Acute Monocytic Leukemia with Translocation t(1;11) (p31;q23):Simultaneous Staining of Chromosomes and Cell Surface Antigens

  • I. Nölle
  • B. Schlegelberger
  • N. Schmitz
  • S. Bödewadt-Radzun
  • W. Grote
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 33)


Leukemia is thought to be the clonal expansion of a single mutated cell. Depending on the differentiation stage of this cell, different cell lineages might be involved in tumorigenesis. Keinänen et al. [2] have shown that myeloid, erythrocytic, and megakaryocytic lineages were involved in 8 out of 12 cases of acute myeloid leukemia with monosomy 7 or trisomy 8. In order to evaluate the lineage involvement in a case of acute monocytic leukemia with trisomy 8 and a translocation t(1;11), we modified a method described by Teerenhovi et al. [1]. With this method it is possible to analyze cell surface antigens and chromosomes of the same cell, whereas by standard chromosome preparation the cell membrane and cytoplasmic structures are destroyed.


Acute Myeloid Leukemia Acute Lymphoblastic Leukemia Acute Leukemia Polycythemia Vera Reciprocal Translocation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • I. Nölle
    • 1
  • B. Schlegelberger
    • 1
  • N. Schmitz
    • 2
  • S. Bödewadt-Radzun
    • 3
  • W. Grote
    • 1
  1. 1.Dept. of Human GeneticsUniversity, KielGermany
  2. 2.Dept. of Internal MedicineUniversity, KielGermany
  3. 3.Department of PathologyUniversity, KielGermany

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