Selenium-Dependent Metabolic Modulations in Mouse Liver

  • R. Reiter
  • R. Otter
  • H.-M. Haney
  • A. Wendel

Abstract

With the discovery of glutathione peroxidase (Se-GSH-Px) as a selenoenzyme (Flohé et al. 1973) the key to the understanding of the effects of selenium (Se) deficiency was thought to be found. The loss of Se-GSH-Px is an early event during Se depletion and the resulting impairment in the detoxication of cellular hydroperoxides explains the increased susceptibility to peroxidative damage that is characteristic of Se-deficient animal models. However, recent studies from several laboratories have pointed out that Se deficiency is not simply Se-GSH-Px deficiency, and the importance of other Se proteins (Yang et al. 1987) or Se-dependent cellular pathways has been emphasized.

Keywords

Dioxide Glutathione Selenium Fractionation NADPH 

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • R. Reiter
    • 1
  • R. Otter
    • 1
  • H.-M. Haney
    • 1
  • A. Wendel
    • 1
  1. 1.Fakultät für BiologieUniversität KonstanzKonstanzGermany

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