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Karyotypic Analysis of Solid Tumors

  • Chapter
Pathology of the Nucleus

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 82))

Abstract

Much progress has been made in and much published on the chromosome changes and their significance in cancer and leukemia during the last decade. This progress has included not only the cytogenetic definition and classification of various leukemias (Rowley 1984; Sandberg 1986 a), but also the cytogenetic “dissection” of some solid tumor entities (Sandberg and Turc-Carel 1987; Sandberg et al. 1988) and the application of the karyotypic findings to molecular approaches (Croce 1986; Duesberg 1987). The latter have uncovered rearrangements of genes (including oncogenes) in some conditions, increased or abnormal gene expression in others, and the need for more knowledge regarding the exact genes affected in most human neoplastic states.

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Authors
  1. P. Dal Cin
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  2. A. A. Sandberg
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Editors and Affiliations

  1. Department of Pathology, University of Sheffield Medical School, Beech Hill Road, S10 2RX, Sheffield, UK

    James C. E. Underwood Professor, M.D., F.R.C. Path.

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© 1990 Springer-Verlag Berlin Heidelberg

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Dal Cin, P., Sandberg, A.A. (1990). Karyotypic Analysis of Solid Tumors. In: Underwood, J.C.E. (eds) Pathology of the Nucleus. Current Topics in Pathology, vol 82. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74668-0_6

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  • DOI: https://doi.org/10.1007/978-3-642-74668-0_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74670-3

  • Online ISBN: 978-3-642-74668-0

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