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Antiandrogens: Clinical Aspects

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Abstract

For a long time, the only means for combatting hirsutism were ablative surgery, the mechanical removal of body hair such as through shaving, plucking, waxing, chemical depilation and electrolysis, or simply bleaching. When glucocorticoids became available in the early 1950s, it was hoped that adrenal hirsutism and virilism could be treated by the suppressive action of these hormonal compounds upon adrenal androgen hypersecretion via a reduction in the release of pituitary ACTH. In fact, this was shown by Wilkins et al. (1950) to be true in the case of congenital adrenal hyperplasia (originally, congenital, adrenogenital syndrome). Since that time the use of glucocorticoids has become the method of choice for this type of inborn enzymatic disturbance.

Keywords

  • Congenital Adrenal Hyperplasia
  • Cyproterone Acetate
  • Androgenetic Alopecia
  • Sebum Production
  • Hirsute Woman

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  • Abshagen U, Besenfelder R, Endele R, Koch K, Neubert B (1979) Kinetics of canrenone after single and multiple doses of spironolactone. Eur J Clin Pharmacol 16:255

    CAS  CrossRef  Google Scholar 

  • Abraham GE, Maroulis GB, Boyers SP, Buster JE, Magyar DM, Eisner CW (1981) Dexamethasone suppression test in the management of hyperandrogenized patients. Obstet Gynecol 57:158

    PubMed  CAS  Google Scholar 

  • Abrahamsson L, Hackl H, Lindstrom B (1983) Einflüsse der Antiandrogen-Behandlung mit Cyproteroneazetate (CA) auf den Sexualtonus virilisierter Frauen. Wien Klin Wochenschr 95:49

    Google Scholar 

  • Abrahamsson L, Hackl H, Lindstrom B, Sogn J (1981) Langzeitbehandlung virilisierter Frauenmit Cyproteronazetat (CA). Wien Klin Wochenschr 93:552

    Google Scholar 

  • Abramovici Y, Guillet F, Matte R, Chaieb L, Belanger R (1983) La spironolactone dans l’hirsutisme idiopathique, evaluations clinique et biologique du traitment. Ann Endocrinol (Paris) 44:393

    CAS  Google Scholar 

  • Anderson JA (1978) An assessment of (1) cyproterone acetate and (2) ethinyl oestradiol and lynoestrenol (Minilyn) in the treatment of idiopathic hirsutism. Br J Dermatol 99:545

    PubMed  CAS  CrossRef  Google Scholar 

  • Appelt H, Strauss B (1984) Effects of antiandrogen treatment on the sexuality of women with hyperandrogenism. Psychother Psychosom 42:177

    PubMed  CAS  CrossRef  Google Scholar 

  • Aram H (1987) Treatment of female androgenetic alopecia with Cimetidine. Int J Dermatol 26:128

    PubMed  CAS  CrossRef  Google Scholar 

  • Aydinlik S, Lachnit-Fixson U (1977) Diane — eine Gestagen-Östrogen-Kombination mit Antian-drogenwirkung. Med Monatsschr Pharm 31:425

    CAS  Google Scholar 

  • Aydinlik S, Lachnit-Fixson U, Lehnert J (1986) Östrogenreduzierter Ovulationshemmer zur Aknetherapie. Doppelblindstudie zum Vergleich von Diane-35 gegen Diane. Fortschr Med 104:547

    PubMed  CAS  Google Scholar 

  • Baranowska B, Stopinska-Gluszak U, Niewiadomska A, Rozbicka G (1983) Application of cyproterone acetate (Androcur) for treatment of idiopathic hirsutism and hirsutism associated with polycystic ovary syndrome. Endokrynol Pol 34:227

    Google Scholar 

  • Bardin CW, Lipsett MB (1967) Testosterone and androstenedione blood production rates in normal women and women with idiopathic hirsutism or polycystic ovaries. J Clin Invest 46:891–897

    Google Scholar 

  • Barnes EW, Irvine WJ, Hunter WM, Ismail AAA (1975) Cyproterone acetate: a study involving two volunteers with idiopathic hirsutism. Clin Endocrinol 4:65

    CAS  CrossRef  Google Scholar 

  • Baxendale PM, Jacobs HS, James VHT (1982) Salivary testosterone: relationship to unbound plasma testosterone in normal and hyperandrogenic women. Clin Endocr 16:595

    PubMed  CAS  CrossRef  Google Scholar 

  • Becker H, Düsterberg B, Klosterhalfen H (1980) Bioverfügbarkeit von Cyproteronacetat nach oraler und intramuskulärer Applikation bei Männern. Urol Int 35:381

    PubMed  CAS  CrossRef  Google Scholar 

  • Bellmann O, Bröschen-Zywietz C, Fichte K (1978) Serumkonzentrationen von Prolaktin, Wachstumshormon und Alpha-Fetoprotein bei Langzeiteinnahme eines Cyproteronehaltigen Kontrazeptivums. Geburtshilfe Frauenheilkd 38:549

    Google Scholar 

  • Bettendorf G (1968) Cassano C, Finkelstein M, Klopper A (eds) Research on steroids, vol 3. North Holland, Amsterdam, p 267

    Google Scholar 

  • Biffignandi P, Massucchetti C, Molinatti GM (1984) Female hirsutism: pathophysiological considerations and therapeutic implications. Endocr Rev 5:498

    PubMed  CAS  CrossRef  Google Scholar 

  • Boisselle A, Tremblay RR (1979) New therapeutic approach to the hirsute patient. Fertil Steril 32:276

    PubMed  CAS  Google Scholar 

  • Braendle W, Boess H, Breckwoldt M, Leven C, Bettendorf G (1974) Wirkung und Nebenwirkung der Cyproteronacetatbehandlung. Arch Gynecol 216:335

    CAS  Google Scholar 

  • Breckwoldt M, Trolp R, Braendle W, Roll H, Rachel F (1978) Anti-androgen oral contraceptives. In: Haspels AA, Kay CR (eds) International symposium on hormonal contraception. International congress series 411. Excerpta Medica, Amsterdam, p 81

    Google Scholar 

  • Burgess CA, Edwards CRW (1978) Hirsutography. Br J Photography 8:770

    Google Scholar 

  • Burton JL, Johnson C, Libman L, Shuster S (1972) Skin virilism in women with hirsutism. J Endocrinol 53:349

    PubMed  CAS  CrossRef  Google Scholar 

  • Bye P (1986) Comments on “conception during ‘Diane’ therapy — a successful outcome” (letter). Br J Dermatol 114:516

    PubMed  CAS  CrossRef  Google Scholar 

  • Caminos-Torres R, Ma L, Snyder PJ (1977) Gynecomastia and semen abnormalities induced by spironolactone in normal men. J Clin Endocrinol Metab 45:255

    PubMed  CAS  CrossRef  Google Scholar 

  • Caplan RM (1967) Gynecomastia from a non-estrogenic anti-androgen. J Clin Endocrinol 27:1348

