Summary
Twenty-two leukemias, 11 of which were undifferentiated with respect to surface antigen markers, were investigated for their antigen receptor gene rearrangement, transcription products of these antigen receptor genes, and surface antigen pattern of the cells. Among the three less-differentiated groups rearrangement was observed in 2/10 cases for the TCR ß-chain and in 4/11 cases for the heavy-chain gene. TCR ß-mRNA, however, was expressed in seven out of eight cases and the μ heavy-chain mRNA in eight out of ten cases investigated. Also mRNA of TCR α, the rearrangement of which could not be detected with our probes, was expressed as frequently as TCR ß. Although rearrangement of the appropriate gene was found regularly in the more mature leukemias, transcription of these genes was lower or even lacking. These findings indicate that expression of antigen receptor mRNA in undifferentiated leukemias can be activated by events other than maturational rearrangement.
This work was supported by the Deutsche Forschungsgemeinschaft grant Em 60/1–2.
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© 1990 Springer-Verlag Berlin Heidelberg
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Volkmann, M., Mar, P., Pachmann, K., Thiel, E., Emmerich, B. (1990). Antigen Receptor Rearrangement and Expression in Acute Leukemias. In: Büchner, T., Schellong, G., Hiddemann, W., Ritter, J. (eds) Acute Leukemias II. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74643-7_8
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DOI: https://doi.org/10.1007/978-3-642-74643-7_8
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