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Isolation and Characterisation of a Myeloid Leukaemia Inducing Strain of Feline Leukaemia Virus

  • T. Tzavaras
  • N. Testa
  • J. Neil
  • D. Onions
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 32)

Abstract

Feline leukaemia virus (FeLV) is the aetiological agent of a wide range of neoplastic and degenerative conditions [1]. The predominant, naturally occurring, FeLV-induced tumours are T-cell lymphomas, and recently some of the viral events in their pathogenesis have been elucidated. Both transduction and insertional mutagenesis of the myc gene are frequent concomitants of T-cell transformation by FeLV. In addition, a possible role for the T-cell antigen receptor gene in leukaemogenesis has been revealed with the discovery of an FeLV-mediated transduction of the β-chain of the T-cell antigen receptor [2, 3].

Keywords

Myeloid Leukaemia Viral Event Proviral Integration Feline Leukaemia Virus Bone Marrow Precursor Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Neil JC, Onions DE (1985) Feline leukaemia virus: Molecular biology and pathogenesis. Anticancer Res 5: 49–64PubMedGoogle Scholar
  2. 2.
    Neil JC, Hughes D, McFarlane R, Wilkie NM, Onions DE, Lees G, Jarrett O (1984) Transduction and rearrangement of the myc gene by feline leukaemia virus in naturally occurring T-cell leukaemias. Nature 308: 814–820PubMedCrossRefGoogle Scholar
  3. 3.
    Onions D, Lees G, Forrest D, Neil JC (1987) Recombinant feline viruses containing the myc gene rapidly produce clonal tumours expressing T-cell antigen receptor gene transcripts. Int J Cancer 40: 40–45PubMedCrossRefGoogle Scholar
  4. 4.
    Moore MAS, Spitzen G, Williams N, Metcalf D, Buckley J (1974) Agar culture studies of 127 cases of untreated acute leukae-mia: the prognostic value of reclassification of leukemia according to the in vitro growth characteristics. Blood 44: 1–18PubMedGoogle Scholar
  5. 5.
    Testa NG, Dexter TM, Scott D, Teich NM (1980) Malignant myelomonocytic cells after in vitro infection of marrow cells with Friend Leukaemia Virus. Br J Cancer 41: 33–39PubMedCrossRefGoogle Scholar
  6. 6.
    Koury MJ, Pragnell IB (1982) Retroviruses induce granulocyte macrophage colony stimulating activity in fibroblasts. Nature 299: 638–640PubMedCrossRefGoogle Scholar
  7. 7.
    Testa NG, Onions D, Jarrett O, Frassoni F, Eliason JF (1983) Haemopoietic colony formation ( BFU-E GM-CFC) during the development of pure red cell hypoplasia induced in the cat by feline leukaemia virus. Leuk Res 7: 103–116PubMedCrossRefGoogle Scholar
  8. 8.
    Bordereaux D, Fichelson S, Sola B, Tambourin PE, Gisselbrecht S (1987) Frequent involvement of the fim-3 region in friend murine leukemia virus-induced mouse myeloblasts leukemias. J Virol 61: 4043–4045PubMedGoogle Scholar
  9. 9.
    Neil JC, Forrest D (1987) Mechanisms of retrovirus-induced leukaemia. Selected aspects. Biochim Biophys Acta 907: 70–79Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • T. Tzavaras
    • 1
  • N. Testa
    • 2
  • J. Neil
    • 1
  • D. Onions
    • 3
  1. 1.Beatson Institute for Cancer ResearchGlasgowUK
  2. 2.Department of Experimental HaematologyPaterson LaboratoriesManchesterUK
  3. 3.LRF Human Virus Research CentreGlasgowUK

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