Luteal-Phase Deficiency: The Most Common Abnormality of the Menstrual Cycle?
Luteal-phase deficiency (LPD) is a “modern” disease that was first described in 1949 but has only been generally accepted as real within the past 10 years (Jones 1949). The clinical entity of LPD is present when there is recurrent postovulatory deficiency in the production and/or effect of progesterone from the corpus luteum, leading to infertility and/or habitual abortion. (Synonymous terms that have been used for LPD include inadequate corpus luteum, luteal-phase inadequacy, luteal insufficiency, and luteal phase defect. The term “short luteal phase” has been used to describe a variant of LPD associated with a luteal phase of decreased length.) It should be stressed that LPD is not a single disorder; multiple causes funnel through this common pathway of decreased progesterone secretion or effect.
KeywordsDopamine Progesterone Estradiol Peri Prolactin
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