Effect of Selenium on Adriamycin-Induced Cardiotoxicity in Mice
One of the most effective antitumor drugs is adriamycin (ADR) which produces a dose-related cardiomyopathy that can limit its clinical use. The ADR-induced, subacute cardiomyopathy seen in the mouse is morphologically similar to that in man (Rosenoff et al. 1975). Several studies have shown that ADR administration in mice leads to an increase in the lipid peroxide (LPO) content of the heart (Myers et al. 1977; Lentzhofer et al. 1983) and produces a decrease in cardiac glutathione perbxidase (GSH-Px) activity (Doroshow et al. 1980). ADR administration in selenium (Se)-deficient mice results in an enhanced toxicity (Doroshow et al. 1980).
KeywordsPermeability Toxicity Peroxide Depression Glutathione
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