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Ruthenium and Other Non-Platinum Metal Complexes in Cancer Chemotherapy pp 89–109Cite as

Metal Complexes as Radiosensitizers

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Part of the book series: Progress in Clinical Biochemistry and Medicine ((PCBM,volume 10))

Abstract

Many classes of transition metal complexes enhance cellular radiation damage both in vitro and in vivo. The radiosensitization of hypoxic cells is of clinical relevance due to the inherent radioresistance of a tumor hypoxic fraction. Selective attack on hypoxic cells may also be achieved by development of hypoxic cytotoxins and chemosensitizers, which may act by enhancing the hypoxic toxicity of other agents. In radiosensitization three principal mechanisms by which metal complexes act are by DNA-binding with subsequent consequences to repair processes, thiol depletion, and by an electron-affmic mechanism, implying reduction of the metal complex and subsequent fixation of damage on the intracellular target of radiation, DNA. The types of complexes shown to act by the above mechanisms are summarized.

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Author information

Authors and Affiliations

  1. Department of Chemistry, University of Vermont, Burlington, VT, 05405, USA

    Nicholas Farrell

Authors
  1. Nicholas Farrell
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Editor information

Editors and Affiliations

  1. Département de Chimie Biologique, Faculté de Médecine de Bicêtre, Université de Paris Sud, Hôpital de Bicêtre, F-94270, Bicêtre, France

    Etienne Baulieu

  2. Department of Pathology, School of Medicine, University of North Carolina, Chapel Hill, NC, 27514, USA

    Donald T. Forman

  3. Karolinska Institutet Institutionen för Medicinsk Kemi, Box 60400, S-104 01, Stockholm, Sweden

    Magnus Ingelman-Sundberg

  4. Institut für Biochemie, Universität Köln, An der Bottmühle 2, D-5000, Köln, Germany

    Lothar Jaenicke

  5. Sunnybrook Medical Centre, University of Toronto, 2075 Bayview Avenue, M4N 3M5, Toronto, Ontario, Canada

    John A. Kellen

  6. Department of Biochemistry Faculty of Medicine, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan

    Yoshitaka Nagai

  7. Immunochemistry Research, Evanston Hospital, Northwestern University, 2650 Ridge Avenue, 60201, Evanston, IL, USA

    Georg F. Springer

  8. Klinikum der Johann Wolfgang Goethe-Universität, Gustav-Embden-Zentrum, Theodor Stern Kai 7, D-6000, Frankfurt a. M. 70, Germany

    Lothar Träger

  9. Zentralinstitut für Herz- und Kreislauf-Forschung, Akademie der Wissenschaften der DDR, Lindenberger Weg 70, DDR-1115, Berlin-Buch, Germany

    Liane Will-Shahab

  10. Hormone Receptor Laboratory, James Graham Brown Cancer Center, University of Louisville, 40292, Louisville, KY, USA

    James L. Wittliff

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© 1989 Springer-Verlag Berlin Heidelberg

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Farrell, N. (1989). Metal Complexes as Radiosensitizers. In: Baulieu, E., et al. Ruthenium and Other Non-Platinum Metal Complexes in Cancer Chemotherapy. Progress in Clinical Biochemistry and Medicine, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74760-1_5

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  • DOI: https://doi.org/10.1007/978-3-642-74760-1_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74762-5

  • Online ISBN: 978-3-642-74760-1

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