Suppression of Cellular Gene Activity in Adenovirus-Transformed Cells
The transforming and oncogenic potential of adenoviruses is localized in the early region 1 (E1), one of the regions of the viral genome expressed in the early phase of the lytic infection. E1 is approximately 4000 base pairs long and consists of two transcriptional units, E1A and E1B. In transformed cells E1A codes for two coterminal mRNAs specifying two related proteins, whereas E1B codes for one mRNA which is translated into two unrelated proteins (for reviews, see: Bernards and Van der Eb 1984; Branton et al. 1985).
KeywordsCytoplasmic Body Major Histocompatibility Antigen Immunocompetent Animal Quantitative Immunofluorescence SV40 Large Tumor Antigen
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