    CAS  CrossRef  Google Scholar 

  • Carol W, Kluge K, Hempel E, Klinger G (1979) Erfahrungen mit dem Antiandrogen Cyproteronazetat bei der Behandlung des Hirsutismus. Zentralbl Gynäkol 101:497

    PubMed  CAS  Google Scholar 

  • Caron P, Denis M, Bazex J, Leuvet JP (1983) Cimetidine, new acne treatment in women? Presse Med 12:1295

    Google Scholar 

  • Carr BR (1986) The effect of Spironolactone on aromatase activity. Fertil Steril 45:655

    PubMed  CAS  Google Scholar 

  • Casey JH, Moxham A, Nabarro JDN (1964) Seasonal variation of hair-growth and response to oestrogen administration. Lancet 1:58

    Google Scholar 

  • Casey JH, Burger HG, Kent JR, Kellie AE, Moxham A, Nabarro JDN (1966) Treatment of hirsutism by adrenal and ovarian suppression. J Clin Endocrinol 26:1370

    CAS  CrossRef  Google Scholar 

  • Cermak T, Fanta D, Schneider W (1981) Behandlung des Hirsutismus mit Cyproteronacetat. Z Hautkr 56:147

    PubMed  CAS  Google Scholar 

  • Chapman MG, Jeffcoate S, Dewhurst J (1982 a) Reduced dose of oestrogen in combination with cyproterone acetate in the treatment of hirsutism. J Obstet Gynecol 3:62

    CrossRef  Google Scholar 

  • Chapman MG, Jeffcoate SL, Dewhurst CJ (1982 b) Effect of cyproterone acetate-ethinyl oestradiol treatment on adrenal function in hirsute women. Clin Endocrinol (Oxf) 17:577

    CrossRef  Google Scholar 

  • Chapman MG, Dowsett M, Dewhurst CJ, Jeffcoate SL (1985) Spironolactone in combination with an oral contraceptive: an alternative treatment for hirsutism. Br J Obstet Gynecol 92:983

    CAS  CrossRef  Google Scholar 

  • Chapman MG, Katz M, Hague W, Jeffcoate SL, Dewhurst CJ (1986) Spironolactone in the treatment of hirsutism. Acta Obstet Gynecol Scand 65:349

    PubMed  CAS  CrossRef  Google Scholar 

  • Chilvers E, Rudge P (1986) Cerebral venous thrombosis and subarachnoid haemorrhage in users of oral contraceptives. Br Med J 292:514

    CrossRef  Google Scholar 

  • Cohen J (1984) Contraception et hyperandrogenie. Point de vue du gynecologue. Contraception Fertil Sex (Suppl) 12:133

    Google Scholar 

  • Corenblum B, Rosengarten A, Taylor PJ (1986) Evaluation de femmes hirsutes par la testosterone salivaire et leur traitement par la spironolactone. Contracept Fertil Sex 14:163

    Google Scholar 

  • Cremoncini C, Vignati E, Libroia A (1976) Treatment of hirsutism and acne in women with two combinations of cyproterone acetate and ethinyl-estradiol. Acta Eur Fertil 7:299

    PubMed  CAS  Google Scholar 

  • Cullberg G, Hamberger L, Mattsson L-A, Mobacken H, Samsioe G (1985) Effects of a low-dose desogestrel-ethinylestradiol combination on hirsutism, androgens and sex hormone binding globulin in women with a polycystic ovary syndrom. Acta Obstet Gynecol Scand 64:195

    PubMed  CAS  CrossRef  Google Scholar 

  • Cumming DC, Yang JC, Rebar RW, Yen SSC (1982) Treatment of hirsutism with spironolactone. J Am Med Assoc 247:1295

    CAS  CrossRef  Google Scholar 

  • Cunliffe WJ, Shuster S, Cassels AJ (1969) The effect of topical cyproterone acetate on sebum secretion in patients with acne. Br J Dermatol 81:200

    PubMed  CAS  CrossRef  Google Scholar 

  • Cupceancu B, Hammerstein J (1969) Behandlung des Hirsutismus mit Corticoiden, Ovulationshemmern und Antiandrogenen. Geburtshilfe Frauenhkd 29:499

    Google Scholar 

  • Dalla Pria S, Greenblatt RB, Mahesh VB (1969) Antiandrogen in acne and idiopathic hirsutism. J Invest Dermatol 52:348

    PubMed  CAS  Google Scholar 

  • Daniel S (1985) Die Pharmakokinetic von Cyproteronacetat unter der hochdosierten Standardtherapie bei androgenisierten Frauen. Thesis, Freie Universität Berlin

    Google Scholar 

  • Dawber RPR, Sonnex T, Ralfs I (1982) Oral anti-androgen treatment of common baldness in women. Br J Dermatol 107 (Suppl 22):20

    Google Scholar 

  • De Oliveira RFC (1976) A new treatment for hirsutism. Ann Intern Med 83:817

    Google Scholar 

  • Dewhurst CJ, Underhill RB, Goldman S, Mansfield M (1977) The treatment of hirsutism with cyproterone acetate (an anti-androgen). Br J Obstet Gynaecol 84:119

    PubMed  CAS  CrossRef  Google Scholar 

  • Dorrington-Ward P, McCartney ACE, Holland S, Scully J, Carter G, Alaghband-Zadeh J, Wise P (1985) The effect of spironolactone on hirsutism and female androgen metabolism. Clin Endocrinol (Oxf) 23:161

    CAS  CrossRef  Google Scholar 

  • Droste-Vehn M (1990) 15β-Hydroxy-CPA und unverändertes CPA im Blut von Frauen unter umgekehrter Seynenztherapie mit CDA und EE. Thesis, Freie Universität, Berlin (in preparation)

    Google Scholar 

  • Ebling FJ, Thomas AK, Cooke ID, Randall VA, Skinner J, Dawood M (1977) Effect of cyproterone acetate on hair growth, sebaceous secretion and endocrine parameters in a hirsute subject. Br J Dermatol 97:371

    PubMed  CAS  CrossRef  Google Scholar 

  • Ebling FJG (1984) Hormones and hair: an update. J Appl Cosmetol 2:7

    CAS  Google Scholar 

  • Eil C, Edelson SK (1984) The use of human skin fibroblasts to obtain potency estimates of drug binding to androgen receptors. J Clin Endocrinol Metab 59:51

    PubMed  CAS  CrossRef  Google Scholar 

  • Evans DJ, Burke CW (1986) Spironolactone in the treatment of idiopathic hirsutism and the polycystic ovary syndrome. J R Soc Med 79:451

    PubMed  CAS  Google Scholar 

  • Evron S, Shapiro G, Diamant YZ (1981) Induction of ovulation with spironolactone (aldactone) in anovulatory oligomenorrheic and hyperandrogenie women. Fertil Steril 36:468

