Multistage Mastocytoma Model Characterized by Autocrine IL-3 Production
Leukaemogenesis, as tumor formation in general, is a multistage process where alterations of proto-oncogenes play some yet unknown role. To understand this process, it is necessary to know how activated proto-oncogenes (i.e., oncogenes) affect and perturb cellular growth control mechanisms from extracellular growth factors down the signal transduction pathway to the nucleus. We and others have previously reported [1, 2] that one of the frequent proto-oncogene alterations in human leukemias and lymphomas are point mutations of the ras genes (predominantly N-ras), findings which have led us to ask how an activated ras gene might affect responsiveness to hemopoietic growth factors.
KeywordsAcute Myeloid Leukemia Autocrine Loop Growth Autonomy Hybrid Culture Progression Step
Unable to display preview. Download preview PDF.