Karyotype of Leukemia Cells Consistently Predicts for Response to Therapy and Survival Following Salvage Therapy in Acute Myeloblastic Leukemia

  • M. J. Keating
  • H. Kantarjian
  • E. Estey
  • W. Plunkett
  • J. Trujillo
  • K. B. McCredie
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 33)


Following the introduction of anthracyclines and cytosine arabinoside (Ara-C) into clinical practice in the late 1960s, response rates of 50%–80% in previously untreated patients with acute myeloblasts leukemia (AML) have been obtained [1, 2]. Despite a variety of postremission treatments the remission duration remains 12–15 months, with 20%–25% of patients staying in long-term disease-free state and possibly being cured [3, 4]. One-third of the patients who failed to achieve an initial complete remission do so because of persistence of leukemia cells [5], and 75%–80% of patients who achieve a remission have recurrence of leukemia [3, 4]. Both of these patient populations are eligible for salvage therapy.


Acute Leukemia Salvage Therapy Cytosine Arabinoside Acute Myeloblastic Leukemia Remission Duration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • M. J. Keating
    • 1
  • H. Kantarjian
    • 1
  • E. Estey
    • 1
  • W. Plunkett
    • 1
  • J. Trujillo
    • 1
  • K. B. McCredie
    • 1
  1. 1.Departments of Hematology and Pharmacology, Division of Medicine, and Laboratory MedicineUniversity of Texas, M.D. Anderson Cancer CenterHoustonUSA

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