemotaxis and receptor binding. Cell 48: 989–996PubMedCrossRefGoogle Scholar
  25. Gross J (1981) An essay on the biological degradation of collagen. In: Hay ED (ed) Cell biology of extracellular matrix. Plenum, New York, pp 217–258CrossRefGoogle Scholar
  26. Grotendorst GR, Martin GR (1986) Chemotaxis in wound healing and fibrosis. Rheumatol Annu 10: 385–103Google Scholar
  27. Hasseil JR, Kimura JH, Hascall VC (1986) Proteoglycan core protein families. Annu Rev Biochem 55: 539–568CrossRefGoogle Scholar
  28. Hay ED (1981) Collagen and embryonic development. In: Hay ED (ed) Cell biology of extracellular matrix. Plenum, New York, pp 379–409CrossRefGoogle Scholar
  29. Herbst TJ, McCarthy JB, Tsilibary EC, Furcht LT (1988) Differential effects of laminin, intact type IV collagen and specific domains of type IV collagen on endothelial cell adhesion and migration. J Cell Biol 106: 1365–1373PubMedCrossRefGoogle Scholar
  30. Humphries J J, Akujama SK, Komoriya A, Olden K, Yamada KM (1986) Identification of an alternatively spliced site in human plasma fibronectin that mediates cell type specific adhesion. J Cell Biol 103: 2637–2647PubMedCrossRefGoogle Scholar
  31. Humphries MJ, Ayad SR (1983) Stimulation of DNA synthesis by cathepsin D digests of fibronectin. Nature 305: 811–813PubMedCrossRefGoogle Scholar
  32. Hynes RO (1987) Integrins: a family of cell surface receptors. Cell 48: 549–554PubMedCrossRefGoogle Scholar
  33. Kleinman HK, Klebe RJ, Martin GR (1981) Role of collagenous matrices in the adhesion and growth of cells. J Cell Biol 88: 473–85PubMedCrossRefGoogle Scholar
  34. Kleinman HK, McGarvey ML, Hassell JR, Martin GR (1983) Formation of a supramolecular complex is involved in the reconstitution of basement membrane components. Biochemistry 22: 4969–4974PubMedCrossRefGoogle Scholar
  35. Kleinman HK, Cannon FB, Laurie G, Hassell JR, Aumailley M, Terranova VP, Martin GR, Dubois-Dalcq M (1985) Biological activities of laminin. J Cell Biochem 27: 317–325PubMedCrossRefGoogle Scholar
  36. Kleinman HK, McGarvey ML, Hassell JR, Star VL, Cannon FB, Laune GW, Martin GR (1986) Basement membrane complexes with biological activity. Biochemistry 25: 312–318PubMedCrossRefGoogle Scholar
  37. Krane SM, Amento EP, Goldberg MB, Goldring SR, Stephenson ML (1988) Modulation of matrix synthesis and degradation in joint inflammation. In: Glauert EL (ed) The control of tissue damage. Elsevier, Amsterdam, pp 179–195Google Scholar
  38. Kubota Y, Kleinman HK, Martin GR, Lawley TJ (1988) Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures. J Cell Biol 107: 1589–1598PubMedCrossRefGoogle Scholar
  39. Liotta LA, Abe S, Gehron-Robey P, Martin GR (1979) Preferential digestion of a basement membrane collagen by an enzyme derived from a metastatic murine tumor. Proc Natl Acad Sei USA 76: 2268–2272CrossRefGoogle Scholar
  40. Martin GR, Timpl R (1987) Laminin and other basement membrane components. Annu Rev Cell Biol 3: 57–87PubMedCrossRefGoogle Scholar
  41. Martin GR, Kleinman HK, Terranova VP, Ledbetter S, Hasseil JR (1984) The regulation of basement membrane formation and cell-matrix interactions by defined supramolecular complexes. Ciba Found Symp 108: 197–212PubMedGoogle Scholar
  42. Martin GR, Timpl R, Muller PK, Kuhn K (1985) The genetically distinct collagens. Trends Biochem Sei 10: 285–287CrossRefGoogle Scholar
  43. Mauck C, van der Mark K, Helle O, Mollenhauer J, Paffle M, Krieg T (1988) A defective cell surface collagen-binding protein in dermatosparatic sheet fibroblasts. J Cell Biol 106: 205–211CrossRefGoogle Scholar
  44. Mayne R, Burgeson RE (1987) Structure and function of collagen types. Academic, New YorkGoogle Scholar
  45. McCarthy JB, Furcht LT (1984) Laminin and fibronectin promote the haeptotactic migration of B16 mouse melanoma cells in vitro. J Cell Biol 98: 1474–1480PubMedCrossRefGoogle Scholar
  46. Moscatelli D, Rifkin DB (1988) Membrane and matrix localization of proteinases: a common theme in tumor cell invasion and angiogenesis. Biochim Biophys Acta 948: 67–85PubMedGoogle Scholar
  47. Murphy G, Cockett MI, Stephens PE, Smith BJ, Docherty AJP (1987) Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes. Biochem J 248: 265–268Google Scholar
  48. Nishizuka Y (1986) Protein kinases in signal transduction. In: Bradshaw RA, Printes S (eds) Oncogenes and growth factors. Elsevier, Amsterdam, pp 248–254Google Scholar
  49. Nusgens B, Merrill C, Lapiere C, Bell E (1984) Collagen biosynthesis by cells in a tissue equivalent matrix in vitro. Coll Relat Res 4: 351–364PubMedGoogle Scholar
  50. Obara M, Kang MS, Yamada KM (1988) Site directed mutagenesis of the cell binding domain of human fibronectin: separable, synergistic sites mediate adhesive function. Cell 53: 649–657PubMedCrossRefGoogle Scholar