    PubMed  CAS  Google Scholar 

  • Falsetti L, Dordoni D, Gastaldi C, Gastaldi A (1986) A new association of ethinylestradiol (0.035 mg) cyproterone acetate (2 mg) in the therapy of polycystic ovary snydrome. Acta Eur Fertil 17:19

    PubMed  CAS  Google Scholar 

  • Ferriman D, Gallway JD (1961) Clinical assessment of body hair growth in women. J Clin Endocrinol 21:1440

    CAS  CrossRef  Google Scholar 

  • Fixson U (1963) Vorläufige Mitteilung über ein neues oral wirksames Gestagen (SH 714). Geburtshilfe Frauenhkd 23:371

    CAS  Google Scholar 

  • Floersheim Y, Keller PJ (1976) Hormonale Behandlung des Hirsutismus. Schweiz Med Wochenschr 106:573

    PubMed  CAS  Google Scholar 

  • Forbes AP (1965) Hypertrichosis. N Engl J Med 273:646

    CAS  CrossRef  Google Scholar 

  • Fräser IS, Shearman RP, Allen JK, McCarron G (1983) Cyproterone acetate and the treatment of hirsutism. Aust NZJ Obstet Gynaecol 23:93

    CrossRef  Google Scholar 

  • Frey H, Aakvaag A (1981) The treatment of essential hirsutism in women with cyproterone acetate and ethinyl estradiol. Clinical and endocrine effects in 10 cases. Acta Obstet Gynecol Scand 60:295

    PubMed  CAS  CrossRef  Google Scholar 

  • Frith RG, Phillipou G (1985) 15-Hydroxycyproterone acetate and cyproterone acetate levels in plasma and urine. J Chromatogr 338:179

    Google Scholar 

  • Frölich M, Lachinsky N, Mollenaar AJ (1977) The influence of combined cyproterone acetate-ethinyl oestradiol therapy in serum levels of dehydroepiandrosterone, androstenedione, and testosterone in hirsute women. Acta Endocrinol (Copenh) 84:333

    Google Scholar 

  • Frölich M, Vader HL, Walma ST, De Rooy HA (1980) The influence of long-term treatment with cyproterone acetate or a cyproterone acetate-ethinyl oestradiol combination on androgen levels in blood of hirsute women. J Steroid Biochem 12:499

    PubMed  CrossRef  Google Scholar 

  • Garner PR, Poznanski N (1984) Treatment of severe hirsutism resulting from hyperandrogenism with the reverse sequential cyproterone acetate regimen. J Reprod Med 29:232

    PubMed  CAS  Google Scholar 

  • Gerhards E, Gutsche H, Rieman J (1973) Biodynamik von l,2a-Methylen-6-chlor-pregna-4,6- dien-17a-acetoxy-3,20-dion (Cyproteron-acetat) nach oraler Verabreichung beim Menschen. Arzneimittelforschung 23:1550

    PubMed  CAS  Google Scholar 

  • Girard J, Baumann JB (1975) Secondary adrenal insufficiency due to cyproterone acetate. Pediatr Res 9:669

    Google Scholar 

  • Girard J, Baumann JB, Bühler U, Zuppinger K, Haas HG, Staub JJ, Wyss HI (1978) Cyproteronacetate and ACTH adrenal function. J Clin Endocrinol Metab 47:581

    PubMed  CAS  CrossRef  Google Scholar 

  • Giusti M, Parazzi F, Reitano A, Bolognese F, Giordano G (1977) Longitudinal study of the behaviour of certain hormonal parameters in women undergoing treatment with cyproterone acetate. Acta Eur Fertil 8:211

    PubMed  CAS  Google Scholar 

  • Göbel P (1968) Nebennierenrinde und Hirsutismus der Frau. Therapiewoche 18:729

    Google Scholar 

  • Goodfellow A, Alaghband-Zadeh J, Carter G, Cream JJ, Holland S, Scully J, Wise P (1984) Oral spironolactone improves acne vulgaris and reduces sebum excretion. Br J Dermatol 111:209

    PubMed  CAS  CrossRef  Google Scholar 

  • Gräf K-J, Brotherton J, Neumann F (1974) Clinical uses of antiandrogens. In: Voss HE, Oertel G (eds) Androgens and antiandrogens. Springer, Berlin Heidelberg New York, p 485 (Handbook of experimental pharmacology, vol 35/2)

    Google Scholar 

  • Gräf K-J, Schmidt-Gollwitzer M, Koch UJ, Lorenz F, Hammerstein J (1978) Hyperprolacti- naemia induced by cyproterone acetate in human subjects. Acta Endocrinol 87 (Suppl 215):96

    Google Scholar 

  • Grandesso R, Spandri R, Gangemi M, Nardelli GB, Ambrosio GB, Conte G, De Salvia D, Meneghetti G (1984) Hormonal changes and hair growth during treatment of hirsutism with Cimetidine. Clin Exp Obstet Gynecol 11:105

    PubMed  CAS  Google Scholar 

  • Greenblatt RB (1967) Progestational agents in clinical practice. Mecical Science 18:37

    Google Scholar 

  • Greenblatt RB, Gambreil RD (1985) Epilogue. In: Greenblatt RB, Mahesh VB, Gambrell RD (eds) Unwanted hairits cause and treatment. Parthenon, Carnforth, p 178

    Google Scholar 

  • Grund E, Schmidt-Eimendorff H (1975) Behandlung von Virilisierungserscheinungen. Med Welt 26:2180

    PubMed  CAS  Google Scholar 

  • Hague WM, Munro DS, Sawers RS, Duncan SLB, Honour JW (1982) Long-term effects of cyproterone acetate on the pituitary adrenal axis in adult women. Br J Obstet Gynaecol 89:981

    PubMed  CAS  CrossRef  Google Scholar 

  • Hammerstein J (1973) Antiandrogene. Arch Gynecol 214:243

    CAS  Google Scholar 

  • Hammerstein J (1980) Possible methods of endocrine therapy and Round-Table discussion. In: Hammerstein J, Lachnit-Fixson U, Neumann F, Plewig G (eds) Androgenization in women. Excerpta Medica, Amsterdam, p 221, p 278

    Google Scholar 

  • Hammerstein J, Cupceancu B (1969) Behandlung des Hirsutismus mit Cyproteronacetat. Dtsch Med Wochenschr 94:829 English Translation: The treatment of hirsutism with cyproterone acetate. German Medical Monthly 14:599

    PubMed  CAS  CrossRef  Google Scholar 

  • Hammerstein J, Meckies J, Leo-Roßberg I, Moltz L, Zielske F (1975) Use of cyproterone acetate (CPA) in the treatment of acne, hirsutism and virilism. J Steroid Biochem 6:827

    PubMed  CAS  CrossRef  Google Scholar 

  • Hammerstein J, Moltz L, Schwartz U (1983) Antiandrogens in the treatment of acne and hirsutism. J Steroid Biochem 19:591

