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HIV-I Replication Requires an Intact Integrase Reading Frame

  • H. D. Buchow
  • E. Tschachler
  • R. C. Gallo
  • M. ReitzJr.
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 32)

Abstract

Human immunodeficiency virus type I (HIV-I), is a human retrovirus that is the causative agent of acquired immune deficiency syndrome (AIDS). Retroviruses replicate through a DNA intermediate. After initial synthesis of unintegrated DNA the insertion of that DNA into the host cell genome is thought to be a required step in the retroviral life cycle [1].

Keywords

Host Cell Genome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Reference

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • H. D. Buchow
    • 1
  • E. Tschachler
    • 1
  • R. C. Gallo
    • 1
  • M. ReitzJr.
    • 1
  1. 1.National Institutes of HealthNational Cancer InstituteBethesdaUSA

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