Experimental and Clinical Studies of Hyperthermia for Carcinoma of the Esophagus

  • K. Sugimachi
  • H. Matsuda
Part of the Clinical Thermology book series (CLIN THERM)


The application of hyperthermia to treat malignant tumors is not a new concept. To Hippocrates (470–377 B.C.), the “Father of Medicine”, is attributed the statement that “Those who cannot be cured by medicine can be cured by surgery. Those who cannot be cured by surgery can be cured by hyperthermia. Those who cannot be cured by hyperthermia are probably incurable.”


Esophageal Cancer Esophageal Carcinoma Adjacent Normal Tissue Ehrlich Ascites Tumor Heat Sensitivity 
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  1. 1.
    Kai H, Matsufuji H, Sugimachi K, Okudaira Y, Inokuchi K (1986) Combined effects of hyperthermia, bleomycin and X-rays on Ehrlich ascites tumor. J Surg Res 41:503–509PubMedCrossRefGoogle Scholar
  2. 2.
    Matsuoka H, Sugimachi K, Mori M, Kuwano H, Ohno S, Nakano S (1989) Effects of hyperthermochemoradiotherapy on KSE-1 cells, a newly established human squamous cell line derived from esophageal carcinoma. Eur Surg Res 2:49–59CrossRefGoogle Scholar
  3. 3.
    Crue G (1963) The effects of heat and radiation on cancers implanted on the feet of mice. Cancer Res 23:372–380Google Scholar
  4. 4.
    Hahn GM (1979) Potential for therapy of drugs and hyperthermia. Cancer Res 39:2264–2268PubMedGoogle Scholar
  5. 5.
    Suit HD, Gerweck LE (1979) Potential for hyperthermia and radiation therapy. Cancer Res 39:2290–2298PubMedGoogle Scholar
  6. 6.
    Ben-Hur E, Elkind MM, Bronk BV (1974) Thermally enhanced radioresponse of cultured Chinese hamster cells. Radiat Res 58:38–51PubMedCrossRefGoogle Scholar
  7. 7.
    Stewart FA, Denekamp J (1978) The therapeutic advantage of combined heat and X rays on a mouse fibrosarcoma. Br J Radiol 51:307–316PubMedCrossRefGoogle Scholar
  8. 8.
    Overgaad J (1980) Simultaneous and sequential hyperthermia and radiation treatment of an experimental tumor and its surrounding tissue in vivo. Int J Radiat Oncol Biol Phys 6:1507–1517Google Scholar
  9. 9.
    Marmor JB, Kozak D, Hahn GM (1979) Effects of systemi-cally administered bleomycin or adriamycin with local hyperthermia on primary tumor and lung metastases. Cancer Treat Rep 63:1279–1290PubMedGoogle Scholar
  10. 10.
    Leith JT, Miller RC, Gerner EW, Boone LM (1977) Hyperthermic potentiation — biological aspects and applications to radiation therapy. Cancer 39:766–779PubMedCrossRefGoogle Scholar
  11. 11.
    Braun J, Hahn GM (1975) Enhanced cell killing by bleomycin and 43°C hyperthermia and the inhibition of recovery from potentially lethal damage. Cancer Res 35:2921–2927PubMedGoogle Scholar
  12. 12.
    Matsuoka H, Sugimchi K, Ueo H, Kuwano H, Nakano S, Nakayama M (1987) Sex hormone response of a newly established squamous cell line derived from clinical esophageal carcinoma. Cancer Res 47:4134–4140PubMedGoogle Scholar
  13. 13.
    Thomlinson RH, Gray LH (1955) The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer 9:539–549PubMedCrossRefGoogle Scholar
  14. 14.
    Manning MR, Cetas TC, Miller RC, Oleason JR, Connor WG, Gerner EW (1982) Clinical hyperthermia — results of a phase 1 trial employing hyperthermia alone or in combination with external beam or interstitial radiotherapy. Cancer 49:205–216PubMedCrossRefGoogle Scholar
  15. 15.
