Barrett’s Oesophagus

  • F. Potet
  • V. Duchatelle
Part of the Current Topics in Pathology book series (CT PATHOLOGY, volume 81)


Barrett’s oesophagus or columnar epithelial lined lower oesophagus (CELLO) is usually considered to be an acquired disorder complicating prolonged reflux oesophagitis. In 1953, Allison and Johnstone described hiatal hernia with oesophageal stricture, below which the oesophagus was lined with gastric epithelium. In 1957, Barret described the columnar-lined oesophagus and its complications such as ulcer, stricture and carcinoma. At the same time, Lortat-Jacob et al. (1957) described this entity under the term “endobrachyoesophage”. CELLO consists of several types of columnar epithelium, one of which is the very distinctive “specialised columnar type”. The latter resembles intestinal metaplasia (IM) of the stomach. Barrett’s oesophagus is a condition of considerable interest because several authors have reported a high incidence of adenocarcinoma arising in CELLO.


Columnar Epithelium Oesophageal Adenocarcinoma Mucin Histochemistry Pancreatic Gastrinoma Fluorescent Lectin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Allsion, Johnstone AS (1953) The esophagus lined with gastric mucous membrane. Thorax 8:87–101CrossRefGoogle Scholar
  2. Barrett NR (1957) The lower esophagus lined by columnar epithelium. Surgery 41:881–895PubMedGoogle Scholar
  3. Belladonna JA, Hajdu SI, Bains MS (1974) Adenocarcinoma in situ of Barrett’s esophagus diagnosed by endoscopic cytology. N Engl J Med 291:895–896PubMedCrossRefGoogle Scholar
  4. Berenson MM, Herbst JJ, Freston JW (1974) Enzyme and ultrastructural characteristics of esophageal columnar epithelium. Am J Dig Dis 19:895–907PubMedCrossRefGoogle Scholar
  5. Berenson MM, Riddell RH, Skinner DB, Freston JW (1978) Malignant transformation of esophageal columnar epithelium. Cancer 41:554–561PubMedCrossRefGoogle Scholar
  6. Bozymski EM, Herlihy KJ, Orlando RC (1982) Barrett’s esophagus. Ann Intern Med 97:103–107PubMedGoogle Scholar
  7. Buchan AMJ, Grant S, Freeman HJ (1985) Regulatory peptides in Barrett’s oesophagus. J Pathol 146:227–234PubMedCrossRefGoogle Scholar
  8. Cameron AJ, Ott BJ, Payne WS (1985) The incidence of adenocarcinoma in columnar lined (Barrett’s) esophagus. N Engl J Med 313:857–859PubMedCrossRefGoogle Scholar
  9. Garewal HS, Sampliner R, Gerner E, Steinbronn K, Alberts D, Kendall D (1988) Ornithine decarboxylase activity in Barrett’s esophagus: a potential marker for dysplasia. Gastroenterolgy 94, 819–821Google Scholar
  10. Haggitt RC, Dean PJ (1985) Adenocarcinoma in Barrett’s epithelium. In: Spechler SJ, Goyal RK (eds) Barrett’s esophagus, Elsevier, New York, pp 153–166Google Scholar
  11. Haggitt RC, Tryzelaar J, Ellis FM, Colcher H (1978) Adenocarcinoma complicating columnar epithelium lined (Barrett’s) esophagus. Am J Clin Pathol 70:1–5PubMedGoogle Scholar
  12. Haggitt RH, Reid BJ, Rabinovitch PS, Rubin CE (1988) Barrett’s Esophagus. Correlation between mucin histochemistry, flow cytometry and histologic diagnosis for predicting increased cancer risk. Am J Pathol 131,53–61PubMedGoogle Scholar
  13. Hameeteman W, Tytgat GNJ, Houthoff HJ, Van Den Tweel JG (1989) Barrett’s esophagus: development of dysplasia and adenocarcinoma. Gastroenterology 96,1249–1256PubMedGoogle Scholar
  14. Hamilton SR, Smith RRL (1987) The relationship between columnar epithelial dysplasia and invasive adenocarcinoma arising in Barrett’s esophagus. Am J Clin Pathol 87:301–312PubMedGoogle Scholar
  15. Hamilton SR, Yardley JA (1977) Regeneration of cardia type mucosa and acquisition of Barrett mucosa after esophagogastrostomy. Gastroenterology 72:669–675PubMedGoogle Scholar
  16. Hamilton SR, Hutcheon DF, Ravich WJ, Paulson M (1984) Adenocarcinoma of Barrett’s esophagus after elimination of gastroesophageal reflux. Gastroenterology 86:356–360PubMedGoogle Scholar
