Multistage Mastocytoma Model Characterized by Autocrine IL-3 Production

  • C. Moroni
  • I. D. Diamantis
  • A. Wodnar-Filipowicz
  • A. P. K. Nair
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 32)

Abstract

Leukaemogenesis, as tumor formation in general, is a multistage process where alterations of proto-oncogenes play some yet unknown role. To understand this process, it is necessary to know how activated proto-oncogenes (i.e., oncogenes) affect and perturb cellular growth control mechanisms from extracellular growth factors down the signal transduction pathway to the nucleus. We and others have previously reported [1, 2] that one of the frequent proto-oncogene alterations in human leukemias and lymphomas are point mutations of the ras genes (predominantly N-ras), findings which have led us to ask how an activated ras gene might affect responsiveness to hemopoietic growth factors.

Keywords

Lymphoma Codon Leukemia Thymidin Nism 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • C. Moroni
    • 1
  • I. D. Diamantis
    • 1
  • A. Wodnar-Filipowicz
    • 1
  • A. P. K. Nair
    • 1
  1. 1.Institut für Medizinische MikrobiologieBaselSwitzerland

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