Retrovirus-Induced Tumors Whose Development is Facilitated by a Chronic Immune Response: A Comparison of Two Tumors Committed to the Monocytic Lineage

  • Linda Wolff
  • Kathryn Nason-Burchenal
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 149)


An active immune response can under certain circumstances facilitate induction of neoplasms (Schwartz and Beldotti 1965; Gleichmann et al, 1984; Potter 1986; Baumbach et al 1986; Potter et al 1987; Wolff et al 1986; Wolff et al 1988). Our studies, in particular, have shown that a chronic inflammatory granuloma in the peritoneal cavity can promote the rapid induction of myeloid tumors by retroviruses (Wolff et al 1986; Wolff et al 1988). Two myeloid tumors that arose in the peritoneal cavity of pristane-primed BALB/cAnPt mice were (a) the McML, mature monocyte-macrophage tumors induced by retroviral constructs containing exons 2 and 3 of the c-myc cDNA and (b) the MML, promonocytic tumors induced by Moloney murine leukemia virus (M-MuLV).


Moloney Murine Leukemia Virus Myeloid Tumor Active Immune Response Mature Macrophage Monocytic Lineage 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1989

Authors and Affiliations

  • Linda Wolff
    • 1
  • Kathryn Nason-Burchenal
    • 1
  1. 1.Laboratory of Genetics, National Cancer InstituteNational Institutes of HealthBethesdaUSA

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