  17. Herbst JJ, Berenson MM, McGloskey DW, Wise WC (1978) Cell proliferation in esophageal columnar epithelium (Barrett’s esophagus). Gastroenterology 75:683–687PubMedGoogle Scholar
  18. Herlihy KJ, Orlando RC, Bryson JC, Bozymski EM, Carney CN, Powell DW (1984) Barrett’s esophagus: clinical, endoscopic, histologic, manometric and electrical potential difference characteristics. Gastroenterology 86:436–443PubMedGoogle Scholar
  19. Jass JR (1981) Mucin histochemistry of the columnar epithelium of oesophagus: a retrospective study. J Clin Pathol 34:866–870PubMedCrossRefGoogle Scholar
  20. Kalish RJ, Clancy PE, Orringer MB, Appelman HD (1984) Clinical, epidemiologic, and morphologic comparison between adenocarcinomas arising in Barrett’s esophagus and in the gastric cardia. Gastroenterology 86:461–467PubMedGoogle Scholar
  21. Lee RG (1984): Mucins in Barrett’s esophagus: a histochemical study. Am J Clin Pathol 81:500–503Google Scholar
  22. Lee RG (1985): Dysplasia in Barrett’s esophagus: a clinical pathologic study of six patients. Am J Surg Pathol 9, 845–852Google Scholar
  23. Lee RG (1986) Adenomas arising in Barrett’s esophagus. Am J Clin Pathol, 85:629–632PubMedGoogle Scholar
  24. Lortat-Jacob JL (1957) L’endobrachyoesophage. Ann Chir 11:1247–1254Google Scholar
  25. Ma J, Deboer W, Nayman J (1982) Intestinal mucinous substances in gastric intestinal metaplasia and carcinoma studied by immunofluorescence. Cancer 49, 1664–1667PubMedCrossRefGoogle Scholar
  26. McDonald GB, Brand DL, Thorning DR (1977) Multiple adenomatous neoplasms arising in columnar lined (Barrett’s) esophagus. Gastroenterology 72:1317–1321PubMedGoogle Scholar
  27. Naef AP, Savary M, Ozello L (1975) Columnar lined lower esophagus: an acquired lesion with malignant predispositon: report on 140 cases of Barrett’s esophagus with 12 adenocarcinomas. J Thorac Cardiovasc Surg 70:826–835PubMedGoogle Scholar
  28. Pascal RR, Clearfield HR (1987): Mucoepidermoid (adenosquamous) carcinoma arising in Barrett’s esophagus. Dig Dis Sci 32:428–432Google Scholar
  29. Paull A, Trier JS, Dalton MO, Camp RC, Loeb P, Goyal RK (1976): The histological spectrum of Barrett’s esophagus. N Engl J Med 295:476–480Google Scholar
  30. Pellish LJ, Hermos JA, Eastwood GL (1980) Cell proliferation in three types of Barrett’s epithelium. Gut 21, 26–31PubMedCrossRefGoogle Scholar
  31. Peuchmaur M, Potet F, Goldfain D (1984) Mucin histochemistry of the columnar epithelium of the oesophagus (Barrett’s oesophagus): a prospective study. J Clin Pathol 37:607–610PubMedCrossRefGoogle Scholar
  32. Pope CE (1985) Regression of Barrett’s epithelium. In Spechler SJ, Goyal RK (eds), Barrett’s esophagus, Elsevier, New York, pp 224–229Google Scholar
  33. Reid BJ, Haggitt RC, Rubin CE, Rabinovitch PS (1987) Barrett’s esophagus. Correlation between flow cytometry and histology in detection of patients at risk for adenocarcinoma. Gastroenterology 93, 1–11PubMedGoogle Scholar
  34. Reid BJ, Weinstein WM, Lewin KJ, Haggitt RC, VanDeventer G, DenBesten L, Rubin CE (1988) Endoscopic biopsy can detect high-grade dysplasia or early adenocarcinoma in Barrett’s esophagus without grossly recognizable neoplastic lesions. Gastroenterology 94, 81–90PubMedGoogle Scholar
  35. Riddell RH (1985) Dysplasia and regression in Barrett’s epithelium. In Barrett’s esophagus, Spechler SJ, Goyal RK (eds) Barrett’s esophagus, Elsevier, New York, pp 143–152Google Scholar
  36. Rosenberg JC, Budev H, Edwards RC, Singal S, Steiger Z, Sunderson AS (1985) Analysis of adenocarcinoma in Barrett’s esophagus utilizing a staging system. Cancer 55:1353–1360PubMedCrossRefGoogle Scholar
  37. Rothery GA, Patterson JE, Stoddard CJ, Day DW (1986) Histological and histochemical changes in the columnar lined (Barrett’s) oesophagus. Gut 27:1062–1068PubMedCrossRefGoogle Scholar
