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Evidence for Threshold Effects in Transformation of Pancreatic β Cells by SV40 T Antigen in Transgenic Mice

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Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY,volume 144)

Abstract

Transgenic mice harboring hybrid insulin-T antigen genes manifest heritable patterns of tumor formation (Hanahan 1985; Efrat and Hanahan 1987; Adams et al. 1987; Teitelman et al. 1988). In all mice inheriting the hybrid oncogene, denoted RIP1-Tag, its cell-specific expression in ß cells in all the pancreatic islets of Langerhans causes ß-cell transformation and proliferation, which results in islet hyperplasia. This is followed by development of only a few islets into solid, vascularized tumors and consequent premature death. It thus appears that T antigen is necessary but not sufficient for tumor formation and that additional events may be required.

Keywords

  • Hybrid Gene
  • Enhancer Element
  • Insulin Gene
  • Insulin Promoter
  • Young Adult Mouse

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© 1989 Springer-Verlag Berlin · Heidelberg

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Efrat, S., Hanahan, D. (1989). Evidence for Threshold Effects in Transformation of Pancreatic β Cells by SV40 T Antigen in Transgenic Mice. In: Knippers, R., Levine, A.J. (eds) Transforming Proteins of DNA Tumor Viruses. Current Topics in Microbiology and Immunology, vol 144. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74578-2_11

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  • DOI: https://doi.org/10.1007/978-3-642-74578-2_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74580-5

  • Online ISBN: 978-3-642-74578-2

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