    PubMed  CAS  CrossRef  Google Scholar 

  • Hecker A, Hasan SH, Neumann F (1978) Effect of spironolactone on the sexual differentiation of rat fetuses. Acta Endocrinol (Copenh) 87 (Suppl 215):32

    Google Scholar 

  • Hefter EL, Miller JL, Rose LI (1988) Side effects of spironolactone in the hirsute women. J Clin Endocrinol Metab 66:208

    CrossRef  Google Scholar 

  • Hertz R, Tullner WW (1958) Progestational activity of certain steroid-17 spironolactones. Proc Soc Exp Biol Med 99:451

    PubMed  CAS  Google Scholar 

  • Holdaway IM, Croxson MS, Evans MC, France J, Sheehan A, Wilson T, Ibbertson HK (1983) Effect of cyproterone acetate on glucocorticoid secretion in patients treated for hirsutism. Acta Endocrinol (Copenh) 104:222

    CAS  Google Scholar 

  • Holdaway IM, Fraser A, Sheehan A, Sheehan A., Croxson MS, France JT, Ibbertson HK (1985 a) Objective assessment of treatment response in hirsutism. Horm Res 22:253

    PubMed  CAS  CrossRef  Google Scholar 

  • Holdaway IM, Croxson MS, Ibbertson HK, Sheehan A, Knox B, France J (1985 b) Cyproterone acetate as initial treatment and maintenance therapy for hirsutism. Acta Endocrinol (Copenh) 109:522

    CAS  Google Scholar 

  • Houdent C, Kuhn JM, Balacheff O et al. (1983) Acetate de cyproterone. 15 cas d’hirsutisme traités un ans. Ann Endocrinol 44:397

    CAS  Google Scholar 

  • Hughes BR, Cunliffe WJ (1988) Tolerance of spironolactone. Brig J Dermatol 118:687

    CAS  CrossRef  Google Scholar 

  • Hümpel M, Wendt H, Schulze PE, Dogs G, Weiss C, Speck U (1977 a) Bioavailability and pharmacokinetics of cyproterone acetate after oral administration of 2.0 mg cyproterone acetate in combination with 50 [ig etinylestradiol to 6 young women. Contraception 15:579

    PubMed  CrossRef  Google Scholar 

  • Hümpel M, Wendt H, Dogs G, Weiss C, Rietz S, Speck U (1977 b) Intraindividual comparison of pharmacokinetic parameters of d-norgestrel, lynestrenol and cyproterone acetate in 6 women. Contraception 16:199

    CrossRef  Google Scholar 

  • Hümpel M, Dogs G, Wendt H, Speck U (1978) Plasmaspiegel und Pharmakokinetik von Cyproteronacetat nach oraler Applikation als 50-mg-Tablette bei 5 Männern. Arzneimittelforschung 28:319

    PubMed  Google Scholar 

  • Inaudi P, D’Ambrogio G, Massafra C, Facchini V, Genazzani AR (1982) Impaired pregnenolone secretion after combined cyproterone acetate and ethynyl estradiol therapy in hirsute patients. Gynecol Obstet Invest 14:106

    PubMed  CAS  CrossRef  Google Scholar 

  • Ismail AAA, Davidson DW, Souka AR, Barnes EW, Irvine WJ, Kilimnik H, Vanderbeeken Y (1974) The evaluation of the role of androgens in hirsutism and the use of a new antiandrogen “cyproterone acetate” for therapy. J Clin Endocrinol Metab 39:81

    PubMed  CAS  CrossRef  Google Scholar 

  • Jaffiol C, Robin M, Boyer MC, Orsetti A (1979) Etude des hormones gonadotropes, de la prolamine et de l’hirsutisme par l’acetate de cyproterone. Rev Fr Endocrinol Clin Nutr Metab 20:456

    Google Scholar 

  • Jeffcoate WJ, Edwards CRW, Rees LH, Besser GM (1976) Cyproterone acetate. Lancet 11:1140

    CrossRef  Google Scholar 

  • Jentsch D, Schulz V, Wendt H (1976) Pharmakokinetik von Cyproteronacetat bei gesunden Probanden nach intramuskulärer und oraler Applikation. Arzneimittelforschung 26:914

    PubMed  CAS  Google Scholar 

  • Jones KR, Katz M, Keyzer C, Gordon W (1981) Effect of cyproterone acetate on rate of hair growth in hirsute females. Br J Dermatol 105:685

    PubMed  CAS  CrossRef  Google Scholar 

  • Jones H, Simpson NB, Blanc D, Forster RA, Cunliffe WJ (1980) Lack of effect of Cimetidine in acne. Lancet 2:1201

    PubMed  CAS  CrossRef  Google Scholar 

  • Jost B, Meiers HG, Schmidt-Eimendorff H, Pfaffenrath V (1974) Trichometrische Quantifizierung und Verlaufsbeurteilung des Hirsutismus. Dtsch Med Wochenschr 99:2395

    PubMed  CAS  CrossRef  Google Scholar 

  • Kaiser E, Schmidt-Elmendorff H, Zimmermann H, Solbach HG (1968) Harnund Plasmasteroide unter Antiandrogen (SH 80881) — Behandlung bei Frauen mit Hirsutismus. In: Klein E (ed) Das Testosteron — Die Struma. 13. Symposium der deutschen Gesellschaft für Endokrinologie. Springer, Berlin Heidelberg New York, p 109

    Google Scholar 

  • Karim A, Zagarella J, Hutseil TC, Dooley Y (1976) Spironolactone III. Canrenone. Maximum and minimum steady-state plasma levels. Clin Pharmacol Ther 19:177

    PubMed  CAS  Google Scholar 

  • Keller FJ (1980) Round-Table discussion. In: Hammerstein J, Lachnit-Fixson U, Neumann F, Plewig G (eds) Androgenization in women. Excerpta Medica, Amsterdam, p 284

    Google Scholar 

  • Koch UJ, Lorenz F, Danehl K, Ericsson R, Hasan SH, Keyserlingk von D, Lübke K, Mehring M, Römmler A, Schwartz U, Hammerstein J (1976) Continuous oral low-dosage cyprogerone acetate for fertility regulation in the male? Contraception 14:117

    PubMed  CAS  CrossRef  Google Scholar 

  • Kolb KH, Röpke H (1968) Zur Pharmakokinetik von Cyproteronacetat. Eine vergleichende Studie bei Mensch und Pavian. Int J Clin Pharmacol 1:184

    CAS  Google Scholar 

  • Kuttenn F, Rigaud C, Wright F, Mauvais-Jarvis P (1980) Treatment of hirsutismus by oral cyproterone acetate and percutaneous estradiol. J Clin Endocrinol Metab 51:1107

    PubMed  CAS  CrossRef  Google Scholar 

  • Lachinsky N, Velde JN, Wildschut J (1976) Behandeling van hirsutisme met Cyproteronacetat. Ned Tijdschr Geneeskd 120:184