    Sugimachi K, Inokuchi K, Kai H, Kuwano H, Matsuzaki K, Okudaira Y (1983) Hyperthermo-chemo-radiotherapy for carcinoma of the esophagus. Jpn J Surg 13:101–105PubMedCrossRefGoogle Scholar
  16. 16.
    Hand JW (1987) Heat delivery and thermometry in clinical hyperthermia. In: Streffer C (ed) Recent results in cancer research. Springer, Berlin Heidelberg New York, pp 1–23Google Scholar
  17. 17.
    Dickson JA, Shah SA (1977) Technology for the hyperthermic treatment of large solid tumors at 50°C. Clin Oncol 3:301–318PubMedGoogle Scholar
  18. 18.
    Kim JH, Hahn EW, Tokita N, Nisce LZ (1977) Local tumor hyperthermia in combination with radiation therapy. Cancer 40:161–169PubMedCrossRefGoogle Scholar
  19. 19.
    Leveen H, Wapnic S, Piccone V, Falk G, Ahmed N (1976) Tumor eradication by radiofrequency therapy. Response in 21 patients. JAMA 235:2198–2200PubMedCrossRefGoogle Scholar
  20. 20.
    Marmor JB, Pounds D, Hahn GM (1987) Clinical trial of ultrasound induced hyperthermia. Proc 14th annual Meeting of the American Society of Clinical Oncology 19, p 330Google Scholar
  21. 21.
    Stehlin JS, Giovanella BC, Ipolyi PD, Muenz LR, Anderson RF (1975) Results of hyperthermic perfusion for melanoma of the extremities. Surg Gynecol Obstet 140:339–348PubMedGoogle Scholar
  22. 22.
    Qui SL, Li DJ, Shao LF, Wang CQ (1982) A pathological study on intraluminal microwave hyperthermia in esophageal cancer. NCI Monogr 61:415–417Google Scholar
  23. 23.
    Sugimachi K, Inokuchi K, Kai H, Sogawa A, Kawai Y (1983) Endotract antenna for application of hyperthermia to malignant lesions. Gann 74: 622–624PubMedGoogle Scholar
  24. 24.
    Sugaar S, Leveen HH (1979) A histopathologic study on the effects of radiofrequency thermotherapy on malignant tumors of the lung. Cancer 43:767–783PubMedCrossRefGoogle Scholar
  25. 25.
    Sugimachi K, Kai H, Matsufuji H, Ueo H, Inokuchi K (1986) Histopathological evaluation of hyperthermo-chemo-radiotherapy for carcinoma of the esophagus. J Surg Oncol 32:82–85PubMedCrossRefGoogle Scholar
  26. 26.
    Japanese Society of Esophageal Diseases (1976) Guidelines for the clinical and pathological studies for carcinoma of the esophagus. Jpn J Surg 6:79–86CrossRefGoogle Scholar
  27. 27.
    Sugimachi K, Yaita A, Ueo H, Natsuda Y, Inokuchi K (1980) A safer and more reliable operative technique for esophageal reconstruction using a gastric tube. Am J Surg 140:471–474PubMedCrossRefGoogle Scholar
  28. 28.
    Sugimachi K, Matsufuji H, Kai H, Matsuda H, Ueo H, Inokuchi K, Jingu K (1986) Preoperative irradiation for carcinoma of the esophagus. Surg Gynecol Obstet 162: 174–176PubMedGoogle Scholar
  29. 29.
    Koyama Y (1981) I-Hexylcarbamoyl-5-fluorouracil (HCFU) masked 5-fluorinated pyrimidine. Cancer Treat Rev 8:147–156PubMedCrossRefGoogle Scholar
  30. 30.
    Iizuka T, Endo M, Sasaki K, Karasawa K, Kakegawa T, Arimori M, Sasaki T (1980) Preliminary report on multidisciplinary treatment for esophageal carcinoma. Jpn J Clin Oncol 10:215–220Google Scholar
  31. 31.
    Mondovi B, Strom R, Rotilio G, Finazzi Agro A, Cavaliele R, Rossi Fanelli A (1969) The biochemical mechanism of selective heat sensitivity of cancer cells — I. Studies on cellular respiration. Eur J Cancer 5:129–136PubMedCrossRefGoogle Scholar
  32. 32.
