Coordinate Actions of Hematopoietic Growth Factors in Stimulation of Bone Marrow Function

  • M. A. S. Moore
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 95 / 2)


The proliferation and differentiation of bone marrow stem cell populations requires a balance between the need to meet the production of mature myeloid cells and the necessity of ensuring the retention of a population of self-renewing stem cells. This requires that the stem cell pool is protected from exhaustion by excessive differentiation pressure, providing a constant pool or reserve of stem cells throughout life. A number of models have been provided to explain this phenomenon. The stochastic model of Till and McCulloch (1980) envisages hematopoiesis engendered randomly (HER), whereas the deterministic model of Trentin (1970) envisaged the role of a hematopoietic inductive microenvironment (HIM). The current status of understanding of stem cell regulation requires a compromise between these two extreme views, in which stochastic events occur with a probability that can be modulated by external influences — a “loaded dice” concept. It is in this latter respect that hematopoietic growth factors may play a critical role.


Mast Cell Aplastic Anemia Coordinate Action Bone Marrow Culture Hematopoietic Growth Factor 
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© Springer-Verlag Berlin Heidelberg 1990

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  • M. A. S. Moore

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