Low Selenium State and Increased Erucic Acid in Children from Keshan Endemic Areas — A Pilot Study
For over 50 years a cardiomyopathy is known to occur endemically in distinct regions of China. In the 1970s the low selenium content of soil, food and tissues was discovered and since then the prevention of Keshan disease by selenium supplementation is known. Still the pathogenesis of Keshan disease is not fully explained by selenium deficiency alone, as in other parts of the world healthy or diseased people with low selenium intake seldom suffer from cardiomyopathy. It remains questionable whether an additional environmental, infectious or nutritional factor may contribute to the pathogenesis of the disease. Mostly children of peasants who only live on locally grown food are affected. Knowing some of the nutritional habits we tried to find an additional factor which accentuates selenium deficiency and estimated in a pilot study the fatty acids in plasma of healthy children from Keshan areas.
KeywordsErucic Acid Chinese Child Selenium Content Plasma Phospholipid German Child
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- Beare-Rogers JL, Nera EA, Heggtveit HA (1971) Cardiac lipid changes in rats fed oils containing long-chain fatty acids. Can Inst Food Techn J 4: 120–124Google Scholar
- Cocchi M, Biagi PL, Maranesi M, Cipolla IM, Tavernese G, Lorusso S, Tizrchetto E (1974) Sulla presenza di acido erucico nei lipidi e nei fosfolipidi plasmatici umani. Boll Soc It Biol Sper 50: 290–294Google Scholar
- Gatti GL, Michalek H (1975) Ingestions on rape seed oil toxicology. Drug Res 25: 1639–1642Google Scholar
- Maronesi, M, Barzanti V, Cocchi M, Tavernese G, Cipolla IM, Túrchetto E (1972) Sulla presenza di acido erucico nel sangue umano. Boll Soc It Biol Sper 48: 1205–1207Google Scholar
- Trémolières A, Collomb MH, Trémolières J (1972) Effets métaboliques de l’huile de colza chez l’homme. Cah Nut Diét VII:67–71Google Scholar