Isolation and Characterisation of a Myeloid Leukaemia Inducing Strain of Feline Leukaemia Virus

  • T. Tzavaras
  • N. Testa
  • J. Neil
  • D. Onions
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 32)


Feline leukaemia virus (FeLV) is the aetiological agent of a wide range of neoplastic and degenerative conditions [1]. The predominant, naturally occurring, FeLV-induced tumours are T-cell lymphomas, and recently some of the viral events in their pathogenesis have been elucidated. Both transduction and insertional mutagenesis of the myc gene are frequent concomitants of T-cell transformation by FeLV. In addition, a possible role for the T-cell antigen receptor gene in leukaemogenesis has been revealed with the discovery of an FeLV-mediated transduction of the β-chain of the T-cell antigen receptor [2, 3].


Myeloid Leukaemia Viral Event Proviral Integration Feline Leukaemia Virus Bone Marrow Precursor Cell 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • T. Tzavaras
    • 1
  • N. Testa
    • 2
  • J. Neil
    • 1
  • D. Onions
    • 3
  1. 1.Beatson Institute for Cancer ResearchGlasgowUK
  2. 2.Department of Experimental HaematologyPaterson LaboratoriesManchesterUK
  3. 3.LRF Human Virus Research CentreGlasgowUK

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