Are There Differences Between the Various Formulations of Nitrates in Heart Failure?

  • Adam Schneeweiss


In general all nitrates exert the same hemodynamic effects in heart failure. However, there are some differences between the various molecules and routes of administration which should be known in order to optimize nitrate therapy. This discussion does not relate to obvious differences such as between transdermal nitroglycerin patches and sublingual nitroglycerin tablets but to more delicate differences. Three examples will be mentioned:
  1. 1.

    Intravenous nitroglycerin versus intravenous isosorbide dinitrate (ISDN)

  2. 2.

    Nitrate spray versus sublingual tablets

  3. 3.

    ISDN versus isosorbide mononitrate



Pulmonary Capillary Wedge Pressure Hemodynamic Effect Isosorbide Dinitrate Acute Pulmonary Edema Chronic Congestive Heart Failure 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Adam Schneeweiss
    • 1
  1. 1.Tel AvivIsrael

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