Cross-Reactivity Between Streptococcus and Human Tissue: A Model of Molecular Mimicry and Autoimmunity

  • J. Froude
  • A. Gibofsky
  • D. R. Buskirk
  • A. Khanna
  • J. B. Zabriskie
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 145)


Structural homology between mammalian tissues and microbes has been demonstrated for over 50 years. Twenty years ago the term “molecular mimicry” was coined to describe antigenic structures common to host and protozoal parasites (Damian 1964). This term has since been expanded to include other microorganisms, and knowledge of the phenomenon has increased greatly with the application of newer immunochemical and molecular biological techniques. Cross-reacting antibodies to the shared antigens may arise, and a partial list of these and the disease states with which they may be associated is shown in Table 1.


Hyaluronic Acid Rheumatic Fever Rheumatic Heart Disease Molecular Mimicry Streptococcal Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • J. Froude
    • 1
  • A. Gibofsky
    • 2
  • D. R. Buskirk
    • 1
  • A. Khanna
    • 1
  • J. B. Zabriskie
    • 1
  1. 1.Laboratory of Bacteriology and ImmunologyRockefeller UniversityNew YorkUSA
  2. 2.Multipurpose Arthritis Center, Hospital for Special SurgeryCornell University Medical CollegeUSA

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