Summary
Intravenous injection of P. acnes and lipopolysaccharide (LPS) into BALB/c mice resulted in acute liver failure. Treatment with ebselen (PZ-51), a seleno-organic compound, reduced serum GPT activity, and the number and size of necrotic foci of hepatocytes. These activities are suggested to be due to inhibition of leukotriene (LT) formation by ebselen.
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References
Arthur MJP, Bentley IS, Tanner AR, Kowalski Saunders P, Millward-Sadler GH, Wright R (1985) Oxygen-derived free radicals promote hepatic injury in the rat. Gastroenterology 89: 1114–1122
Mizoguchi Y, Sakagami Y, Kuboi H, Yamamoto S, MorisawaS (1987) Effect of azelastine on an experimentally-induced acute hepatic failure model. Jpn J Allergol 36: 108–111 (in Japanese)
Parnham MJ, Leyck S, Dereu N, Winkelmann J, Graf E (1986) A GSH-peroxydase-like organoselenium compound with anti-inflammatory activity. Adv Inflam Res 10: 397–400
Safayhi H, Tiegs G, Wendel A (1985) A novel biologically active seleno-organic compound — V. Inhibition by ebselen (PZ-51) of rat peritoneal neutrophil lipoxygenase. Biochem Pharmacol 34: 2691–2694
Tiegs G, Wendel A (1988) Leukotriene-mediated liver injury. Biochem Pharmacol 37: 2569–2573
Tsutsui H (1985) Studies on the experimentally induced acute hepatic failure in mice: the role of adherent cells in the induction of liver injury. Acta Hepatol Jpn 26: 1438 1444 (in Japanese)
Wendel A, Tiegs G (1986) A novel biologically active seleno-organic compound — VI. Protection by ebselen (PZ-51) against galactosamine/endotoxin-induced hepatitis in mice. Biochem Pharmacol 35: 2115–2118
Wendel A, Tiegs G (1987) Leukotriene D4 mediates galactosamine/endotoxin-induced hepatitis in mice. Biochem Pharmacol 36: 1867
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© 1989 Springer-Verlag Berlin Heidelberg
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Akasaki, M., Ikeda, T., Numata, F., Kurebayashi, Y., Tsukada, W. (1989). Effect of Ebselen (PZ-51) in Liver Failure Induced by Propionibacterium acnes (P. acnes). In: Wendel, A. (eds) Selenium in Biology and Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74421-1_32
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DOI: https://doi.org/10.1007/978-3-642-74421-1_32
Publisher Name: Springer, Berlin, Heidelberg
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