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Evidence for Threshold Effects in Transformation of Pancreatic β Cells by SV40 T Antigen in Transgenic Mice

  • S. Efrat
  • D. Hanahan
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 144)

Abstract

Transgenic mice harboring hybrid insulin-T antigen genes manifest heritable patterns of tumor formation (Hanahan 1985; Efrat and Hanahan 1987; Adams et al. 1987; Teitelman et al. 1988). In all mice inheriting the hybrid oncogene, denoted RIP1-Tag, its cell-specific expression in ß cells in all the pancreatic islets of Langerhans causes ß-cell transformation and proliferation, which results in islet hyperplasia. This is followed by development of only a few islets into solid, vascularized tumors and consequent premature death. It thus appears that T antigen is necessary but not sufficient for tumor formation and that additional events may be required.

Keywords

Hybrid Gene Enhancer Element Insulin Gene Insulin Promoter Young Adult Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1989

Authors and Affiliations

  • S. Efrat
    • 1
  • D. Hanahan
    • 1
  1. 1.Cold Spring Harbor LaboratoryCold Spring HarborUSA

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