Skip to main content

Minimal Residual Disease in Acute Leukemia:Lessons Learned from Animal Models

  • Conference paper
Acute Leukemias II

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 33))

  • 155 Accesses

Abstract

Minimal residual disease (MRD) in acute leukemia is defined as the relatively few (1 – 1010) leukemic cells which have survived successful remission-induction chemotherapy. In human acute myelocytic leukemia (AML) there is a significant lack of knowledge on the degree and biological behavior of MRD. However, this is the population of AML cells that determines the failure in the majority of patients:a relapse.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Hagenbeek A, Van Bekkum DW (eds) (1977) Proceedings of an international workshop on Comparative evaluation of the L5222 and the BNML rat leukaemia models and their relevance for human acute leukaemia. Leuk Res 1:75–256

    Google Scholar 

  2. Hagenbeek A, Martens ACM (1985) Detection of minimal residual disease in acute leukemia:possibilities and limitations. Eur J Cancer Clin Oncol 21:389–394

    Article  PubMed  CAS  Google Scholar 

  3. Martens ACM, Hagenbeek A (1985) Detection of minimal disease in acute leukemia using flow cytometry:studies in a rat model for human acute leukemia. Cytometry 6:342–347

    Article  PubMed  CAS  Google Scholar 

  4. Martens ACM, Johnson RJ, Kaizer H, Hagenbeek A (1984) Characteristics of a monoclonal antibody (Rml24) against acute myelocytic leukemia cells. Exp Hematol 12:667–672

    PubMed  CAS  Google Scholar 

  5. Martens ACM, Schultz FW, Hagenbeek A (1987) Nonhomogeneous distribution of leukemia in the bone marrow during minimal residual disease. Blood 70:1073–1077

    PubMed  CAS  Google Scholar 

  6. Van Bekkum DW, Hagenbeek A (1977) Relevance of the BN leukemia as a model for human acute myeloid leukemia. Blood Cells 3:565–572

    Google Scholar 

  7. Visser JWM, Martens ACM, Hagenbeek A (1986) Detection of minimal residual disease in acute leukemia by flow cytometry. Ann NY Acad Sci 468:268–276

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Hagenbeek, A., Martens, A.C.M. (1990). Minimal Residual Disease in Acute Leukemia:Lessons Learned from Animal Models. In: Büchner, T., Schellong, G., Hiddemann, W., Ritter, J. (eds) Acute Leukemias II. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74643-7_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-74643-7_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50984-4

  • Online ISBN: 978-3-642-74643-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics