Effect of Selenium on Adriamycin-Induced Cardiotoxicity in Mice

  • Xing Cheng
  • Guang-Lu Xu
Conference paper


One of the most effective antitumor drugs is adriamycin (ADR) which produces a dose-related cardiomyopathy that can limit its clinical use. The ADR-induced, subacute cardiomyopathy seen in the mouse is morphologically similar to that in man (Rosenoff et al. 1975). Several studies have shown that ADR administration in mice leads to an increase in the lipid peroxide (LPO) content of the heart (Myers et al. 1977; Lentzhofer et al. 1983) and produces a decrease in cardiac glutathione perbxidase (GSH-Px) activity (Doroshow et al. 1980). ADR administration in selenium (Se)-deficient mice results in an enhanced toxicity (Doroshow et al. 1980).


Vertical Column Plasma Vitamin Reactive Oxygen Metabolite Keshan Disease Effective Antitumor Drug 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • Xing Cheng
    • 1
  • Guang-Lu Xu
    • 1
  1. 1.Research Laboratory of Keshan DiseaseXi’an Medical UniversityXi’an, ShaanxiThe People’s Republic of China

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