    PubMed  CAS  Google Scholar 

  • Lachnit-Fixson U (1979) The development and evaluation of an ovulation inhibitor (Diane) containing an antiandrogen. Acta Obstet Gynecol Scand [Suppl] 88:33

    CAS  CrossRef  Google Scholar 

  • Lachnit-Fixson U, Kaufmann J (1977) Zur Beeinflussung von Androgenisierungserscheinungen — Doppelblindstudie eines Cyproteronacetat-haltigen Präparates (SHB 209 AB) gegen Neogynon. Med Klin 72:1922

    PubMed  CAS  Google Scholar 

  • Larsson-Cohn U, Fahraeus L, Schenck H von, Wallentin L (1986) Effects on the lipoprotein metabolism of an antiandrogen-estrogen oral contraceptive drug. Acta Obstet Gynecol Scand 65:125

    PubMed  CAS  CrossRef  Google Scholar 

  • Lebeau M, Vokaer R (1972) Traitement de l’hirsutisme et de l’acné. Leur thérapeutique séquentielle inversée anti-androgène/oestrogène. J Gynecol Obstet Biol Reprod (Paris) 1:715

    CAS  Google Scholar 

  • Leo-Roßberg I, Laur S, Zielske F, Hammerstein J (1971) Reverse sequential therapy of hirsutism using cyproterone acetate. I. Further clinical observations. Acta Endocrinol (Copenh) 66 (Suppl) 152:14

    Google Scholar 

  • Levy J, Burshell A, Marbach M, Ayllalo L, Glick JM (1980) Interaction of spironolactone with oestradiol receptors in cytosol. J Endocrinol 84:371

    PubMed  CAS  CrossRef  Google Scholar 

  • Lobo RA, Shoupe D, Serafini P, Brinton D, Horton R (1985) The effects of two doses of spironolactone on serum androgens and anagen hair in hirsute women. Fertil Steril 43:200

    PubMed  CAS  Google Scholar 

  • Lorenzo EM (1970) Familial study of hirsutism. J Clin Endocrinol Metab 31:556

    CrossRef  Google Scholar 

  • Loriaux DL, Menard A, Taylor A, Pita JC, Santen R (1976) Spironolactone and endocrine dysfunction. Ann Intern Med 85:630

    CAS  Google Scholar 

  • Lundberg U, Hansson U, Eneroth P, Frankenhäuser M, Hagenfeldt K (1984) Anti-androgen treatment of hirsute women: a study on stress responses. J Psychosom Obstet Gynecol 3:79

    CrossRef  Google Scholar 

  • Lunell NO, Zador G, Carlstroem K, Eneroth P, Patek E, Wagner J (1982) The effect of cyproterone acetate on pituitary-ovarian function and clinical symptoms in hirsute women. Acta Endocrinol (Copenh) 100:91

    CAS  Google Scholar 

  • Lux E, Gimes R, Csomor S, Rusz E (1982) Die Persönlichkeitsund Sozialbedeutung des Hirsutismus. Zentralbl Gynäkol 104(17):1100

    PubMed  CAS  Google Scholar 

  • Lyons F, Cook J, Shuster S (1979) Inhibition of sebum excretion by an H2-blocker. Lancet 1:1376

    PubMed  CAS  CrossRef  Google Scholar 

  • Madert K-K (1980) Psychosomatische Aspekte des nichtsymptomatischen Hirsutismus. Geburtshilfe Frauenheilkd 40:648

    PubMed  CAS  CrossRef  Google Scholar 

  • Maggiolo J (1964) Medikamentöse Behandlung des Hirsutismus. Med Klin 59:1318

    PubMed  CAS  Google Scholar 

  • Mahesh VB, Zarate A, Roper BK, Greenblatt RB (1966) Studies on the action of a 17a-methyl-B-nortestosterone as an antiandrogen. Steroids 8:297

    CAS  CrossRef  Google Scholar 

  • Marsden J, Shuster S (1983) Cyclic cyproterone-ethinyloestradiol for acne (letter). Lancet 11:736

    CrossRef  Google Scholar 

  • Marsden JR, Shuster S, Lyons F (1983) Is cyclic low dose cyproterone acetate and ethinyloes-tradiol effective in acne? (letter). Lancet 11:215

    CrossRef  Google Scholar 

  • Masahashi T, Wu MC, Ohsawa M, Asai M, Ichikawa Y, Hanai K, Kikkawa H, Mizutani S (1986) Spironolactone therapy for hyperandrogenic anovulatory women. Clinical and endocrinological study. Acta Obstet Gynecol Jpn 38:95

    CAS  Google Scholar 

  • Mauvais-Jarvis P, Decourt P (1964) L’inhibition ovraienne thérapeutique par les progestatifs de synthèse. Semin Hôp Paris 40:2659

    CAS  Google Scholar 

  • Menard RH, Stripp B, Gilette JR (1974) Spironolactone and testicular cytochrome P-450: decreased testicular formation in several species and changes in hepatic drug metabolism. Endocrinology 94:1628

    PubMed  CAS  CrossRef  Google Scholar 

  • Messina M, Garione I, Molinatti GM(1970) Spironolattone ed irsutismo femminile. Osservazioni preliminari. Minerva Endocrinol 1:31

    Google Scholar 

  • Messina M, Manieri C, Rizzi G (1983 a) A new therapeutic approach to acne: an antiandrogen percutaneous treatment with spironolactone. Curr Ther Res 34:319

    Google Scholar 

  • Messina M, Manieri C, Biffigandi P, Massucchetti C, Novi RF, Molinatti GM (1983 b) Antian-drogenic properties of spironolactone. Clinical trial in the management of female hirsutism. J Endocrinol Invest 6:23

    PubMed  CAS  Google Scholar 

  • Michel B, Sultan C, Meynadier J (1983) Echec du traitement de l’hirsutisme idiopathique parla Cimetidine. Ann Dermatol Venereol 110:155

    PubMed  CAS  Google Scholar 

  • Milewicz A, Silber D, Kirschner MA (1983) Therapeutic effects of spironolactone in polycystic ovary syndrome. Obstet Gynecol 61:429

    PubMed  CAS  Google Scholar 

  • Miller JA, Jacobs HS (1986) Treatment of hirsutism and acne with cyproterone acetate. Clinics in Endocrinology and Metabolism 15:373

    PubMed  CAS  CrossRef  Google Scholar 

  • Miller JA, Wojnarowska FT, Dowd PM, Ashton RE, O’Brien TJO, Griffiths WAD, Jacobs HS (1986) Anti-androgen treatment in women with acne: a controlled trial. Br J Dermatol 114:705

    PubMed  CAS  CrossRef  Google Scholar 

  • Molinatti GM, Messina M, Manieri C, Massucchetti C, Biffignandi P (1983) Current approaches to the treatment of virilizing syndromes. In: Molinatti GM, Martini L, James VHT (eds) Androgenisation in women. Raven, New York, p 179

