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Osteopenie bei Ratten mit arzneimittelbedingter Mucopolysaccharidose

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Neuere Ergebnisse in der Osteologie

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Summary

Tilorone, a drug with immunostimulatory activities, interferes with the lysosomal degradation of sulfated glycosaminoglycans (sGAG) in rats and causes osteopenia reminiscent of that occuring in patients with inherited mucopolysaccharidosis (MPS). While osteopenia in such patients is thought to result from impaired enchondral ossification, in rats it appears to be due to accelerated resorption of the primary spongiosa.

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Author information

Authors and Affiliations

  1. Anatomisches Institut, Universität Kiel, Olshausenstr. 40, 2300, Kiel, Germany

    A. Peters

Authors
  1. A. Peters
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Editor information

Editors and Affiliations

  1. Orthopädische Klinik und Poliklinik, Georg-August-Universität, Robert-Koch-Straße 40, D-3400, Göttingen, Deutschland

    Hans-Georg Willert

  2. Radiologisches Institut, Zentrum Radiologie Katharinen-Hospital, Akad. Lehrkrankenhaus Universität Tübingen, Kriegsbergstraße 60, D-7000, Stuttgart 1, Deutschland

    Friedrich H. W. Heuck (Ärztl. Direktor i.R.) (Ärztl. Direktor i.R.)

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© 1989 Springer-Verlag · Heidelberg

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Peters, A. (1989). Osteopenie bei Ratten mit arzneimittelbedingter Mucopolysaccharidose. In: Willert, HG., Heuck, F.H.W. (eds) Neuere Ergebnisse in der Osteologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74770-0_41

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  • DOI: https://doi.org/10.1007/978-3-642-74770-0_41

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-51175-5

  • Online ISBN: 978-3-642-74770-0

  • eBook Packages: Springer Book Archive

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