Analysis of Hepatitis B Virus Gene Functions in Tissue Culture and In Vivo
The hepatitis B viruses, also called hepadnaviruses, are enveloped DNA viruses which primarily infect liver cells (reviewed by Ganem and Varmus 1987). The most important member of this virus family is the human hepatitis B virus (HBV; Dane et al. 1970), which is the causative agent of a severe form of hepatitis in humans. Since the virus is preferentially transmitted by contact with infected blood or blood products, this form of hepatitis was called serum hepatitis or hepatitis B in contrast to hepatitis A, which is caused by a Picornavirus typically transmitted by contaminated food.
KeywordsHuman Hepatoma Cell Line Minus Strand Terminal Protein Viral Core Particle Core Gene Product
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