Isolation and Characterisation of a Myeloid Leukaemia Inducing Strain of Feline Leukaemia Virus
Feline leukaemia virus (FeLV) is the aetiological agent of a wide range of neoplastic and degenerative conditions . The predominant, naturally occurring, FeLV-induced tumours are T-cell lymphomas, and recently some of the viral events in their pathogenesis have been elucidated. Both transduction and insertional mutagenesis of the myc gene are frequent concomitants of T-cell transformation by FeLV. In addition, a possible role for the T-cell antigen receptor gene in leukaemogenesis has been revealed with the discovery of an FeLV-mediated transduction of the β-chain of the T-cell antigen receptor [2, 3].
KeywordsMyeloid Leukaemia Viral Event Proviral Integration Feline Leukaemia Virus Bone Marrow Precursor Cell
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- 9.Neil JC, Forrest D (1987) Mechanisms of retrovirus-induced leukaemia. Selected aspects. Biochim Biophys Acta 907: 70–79Google Scholar