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Effect of Selenium on Adriamycin-Induced Cardiotoxicity in Mice

  • Xing Cheng
  • Guang-Lu Xu
Conference paper

Abstract

One of the most effective antitumor drugs is adriamycin (ADR) which produces a dose-related cardiomyopathy that can limit its clinical use. The ADR-induced, subacute cardiomyopathy seen in the mouse is morphologically similar to that in man (Rosenoff et al. 1975). Several studies have shown that ADR administration in mice leads to an increase in the lipid peroxide (LPO) content of the heart (Myers et al. 1977; Lentzhofer et al. 1983) and produces a decrease in cardiac glutathione perbxidase (GSH-Px) activity (Doroshow et al. 1980). ADR administration in selenium (Se)-deficient mice results in an enhanced toxicity (Doroshow et al. 1980).

Keywords

Vertical Column Plasma Vitamin Reactive Oxygen Metabolite Keshan Disease Effective Antitumor Drug 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Doroshow JH, Locker GY, Myers CE (1980) Enzymatic defenses of the mouse heart against reactive oxygen metabolite alternations produced by doxorubicin. J Clin Invest 65: 128–135PubMedCrossRefGoogle Scholar
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  4. Rosenoff SH, Olson HM, Young DM, Bostick F, Young RC (1975) Adriamycin-induced cardiac damage in the mice: a small animal model of cardiotoxicity ( Brief communication ). J Natl Cancer Inst 55: 191–194PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • Xing Cheng
    • 1
  • Guang-Lu Xu
    • 1
  1. 1.Research Laboratory of Keshan DiseaseXi’an Medical UniversityXi’an, ShaanxiThe People’s Republic of China

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