    Google Scholar 

  • Moltz L, Kaiser E (1984) Mittelhochdosierte orale Cyproteronacetat-Therapie bei Frauen mit mittelgradig ausgeprägten Androgenisierungserscheinungen. Ergebnisse aus einer multizentrischen Doppelblind-Studie. Geburtshilfe Frauenhkd 44:47

    CAS  CrossRef  Google Scholar 

  • Moltz L, Meckies J, Hammerstein J (1979) Die kontrazeptive Betreuung androgenisierter Frauen mit einem niedrigdosierten cyproteronacetathaltigen Einphasenpräparat. Dtsch Med Wochenschr 104:1376

    PubMed  CAS  CrossRef  Google Scholar 

  • Moltz L, Fuchs P, Bidlingmeier F, Haase F, Römmler A, Schwartz U, Hammerstein J, Oelkers W (1980) Effects of norethindrone acetate, medroxyprogesterone acetate, and cyproterone acetate on pituitary-adrenal-ovarian function in women. In: 6th International Congress of Endocrinology (Program and abstracts). Melbourne, p 630

    Google Scholar 

  • Moltz L, Schwartz U, Hammerstein J (1982) Management of cutaneous virilism with cyproterone acetate. In: Jeffcoate SL (eds) Androgens and anti-androgen therapy. Wiley, Chichester, p 113

    Google Scholar 

  • Moltz L, Haase F, Schwartz U, Hammerstein J (1983) Die Behandlung androgenisierter Frauenmit intramuskulär applizierbarem Cyproteronacetat. Geburtshilfe Frauenhkd 43:281

    CAS  CrossRef  Google Scholar 

  • Moltz L, Schwartz U, Sörensen R, Pickartz H, Hammerstein J (1984) Ovarian and adrenal vein steroids in patients with nonneoplastic hyperandrogenism: selective catherization findings. Fertil Steril 42:69

    PubMed  CAS  Google Scholar 

  • Mortimer CH, Rushton H, James KC (1984) Effective medical treatment for common baldness in women. Clin Exp Dermatol 9:342

    PubMed  CAS  CrossRef  Google Scholar 

  • Mosonyi L, Halmy L, Zöld M, Bönsze M, Feher T (1974) Erfahrungen in der Behandlung des Hirsutismus mit antiandrogenen Mitteln. Zbb Gynäkol 96:583

    CAS  Google Scholar 

  • Mowszowicz I, Wright F, Vincens M, Rigaud C, Nahoul K, Mavier P, Guillemant S, Kuttenn F, Mauvais-Jarvis P (1984) Androgen metabolism in hirsute patients treated with cyproterone acetate. J Steroid Biochem 20:757

    PubMed  CAS  CrossRef  Google Scholar 

  • Mühlendahl KE, Weber B, Müller-Hess R, Korth-Schütz S, Helge H (1977) Nebennierenrinden-insuffizienz by Cyproteronacetat-Behandlung. Dtsch Med Wochenschr 102:1074

    CrossRef  Google Scholar 

  • Nagel R, Kolb K-H, Kroemer C, Maksimovic P, Laudahn G (1973) Verteilungsstudien und pharmakokinetische Parameter nach i.m.-Gabe von Gestonoron-capronat (Depotstat) und Cyproteronacetat (Androcur) beim Menschen. Verh Dtsch Ges Urol 24:133

    Google Scholar 

  • Nardi M, De Aloysio D, De Busacchi P, Flamigni C (1975) Cyproterone acetate — ethinylestradiol treatment of hirsutism, acne, seborrhea and alopecia. Acta Eur Fertil 6:152

    Google Scholar 

  • Nelson RM, Rakoff AE (1970) Hirsutism and acne treated by an androgen antagonist. Obstet Gynecol 36:748

    PubMed  CAS  Google Scholar 

  • Nielsen DR, Larsen J, Pedersen IM, Starup J (1985) Hirsutisme behandlet med Cyproteronacetatog etinylostradiol. Ugeskr Laeger 147:2589

    PubMed  CAS  Google Scholar 

  • Nielson PG (1982) Treatment of moderate idiopathic hirsutism with a cream containing canrenone (an antiandrogen). Dermatologica 165:636

    Google Scholar 

  • Nigam S, Mantell K, Droste-Vehn M, Daniel S, Hammerstein J (1982) Determination of cyproterone acetate and its hydroxylated metabolite in plasma of hirsute patients by high performance liquid chromatography (Poster presentation). In: Sixth international congress on hormonal steroids, Jerusalem, 5–10 Sept 1982

    Google Scholar 

  • Ober KP, Hennessy JF (1978) Spironolactone therapy for hirsutism in a hyperandrogenic woman. Ann Intern Med 89:643

    PubMed  CAS  Google Scholar 

  • Pasquali R, Fabbri R, Venturoli S, Paradisi R, Antenucci D, Melchionda N (1986) Effect of weight loss and antiandrogenic therapy on sex hormone blood levels and inuslin resistance in obese patients with polycystic ovaries. Am J Obstet Gynecol 154:139

    PubMed  CAS  Google Scholar 

  • Peereboom-Wynia JD, Beek CH (1977) The influence of cyproteron-acetate orally on the hair root status in women with idiopathic hirsutism. Arch Dermatol Res 260:137

    PubMed  CAS  CrossRef  Google Scholar 

  • Peereboom-Wynia JDR, Boekhorst JC (1980) Effect of cyproterone acetate orally on hair density and diameter and endocrine factors in women with idiopathic hirsutism. Dermatologica 160:7

    PubMed  CAS  CrossRef  Google Scholar 

  • Perloff WH, Channick BJ, Suplick B, Carrington ER (1958) Clinical management of idiopathic hirsutism (adrenal virilism). JAMA 167:2041

    CAS  CrossRef  Google Scholar 

  • Pfaffenrath V, Meiers HG, Schmidt-Eimendorff H, Jost B (1975) Trichometrische Erfolgsbeurteilung der Antiandrogentherapie des Hirsutismus. Aktuel Dermatol 1:37

    Google Scholar 

  • Pittaway DE, Maxson WS, Wentz AC (1985) Spironolactone in combination drug therapy for unresponsive hirsutism. Fertil Steril 43:878

    PubMed  CAS  Google Scholar 

  • Plehwe WE, Maitland JE, Williams PF, Shearman RP, Turtle JR (1985) Familial hyperinsulinemia complicated by estreme insulin resistance during pregnancy: a probable postreceptor defect. J Clin Endocrinol Metab 61:68

    PubMed  CAS  CrossRef  Google Scholar 

  • Poran J, Guber A, Schindler D, Shachor Y (1986) Pulmonary embolism after short-term treatment of acne vulgaris with ovulation suppressor agents. Med J Aust 145:345