  51. Panayotou G, End P, Aumailley M, Timpl R, Engel J (1989) Domains of laminin with growth-factor activity. Cell 56: 93–101PubMedCrossRefGoogle Scholar
  52. Polla BS, Healy AM, Byrne M, Krane SM (1987) 1,25-Dihydroxyvitamin D3 induces collagen binding to the human monocyte line A937. J Clin Invest 80: 962–969Google Scholar
  53. Rhudy RW, McPherson JM (1988) Influence of the extracellular matrix on the proliferative response of human skin fibroblasts to serum and purified platelet- derived growth factor. J Cell Physiol 137: 185–191PubMedCrossRefGoogle Scholar
  54. Rubin K, Hook M, Obrink B, Timpl R (1981) Substrate adhesion of rat hepatocytes: mechanism of attachment to collagen substrates. Cell 24: 463–470PubMedCrossRefGoogle Scholar
  55. Ruoslahti E (1988 a) Fibronectin and its receptors. Annu Rev Biochem 57:375–413Google Scholar
  56. Ruoslahti E (1988 b) Structure and biology of proteoglycans. Annu Rev Cell Biol 4:229–255Google Scholar
  57. Salomon DS, Liotta LA, Kidwell WR (1981) Differential response to growth factor by rat mammary epithelium plated on different collagen substrata in serum-free medium. Proc Natl Acad Sci USA 78: 382–386PubMedCrossRefGoogle Scholar
  58. Sarber R, Hull B, Merrill C, Soranno T, Bell E (1981) Regulation of proliferation of fibroblasts of low and high population doubling levels grown in collagen lattices. Mech Ageing Dev 17: 107–117PubMedCrossRefGoogle Scholar
  59. Sasaki M, Kleinman HK, Huber H, Deutzmann R, Yamada Y (1988) Laminin, a multidomain protein: the A chain has a unique globular domain and homology with the basement membrane proteoglycan and the laminin B chains. J Biol Chem 263: 16536–16544PubMedGoogle Scholar
  60. Schonthal A, Herrlich P, Rahmsdorf HJ, Ponta H (1988) Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbolesters. Cell 54: 325–334PubMedCrossRefGoogle Scholar
  61. Sporn MB, Roberts AB (1986) Peptide growth factors and inflammation, tissue repair and cancer. J Clin Invest 78: 329–332PubMedCrossRefGoogle Scholar
  62. Takada Y, Wayner EA, Carter WG, Hemmler ME (1988) Extracellular matrix receptors, ECMRII and ECMRI, for collagen and fibronectin correspond to VLA-2 and VLA-3 with VLA family of heterodimers. J Cell Biochem 37: 385–393PubMedCrossRefGoogle Scholar
  63. Terracio L, Ronnstrand L, Tingstrom A, Rubin K, Claesson-Welsh L, Funa K, Heldin C (1988) Induction of platelet-derived growth factor receptor expression in smooth muscle cells and fibroblasts upon tissue culturing. J Cell Biol 107: 1947–1957PubMedCrossRefGoogle Scholar
  64. Terranova VP, Aumailley M, Sultan LH, Martin GR, Kleinman HK (1986) Regulation of cell attachment and growth by fibronectin and laminin. J Cell Physiol 27: 473–479CrossRefGoogle Scholar
  65. Timpl R, Dziadek M (1986) Structures, development and molecular pathology of basement membranes. Int Rev Exp Pathol 29: 1–112PubMedGoogle Scholar
  66. Tomaselli JJ, Damsky CH, Reichardt LF (1988) Purification and characterization of mammalian integrins expressed by a rat neuronal cell line (PCI2): evidence that they function as a ß heterodimeric receptors for laminin and type IV collagen. J Cell Biol 107: 1241–1251PubMedCrossRefGoogle Scholar
  67. Turpeenniemi-Hujanen T, Thorgeirsson UP, Rao CN, Liotta LA (1986) Laminin increase the release of type IV collagenase. J Biol Chem 261: 1883–1889PubMedGoogle Scholar
  68. Van Evercooren A, Kleinman HK, Ohno S, Marangos P, Schwartz JP, Dubois-Dalcq ME (1982) Nerve growth factor, laminin and fibronectin promote neurite growth in human fetal sensory ganglia cultures. J Neurosci Res 8: 179–194CrossRefGoogle Scholar
  69. Verma IM (1986) Proto-oncogene fos: a multifaceted gene. In: Bradshaw RA, Prentes S (eds) Oncogenes and growth factors. Elsevier, Amsterdam, pp 67–73Google Scholar
  70. Vlodavsky I, Folkman J, Sullivan R, Fridman R, Michaeli I, Sasse J, Klagsbrun M (1987) Endothelial cell derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix. Proc Natl Acad Sci USA 84: 2292–2296PubMedCrossRefGoogle Scholar
  71. Weinberg CB, Bell E (1985) Regulation of proliferation of bovine endothelial cells, smooth muscle cells and adventitial fibroblasts in collagen lattices. J Cell Physiol 122: 410–414PubMedCrossRefGoogle Scholar
  72. Yamada KM (1983) Cell surface interactions with extracellular materials. Annu Rev Biochem 52: 761–799PubMedCrossRefGoogle Scholar
  73. Yoshizato K, Taira T, Shioya N (1986) Collagen dependent growth suppression and changes in the shape of human dermal fibroblasts. Ann Plast Surg 13: 9–14CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • G. R. Martin
  • A. C. Sank

There are no affiliations available

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