Toxicology and Carcinogenicity of 1,3-Butadiene
1,3-Butadiene (CAS No. 106-99-0) is a colorless, flammable, noncorrosive gas (boiling point: —4.4°C; vapour pressure at 20°C: 1900 mmHg) produced largely as a coproduct of ethylene production (Kirshenbaum 1978). Butadiene is a reactive material and can dimerize to 4-vinylcyclohexene. Because butadiene can form explosive peroxides in air, it is shipped with an inhibitor of peroxide formation, such as t-butylcatechol.
KeywordsLymphoma Adenoma Rubber Sarcoma Oligomer
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- Carpenter CP, Shaffer CB, Weil CS, Smyth HF Jr (1944) Studies on the inhalation of 1:3-butadiene; with a comparison of its narcotic effect with benzol, toluol, and styrene, and a note on the elimination of styrene by the human. J Ind Hyg Toxicol 26:69–78.Google Scholar
- Irons RD (1989) Studies on the mechanism of butadiene-induced leukemogenesis: the potential role of endogenous murine leukemia virus. Environ Health Perspect (in press).Google Scholar
- Kirshenbaum I (1978) Butadiene. In: Kirk-Othmer encyclopedia of chemical technology, vol 4, 3rd edn. Wiley, New York, pp 313–337.Google Scholar
- Matanoski GM, Santos-Burgoa C, Schwartz L (1989) Mortality of a cohort of workers in the styrene-butadiene polymer (SBR) manufacturing industry 1943–1982. Environ Health Perspect (in press).Google Scholar
- Melnick RL, Huff JE, Roycroft JH, Chou BJ, Miller RA (1989) Inhalation toxicology and carcinogenicity of 1,3-butadiene in B6C3F1 mice following 65 weeks exposure. Environ Health Perspect (in press).Google Scholar
- Miller LM (1978) Investigations of selected potential environmental contaminants: butadiene and its oligomers. EPA-560/2-78-008. US Environmental Protection Agency, Washington DC.Google Scholar
- Morrow NL (1989) Industrial production and use of 1,3-butadiene. Environ Health Perspect (in press).Google Scholar
- National Toxicology Program (1984) Toxicology and carcinogenesis studies of 1,3-butadiene (CAS no 106-99-0) in B6C3F1 mice (inhalation studies). NTP TR no 288, Research Triangle Park, NC.Google Scholar
- Van Duuren BL, Nelson N, Orris L, Palmes ED, Schmitt FL (1963) Carcinogenicity of epoxides, lactones, and peroxy compounds. J NCI 31:41–55.Google Scholar
- Van Duuren BL, Orris L, Nelson N (1965) Carcinogenicity of epoxides, lactones, and peroxy compounds, pt II. J NCI 35:707–717.Google Scholar
- Van Duuren BL, Langseth L, Orris L, Teebor G, Nelson N, Kuschner M (1966) Carcinogenicity of epoxides, lactones, and peroxy compounds. IV. Tumor response in epithelial and connective tissue in mice and rats. J NCI 37:825–838.Google Scholar