Selenium-Dependent Metabolic Modulations in Mouse Liver
With the discovery of glutathione peroxidase (Se-GSH-Px) as a selenoenzyme (Flohé et al. 1973) the key to the understanding of the effects of selenium (Se) deficiency was thought to be found. The loss of Se-GSH-Px is an early event during Se depletion and the resulting impairment in the detoxication of cellular hydroperoxides explains the increased susceptibility to peroxidative damage that is characteristic of Se-deficient animal models. However, recent studies from several laboratories have pointed out that Se deficiency is not simply Se-GSH-Px deficiency, and the importance of other Se proteins (Yang et al. 1987) or Se-dependent cellular pathways has been emphasized.
KeywordsDioxide Glutathione Selenium Fractionation NADPH
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- Yang J-G, Plummer JM, Burk RF (1987) J Biol Chem 262: 73Google Scholar