    Mondovi B, Finazzi Agro A, Rotilio G, Strom R, Moricca G, Rossi Fanelli A (1969) The biochemical mechanism of selective heat sensitivity of cancer cells — II. Studies on nucleic acids and protein synthesis. Eur J Cancer 5:137–146PubMedCrossRefGoogle Scholar
  33. 33.
    Chen TT, Heidelberger C (1969) Quantitative studies on the malignant transformation of mouse prostate cells by carcinogenic hydrocarbons in vitro. Int J Cancer 4:166–178PubMedCrossRefGoogle Scholar
  34. 34.
    Giovanella BC, Morgan AC, Stehlin JS, Williams LJ (1973) Selective lethal effect of supranormal temperatures on mouse sarcoma cells. Cancer Res 33:2568–2578PubMedGoogle Scholar
  35. 35.
    Kase K, Hahn GM (1975) Differential heat response of normal and transformed human cells in tissue culture. Nature 255:228–230PubMedCrossRefGoogle Scholar
  36. 36.
    Maehara Y, Kusumoto T, Kusumoto H, Anai H, Akazawa K, Sugimachi K (1988) Excised human neoplastic tissues are more sensitive to heat than the adjacent normal tissues. Eur Surg Res 20:254–259PubMedCrossRefGoogle Scholar
  37. 37.
    Maehara Y, Anai H, Tamada R, Sugimachi K (1986) Partial hepatectomy alters sensitivity of rat hepatocytes to 5-fluorouracil. Cancer Lett 31:227–233PubMedCrossRefGoogle Scholar
  38. 38.
    Maehara Y, Anai H, Sugimachi K (1987) Poorly differentiated human gastric carcinoma is more sensitive to antitumor drugs than is well differentiated carcinoma. Eur J Surg Oncol 13:203–206PubMedGoogle Scholar
  39. 39.
    Sugimachi K, Inokuchi K, Kai H, Ueo H, Kuwano H, Matsufuji H (1984) Preoperative hyperthermo-chemo-radiotherapy effective for carcinoma of the esophagus. J Surg Oncol 27:199–204PubMedCrossRefGoogle Scholar
  40. 40.
    Hiraoka M, Jo S, Dodo Y, Ono K, Takahashi M, Nishida H, Abe M (1984) Clinical results of radiofrequency hyperthermia combined with radiation in the treatment of radioresistant cancers. Cancer 54: 2898–2904PubMedCrossRefGoogle Scholar
  41. 41.
    Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55–63PubMedCrossRefGoogle Scholar
  42. 42.
    Cole SPC (1986) Rapid chemosensitivity testing of human lung tumor cells using the MTT assay. Cancer Chemother Pharmacol 17:259–263PubMedCrossRefGoogle Scholar
  43. 43.
    Anai H, Maehara Y, Kusumoto H, Sugimachi K (1987) Comparison of the chemosensitivity of human neoplastic tissues between succinate dehydrogenase inhibition test and ATP assay. Clin Chim Acta 166:107–109PubMedCrossRefGoogle Scholar
  44. 44.
    Anai H, Maehara Y, Kusumoto H, Sugimachi K (1987) Comparison between succinate dehydrogenase inhibition test and subrenal capsula assay for chemosensitivity testing. Oncology 44:115–117PubMedCrossRefGoogle Scholar
  45. 45.
    Roti Roti JL (1982) Heat-induced cell death and radiosen-sitization: molecular mechanism. NC Monogr 61:3–10Google Scholar
  46. 46.
    Streffer C (1982) Aspects of biochemical effects by hyperthermia. NCI Monogr 61:11–17Google Scholar
  47. 47.
    Weber G (1977) Enzymology of cancer cells. N Engl J Med 296:486–493PubMedCrossRefGoogle Scholar
  48. 48.
    Maehara Y, Nakamura H, Nakane Y, Kawai K, Okamoto M, Nagayama S, Shirasaka T, Fujii S (1982) Activities of various enzymes of pyrimidine nucleotide and DNA syntheses in normal and neoplastic human tissue. Gann 73:289–298PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • K. Sugimachi
  • H. Matsuda

There are no affiliations available

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