Thoughts About Gene Regulation and Mammalian Development

  • J. E. DarnellJr.
Conference paper
Part of the Bayer AG Centenary Symposium book series (BAYER)


The properties and capacities of each of the several thousand different kinds of cells in an animal body represent a composite of the properties and capacities of the proteins that each cell contains or secretes. In turn, the array of messenger RNAs in a cell and the frequency of translation of these mRNAs determine the protein content of the cell. The precursors of mRNAs are produced in the cell nucleus by RNA polymerase II, and which genes are copied by this enzyme is therefore the primary basis for determination of the nature of any particular cell. Enormous progress has been made in the past 5 years in understanding the mechanisms of this most important step in the regulation of gene expression in eukaryotic cells [9, 16, 21, 32].


Mammalian Development Stimulate Gene Activity Interact Protein Molecule Distinct Structural Motif Specific Nuclear Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • J. E. DarnellJr.
    • 1
  1. 1.Molecular Cell Biology LaboratoryRockefeller UniversityNew YorkUSA

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