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Antiandrogens and Hair Growth: Basic Concepts and Experimental Research

  • Chapter
Hair and Hair Diseases

Abstract

The term antiandrogen had already appeared several times over the years up to 1963. Estrogens, for instance, were thought to have antiandrogenic properties because they could inhibit the growth of the comb in chicks and roosters — a classical parameter of androgenic action (Gley and Delor 1937 a, b; Muhlenbock 1938 a, b, c, d). Mammals, however, do not display any direct antagonism between androgens and estrogens (Neumann et al. 1968). Other substances, socalled partial agonists/antagonists, displayed antiandrogenic properties only within a certain dose range — at high doses they were androgenic. This phenomenon, i.e., that a weak hormone at an appropriate dosage can to some extent suppress the action of a strong hormone, can be explained by the mechanism of action of sex hormones working via steroid receptor binding. Naturally, such weak androgens with only limited antiandrogenic properties had not found any particular interest. These substances were in any case unsuitable for clinical application.

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  1. F. Neumann
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  2. M. Töpert
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Editors and Affiliations

  1. Department of Dermatology, University Medical Center Steglitz, The Free University of Berlin, Berlin, FR Germany

    Constantin E. Orfanos

  2. Department of Dermatology, University of Nijmegen, NL-6500 HB, Nijmegen, The Netherlands

    Rudolf Happle

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Neumann, F., Töpert, M. (1990). Antiandrogens and Hair Growth: Basic Concepts and Experimental Research. In: Orfanos, C.E., Happle, R. (eds) Hair and Hair Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74612-3_34

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