Pentapeptide Growth Inhibitors

  • W. R. Paukovits
  • K. Elgjo
  • O. D. Laerum
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 95 / 2)


The hemoregulatory peptide and the epidermal pentapeptide are small oligopeptides (molecular weight around 500–600) involved in the regulation of proliferation in their respective tissues in vitro and in vivo. The identification of these peptides was achieved after a 20–year-long search for specific endogenous feedback inhibitors of proliferation initiated by P. Weiss and Kavanau (1957), Bullough and Laurence (1960), and Iversen (1960). Both peptides function in a similar way in their respective tissues. They probably originate from differentiated (mature) cells, i. e. polymorphonuclear neutrophil (PMN) granulocytes or mature keratinocytes, respectively, and they reduce the proliferative activity in their progenitor cells (stem cells, myeloid progenitors, or epidermal basal cells). They are similar (Fig. 1) in chemical structure, suggesting a larger family of regulatory peptides of which the hemoregulatory peptide and the epidermal pentapeptide are the first known members.


Mitotic Rate Hairless Mouse Skin Extract Mouse Epidermal Cell Epidermal Basal Cell 
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© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • W. R. Paukovits
  • K. Elgjo
  • O. D. Laerum

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