Nitrate Therapy in Angina Pectoris

  • Adam Schneeweiss


Several investigators have suggested that long-term treatment with nitrates in patients with angina pectoris is associated with the development of tolerance. Although this theory is in contrast to the clinical experience of most cardiologists, it is supported by evidence from controlled trials, reported by Parker, Rudolph, Thadani and their coworkers. In this chapter the subject is reviewed, with the conclusion that tolerance to the antianginal effect can be reduced if the drugs are appropriately used. The topic is subdivided into three main areas:
  1. 1.

    Vascular tolerance

  2. 2.

    Tolerance to the antianginal effect

  3. 3.

    Cross tolerance



Angina Pectoris Guanylate Cyclase Isosorbide Dinitrate Organic Nitrate Chronic Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Adam Schneeweiss
    • 1
  1. 1.Tel AvivIsrael

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