Benzodiazepine Receptor Subtypes and Their Possible Clinical Significance

  • W. Sieghart
Conference paper
Part of the Psychopharmacology Series book series (PSYCHOPHARM, volume 7)


Benzodiazepines such as diazepam, flunitrazepam or bromazepam belong to the most widely prescribed drugs in current therapeutic use because of their anxiolytic, anticonvulsant, muscle-relaxant and hypnotic effects. A large number of electrophysiological investigations indicate that benzodiazepines enhance the actions of γ-aminobutyric acid (GABA) on its receptor (Haefely et al. 1981). GABA is the quantitatively most important inhibitory neurotransmitter in the mammalian CNS. Approximately 30% of all synapses in the brain are estimated to be GABAergic. Since this GABA-enhancing effect was found in many different physiological systems, it is now generally assumed that benzodiazepines produce most of their actions by modulating the GABAergic system (Tallman et al. 1980).


Primary Central Nervous System Tumour Flunitrazepam Binding Zodiazepine Receptor Flunitrazepam Binding Site Human Primary Central Nervous System 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • W. Sieghart
    • 1
  1. 1.Department of Biochemical PsychiatryPsychiatrische UniversitätsklinikWienAustria

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