  38. Sanfey H, Hamilton SR, Smith RRL, Cameron JL (1985) Carcinoma arising in Barrett’s esophagus. Surg Gynecol Obstet 161:570–574PubMedGoogle Scholar
  39. Saubier EC, Gouillat C, Samaniego C, Guillaud M, Moulinier B (1985) Adenocarcinoma in columnar lined Barrett’s esophagus. Analysis of 13 esophagectomies. Am J Surg 150:365–369PubMedCrossRefGoogle Scholar
  40. Schmidt HG, Riddell RH, Walther B, Skinner DB, Riemann JF (1985) Dysplasia in Barrett’s esophagus. J Cancer Res Clin Oncol 110, 145–152PubMedCrossRefGoogle Scholar
  41. Shimamoto C, Weinstein WW, Boland CR (1985) Glyconjugate (GC) expression in metaplastic and dysplastic epithelium in Barrett’s esophagus (BE). Gastroenterology 88, 1632 (abstr)Google Scholar
  42. Sjøgren RW Jr, Johnson LF (1983) Barrett’s esophagus: a review. Am J Med 74:313–321PubMedCrossRefGoogle Scholar
  43. Skinner DB, Walther BC, Riddell RH, Schmidt H, Iascone C, De MeesterTR (1983) Barrett’s esophagus: comparison of benign and malignant cases. Ann Surg 198:554–566PubMedCrossRefGoogle Scholar
  44. Smith RRL, Hamilton SR, Boitnott JK, Rogers EI (1984) The spectrum of carcinoma arising in Barrett’s esophagus: a clinicopathologic study of 26 patients. Am J Surg Pathol 8:563–573PubMedCrossRefGoogle Scholar
  45. Sontag SJ, Schnell TG, Chejfec G, O’Connell S, Stanley MM, Best W, Chintam R, Nemchausky B, Wanner J, Moroni B (1985) Barrett’s oesophagus and colonic tumours Lancet 1:946–949PubMedCrossRefGoogle Scholar
  46. Spechler SJ, Goyal RK (1986) Barrett’s esophagus. N Engl J Med 315:362–371PubMedCrossRefGoogle Scholar
  47. Spechler SJ, Robbins AH, Rubins HB, Vincent ME, Heeren T, Doos WG, Colton T, Schimmel EM (1984) Adenocarcinoma and Barrett’s esophagus: an overrated risk? Gastroenterology 87:927–933PubMedGoogle Scholar
  48. Sprung DJ, Ellis FH, Gibb SP (1984) Incidence of adenocarcinoma in Barrett’s esophagus. Am J Gastroenterol 79, 817 (abstr)Google Scholar
  49. Steinbronn K, Alberts D, Gerner E (1987) Ornithine decarboxylase levels in Barrett’s esophagus: correlation with dysplasia. Gastroenterology 92, 1400 (abstr)Google Scholar
  50. Symonds DA, Ramsey ME (1980) Adenocarcinoma arising in Barrett’s esophagus with Zollinger syndrome. Am J Clin Pathol 73:823–826PubMedGoogle Scholar
  51. Thompson JJ, Zinsser KR, Enterline HT (1983) Barrett’s metaplasia and adenocarcinoma of the esophagus and the gastroesophageal junction. Hum Pathol 14:42–61PubMedCrossRefGoogle Scholar
  52. Trier JS (1985) Morphology of the columnar cell-lined. (Barrett’s) esophagus. In: Spechler SJ Goyal RK (eds) Barrett’s esophagus, Elsevier, New YorkGoogle Scholar
  53. Van der Veen AH, Dees J, Blankensteijn JD, Van Blankenstein M (1989) Adenocarcinoma in Barrett’s oesophagus: an overrated risk. Gut 30, 14–18PubMedCrossRefGoogle Scholar
  54. Wang HH, Antonioli DA, Goldman H (1986) Comparative features of esophageal and gastric adenocarcinomas: recent changes in type and frequency. Hum Pathol 17:482–487PubMedCrossRefGoogle Scholar
  55. Winters C, Spurling TJ, Chobanian SJ, Curtis DJ, Esposito RL, Hacker JF, Johnson DA, Cruess DF, Cotelingam JD, Gurney MS, Cattau EL (1987) Barrett’s esophagus. A prevalent, occult complication of gastroesophageal reflux disease. Gastroenterology 92:118–124PubMedGoogle Scholar
  56. Witt TR, Bains MS, Zaman MB, Martini N (1983) Adenocarcinoma in Barrett’s esophagus. J Thorac Cardiovasc Surg 85, 337–345PubMedGoogle Scholar
  57. Zwas F, Shields HM, Doos WG, Antonioli DA, Goldman H, Ransil BJ, Spechler SJ (1986) Scanning electron microscopy of Barrett’s epithelium and its correlation with light microscopy and mucin stains. Gastroenterology 90:1932–1941PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • F. Potet
  • V. Duchatelle

There are no affiliations available

Personalised recommendations