    PubMed  CAS  Google Scholar 

  • Rabe T, Mossier K, Kiesel L, Runnebaum B (1986) Spironolactonbzw. Cyproteron-Behandlung von Patientinnen mit Androgenisierung. Ber Gynäkol Geburtsh 122:796

    Google Scholar 

  • Raspe G (ed) (1972) Schering Symposium über Sexualdeviationen und ihre medikamentöse Behandlung. Life science monographs 2. Pergamon, Oxford

    Google Scholar 

  • Rifka SM, Pita JC, Vigersky RA, Wilson YA, Loriaux DL (1978) Interactions of digitalis and spironolactone with human sex steroid receptors. J Clin Endocrinol Metab 46:338

    PubMed  CAS  CrossRef  Google Scholar 

  • Rose LI, Underwood RH, Newmark SR, Kisch ES, Williams GH (1977) Pathophysiology of spironolactone-induced gynecomastia. Ann Intern Med 87:398

    PubMed  CAS  Google Scholar 

  • Rubens R (1984) Androgen levels during cyproterone acetate and ethinyl oestradiol treatment of hirsutism. Clin Endocrinol (Oxf) 20:313

    CAS  CrossRef  Google Scholar 

  • Rubens R, Vermeulen A (1985) Antiandrogens in the treatment of hirsutism. J Steroid Biochem 23 (Suppl) 23:33S

    CrossRef  Google Scholar 

  • Salva P, Morer F, Ordonez J, Rodriguez J (1983) Treatment of idiopathic hirsute women with two combinations of cyproterone acetate. Int J Clin Pharmacol Res 3:129

    PubMed  CAS  Google Scholar 

  • Salvador J, Barberia JJ, Marti J, Forga L, Saavedra J, Moncada E (1985) Time dependency and reversibility of the effects of exclusive cyproterone acetate therapy in pituitary adrenal function in hirsute women. Acta Endocrinol (Copenh) 110:164

    CAS  Google Scholar 

  • Scheuer A, Hagen C, Loeck M, Müller R (1980) Der Einfluß von Cyproteronacetat auf die Nebennieren- und Gonadenfunktion. Med Welt 31:1557

    PubMed  CAS  Google Scholar 

  • Schindler AE, Mangold K, Friedrich E, Keller E, Goeser R (1978) Therapy of androgenetic sympatomatology with cyproterone acetate and ethinyl estradiol. Arch Gynecol 225:103

    CAS  Google Scholar 

  • Schleusener A, Nishino Y, Albring M, Neumann F, Beier S (1980) Endocrine profile of a cyproterone acetae (CPA) metabolite and its potential clinical use. Acta Endocrinol (Copenh) 94 (Suppl 234): 106

    Google Scholar 

  • Schmidt JB, Spona J (1986) Topische Cimetidinbehandlung bei Akne. Z Hautkr 61:1065

    PubMed  CAS  Google Scholar 

  • Schmidt-Eimendorff H, Steyer M (1977) Klinische Erfahrungen mit einem niedrig dosierten Antiandrogen (Cyproteronazetat) und Äthinylöstradiol bei Frauen mit Virilisierungserscheinungen. Geburtshilfe Frauenhdk 37:297

    Google Scholar 

  • Schmidt-Eimendorff H, Kaiser E, Bauchwitz MA (1967) Der Einfluß eines Antiandrogens auf die Gonadotropinausscheidung, das Endometrium und den Vaginalsmear bei Frauen mit Hirsutismus. Ach Gynec 204:133

    Google Scholar 

  • Seed M, Godsland IF, Wynn V, Jacobs HS (1984) The effects of cyproterone acetate and ethinyloestradiol on carbohydrate metabolism. Clin Endocrinol (Oxf) 21:689

    CAS  CrossRef  Google Scholar 

  • Serafîni P, Lobo RA (1985) The effects of spironolactone on adrenal steroidogenesis in hirsute women. Fertil Steril 44:595

    PubMed  Google Scholar 

  • Serafîni PC, Catalino J, Lobo RA (1985) The effect of spirinolactone on genital skin 5a-reductase activity. J Steroid Biochem 23:191

    PubMed  CrossRef  Google Scholar 

  • Shapiro G, Evron S (1980) A novel use of spironolactone: treatment of hirsutism. J Clin Endocrinol Metab 51:429

    PubMed  CAS  CrossRef  Google Scholar 

  • Shuster S (1985) Alopecia and hirsutism: a personal view. Prescr J 25:12

    Google Scholar 

  • Silvestrini F (1977) Use of antiandrogens in female endocrinology. In: Martini L, Motta M (eds) Androgens and antiandrogens. Raven, New York, p 361

    Google Scholar 

  • Smals AGH, Kloppenborg PWC, Goverde HJM, Benraad TJ (1978) The effect of cyproterone acetate on the pituitary-adrenal axis in hirsute women. Acta Endocrinol (Copenh) 87:352

    CAS  Google Scholar 

  • Spandri P, Gangemi M, Nardelli GB, Meneghetti G, Grandesso R, De Salvia D, Ambrosio GB, Predebon O (1984) Testosterone, 17 KS, 17ßE2, FSH-LH-variations and hirsutism. Clin Exp Obstet Gynecol 11:49

    PubMed  CAS  Google Scholar 

  • Speck U, Jentsch D, Kühne G, Schulze PE, Wendt H (1976 a) Bioverfügbarkeit und Pharmakokinetik von 14 C-Cyproteronacetat nach Applikation als 50-mg-Tablette. Arzneimittelforschung 26:1717

    PubMed  CAS  Google Scholar 

  • Speck U, Wendt H, Schulze PE, Jentsch D (1976 b) Bio-availability and pharmacokinetics of cyproterone acetate-14C and ethinyloestradiol-3H after oral administration as a coated tablet (SH 209 AB). Contraception 14:151

    PubMed  CAS  CrossRef  Google Scholar 

  • Spona J, Huber J, Schmidt J (1986) Inhibierung der Ovulation mit 35 Mikrogramm Äthinyl-östradiol und 2 mg Cyproteronazetat (Diane-35). Geburtshilfe Frauenheilkd 46:435

    PubMed  CAS  CrossRef  Google Scholar 

  • Stoppeiii E, Reiner E, Hümpel M (1980) Transfer of cyproterone acetate to the milk of lactating women. Contraception 22:485

    CrossRef  Google Scholar 

  • Strauss JS, Pochi PE, Sarada IR, Wotiz HH (1969) Effect of oral and topical 17a methyl-B-nor-testosterone on sebum production and plasma testosterone. J Invest Dermatol 52:95

    PubMed  CAS  Google Scholar 

  • Strauss JS, Pochi PE (1970) Assay of anti-androgens in man by the sebaceous gland response. Br J Dermatol 82 (Suppl 6):33

    CAS  CrossRef  Google Scholar 

  • Sultan A, Terraza B, Descomps B, de Paulet AC (1980) Cimetidine competition with androgens for binding to human sex skin fibroblasts androgen receptors. J Steroid Biochem 13:839

