Abstract
Glucocorticoid hormones are known to have a wide variety of molecular effects by induction or repression of proteins at the transcriptional level via a receptor system. Glucocorticoids, depending on the nature of the target tissue, can not only regulate carbonhydrate, protein and nucleic acid metabolism but can also accelerate or inhibit cellular growth or differentiation. Among the cell types that involute during prolonged exposure to steroids are certain lymphocytes and lymphoma cells. This effect is the basis of steroid therapy for malignant lymphomas. The steroid-induced death of lymphoma cells has morphological characteristics clearly distinct from necrosis, i.e., early alterations of the nuclear structure together with progressive reduction of the cellular volume but preservation of the integrity of cytosolic organelles [1] which are altered early during necrosis. This second type of cell death, called apoptosis, represents an active process involving an alteration of the pattern of active genes [2] in contrast to necrosis which is the consequence of environmental perturbations.
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© 1989 Springer-Verlag Berlin Heidelberg
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Wielckens, K., Bittner, S., Delfs, T. (1989). Mechanisms of Glucocorticoid-Induced Growth Inhibition and Cell Lysis in Mouse Lymphoma Cells. In: Neth, R., et al. Modern Trends in Human Leukemia VIII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 32. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74621-5_39
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DOI: https://doi.org/10.1007/978-3-642-74621-5_39
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