    PubMed  CAS  CrossRef  Google Scholar 

  • Sutton TJ (1979) Dermal toxicity and penetration studies following topical application of three histamine H 2-receptor antagonists with a comparison with an H 1-receptor antagonist. Toxicol Appl Pharmacol 50:459

    PubMed  CAS  CrossRef  Google Scholar 

  • Tamm J, Voigt KD, Schönrock M, Ludwig E (1970) The effect of orally administered cyproterone on the sebum production in human subjects. Acta Endocrinol 63:50

    PubMed  CAS  Google Scholar 

  • Tejero A, Guadalix FJ, Botella, Llusia J (1977) L’action de l’acétate de cyprotérone sur la testo-stérone plasmatique de la femme atteinte d’hirsutisme. J Gynecol Obstet Biol Reprod (Paris) 6:683

    CAS  Google Scholar 

  • Thomas AK, Slobodniuk, R, Taft J, Cooper M, Montalto J, Jerums G (1985) The treatment of hirsutism: experience with cyproterone acetate and spironolactone. Australas J Dermatol 26:19

    PubMed  CAS  CrossRef  Google Scholar 

  • Tremblay RR (1986) Treatment of hirsutism with spironolactone. Clin Endocrinol Metab 15:363

    PubMed  CAS  CrossRef  Google Scholar 

  • Underhill R, Dewhurst J (1979) Further clinical experience in the treatment of hirsutism with cyproterone acetate. Br J Obstet Gynaecol 86:139

    PubMed  CAS  CrossRef  Google Scholar 

  • Valenti G, Vescovi PP, Gerra G, Rastelli G, Butturini U (1985) Activation of PRL secretion by combined treatment with cyproterone acetate and ethinylestradiol. J Endocrinol Invest 8:269

    PubMed  CAS  Google Scholar 

  • van Wayjen RGA, van den Ende A (1971) Clinical pharmacological investigation of cyproteroneacetate. Gynecol Invest 2:282

    PubMed  CrossRef  Google Scholar 

  • van Wayjen RGA, van den Ende A (1976) Het anti-androgene steroid cyproterone-acetaat. Klinische farmacologie en toepassing bij hirsutisme en acne. Ned Tijdschr Geneesk 120:189

    Google Scholar 

  • van Wayjen RGA, van den Ende A (1980) Metabolic effects of cyproterone acetate. In: Hammerstein J, Lachnit-Fixson U, Neumann F, Plewig G (eds) Androgenization in women. Excerpta Medica, Amsterdam, p 247

    Google Scholar 

  • van Wayjen RGA, van den Ende A (1981) Effect of cyproterone acetate on pituitary-adrenocortical function in man. Acta Endocrinol (Copenh) 96:112

    Google Scholar 

  • van Wayjen RGA, van den Ende A (1983) Long-term treatment of hirsutism and acne with cyproterone acetate (Abstract 32). In: Internat study group for steroid hormones, 11th meeting, Rome, November 1983.Bulletin, vol 2

    Google Scholar 

  • Venturoli S, Paradisi R, Saviogotti E, Porcu E, Fabbri R, Orsini LF, Bovicelli L, Flamigni C (1985) Ultrasound study by ovarian and uterine morphology in women with policystic ovary syndrome before, during after treatment with cyproterone acetate and ethinyloestradiol. Arch Gynecol 237:1

    PubMed  CAS  CrossRef  Google Scholar 

  • Vermorken AJM, Goos CMAA, Roelofs HMJ (1980) A method for the evaluation of the local antiandrogenic action of 5a-reductase inhibitors on human skin. Br J Dermatol 102:695

    PubMed  CAS  CrossRef  Google Scholar 

  • Vigersky RA, Mehlmann I, Glass AR, Smith CE (1980) Treatment of hirsute women with Cimetidine. N Engl J Med 303:1042

    PubMed  CAS  CrossRef  Google Scholar 

  • Walton S, Cunliffe WJ, Lookingbill P, Keczkes K (1986) Lack of effect of topical spironolactone on sebum excretion. Br J Dermatol 114:261

    PubMed  CAS  CrossRef  Google Scholar 

  • Wilkins LMR, Lewis RA, Klein R, Rosemberg E (1950) The suppression of androgen secretion by cortisone in a case of congenital adrenal hyperplasia, preliminary report. Bull Johns Hopkins Hosp 86:249

    PubMed  CAS  Google Scholar 

  • Winkler K (1968) Die Antiandrogene in der Dermatologie. Gravimetrische Fettbestimmungen während Cyproteronanwendung. Arch Klin Exp Dermatol 233:296

    PubMed  CAS  CrossRef  Google Scholar 

  • Winkler K, Schaeffer H (1973) Das Verhalten der Talgsekretion während der Behandlung der Akne mit Cyproteronacetat und Äthinylöstradiol. Arch Dermatol Forsch 247:259

    PubMed  CAS  CrossRef  Google Scholar 

  • Wynn V, Godsland IF, Seed M, Jacobs HS (1986) Paradoxical effects of the anti-androgen cyproterone acetate on lipid and lipoprotein metabolism. Clin Endocrinol (Oxf) 24:183

    CAS  CrossRef  Google Scholar 

  • Ylöstalo P, Laakso L, Viinikka L, Ylikorkalo O, Vihko R (1981) Cyproterone acetate in the treatment of hirsutism. Acta Obstet Gynecol Scand 60:399

    PubMed  CrossRef  Google Scholar 

  • Zarate A, Mahesh VB, Greenblatt RB (1966) Effect of an antiandrogen, 17a-methyl-B-nortes-tosterone, on acne and hirsutism. J Clin Endocrinol 26:1394

    CAS  CrossRef  Google Scholar 

  • Zaun H (1976) Systemische Therapie mit Sexualhormonen in der dermatologischen Praxis. Akt Dermatol 2:33

    CAS  Google Scholar 

  • Zaun H (1983) Some new aspects in the diagnosis and treatment of non-cicatricial alopecias. In: Kukita A, Seiji M (eds) Proceedings of the 16th international congress of dermatology. University of Tokio Press, Tokio, p 113

    Google Scholar 

  • Zaun H (1984) Indikation und Grenzen der antiandrogenen Therapie. Z Hautkr 59:1090

    PubMed  CAS  Google Scholar 

  • Zielske F, Leo-Roßberg I, Dreykluft R, Römmler A, Hammerstein J (1971) Treatment of hirsutism and signs of virilism with a reversed sequential administration of cyproterone acetate and ethinyl oestradiol. Clinical and endocrinological aspects. Acta Endocrinol (Copenh) [Suppl] 155:172

    Google Scholar 

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Hammerstein, J. (1990). Antiandrogens: Clinical Aspects. In: Orfanos, C.E., Happle, R. (eds) Hair and Hair Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74612-3_35

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